Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity? a protocol for systematic review and/or meta-analysis

Introduction: Obesity is characterized as a low-grade inflammation that impairs physiological functions, including intestinal functioning and gut microbiota balance. Dietary polyphenols can be a strategy for obesity management, collaborating to preserve or recover gut health through antioxidant and...

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Principais autores: Morais, Ana Heloneida de Araujo, Dias, Lêda Karla Monteiro, Medeiros, Gidyenne Christine Bandeira Silva de, Silva, Ana Karolinne Nascimento, Maia, Juliana Kelly da Silva
Outros Autores: https://orcid.org/0000-0002-6460-911X
Formato: article
Idioma:English
Publicado em: Medicine
Assuntos:
Dysbiosis
gut health
microbiota
obesity
polyphenols
Endereço do item:https://repositorio.ufrn.br/handle/123456789/54485
http://dx.doi.org/10.1097/MD.0000000000028162
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spelling ri-123456789-544852023-08-15T22:05:08Z Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity? a protocol for systematic review and/or meta-analysis Morais, Ana Heloneida de Araujo Dias, Lêda Karla Monteiro Medeiros, Gidyenne Christine Bandeira Silva de Silva, Ana Karolinne Nascimento Maia, Juliana Kelly da Silva https://orcid.org/0000-0002-6460-911X Dysbiosis gut health microbiota obesity polyphenols Introduction: Obesity is characterized as a low-grade inflammation that impairs physiological functions, including intestinal functioning and gut microbiota balance. Dietary polyphenols can be a strategy for obesity management, collaborating to preserve or recover gut health through antioxidant and anti-inflammatory actions, as well as modulators of the microbiota. This study describes a systematic review protocol to elucidate effects of polyphenols on intestinal health of pre-clinical models with diet induced obesity. AIM: Our aim is to evaluate evidence about polyphenols’ effects in the gut microbiota composition and diversity, parameters of the physical and molecular status of the gut barrier in obese models, additionally, understand the possible involved mechanisms. Methodology: A protocol was developed and published on PROSPERO (Registration No: CRD42021262445). Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols is used to outline the protocol. The articles will be selected according to the PICOS strategy (population, interventions, control, outcome, and study design) in the following databases: PubMed, Science Direct, Scopus, Web of Science, and EMBASE. Experimental studies performed on rats and mice with a control group that describes treatment with polyphenols (from food matrix or crude extracts or isolated compounds) at any frequency, time, and dose will be included. Two reviewers will, independently, select the papers, extract data, and evaluate the data quality. The Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool will be used to assess the risk of bias. Expected results:Results will be showed through of native synthesis and, if possible, a metanalysis will be conducted. The review produced with this protocol can show the scientific evidence level about polyphenols’ effects in intestinal health in obesity status. Abbreviations: CFU = colony-forming unit, MeSH = Medical Subject Headings, OTUs = Operational taxonomic units, PICOS = population, interventions, control, outcomes, and study design, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses, PRISMA-P = Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols, PROSPERO = International Prospective Register of Systematic Reviews, SFCA = Short-chain fatty acids, SYRCLE = Systematic Review Center for Laboratory Animal Experimentation 2023-08-15T22:05:07Z 2023-08-15T22:05:07Z 2021 article DIAS, Lêda Karla Monteiro et al. Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity?: a protocol for systematic review and/or meta-analysis. Medicine, v. 100, n. 49, 2021. https://repositorio.ufrn.br/handle/123456789/54485 http://dx.doi.org/10.1097/MD.0000000000028162 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Medicine
institution Repositório Institucional
collection RI - UFRN
language English
topic Dysbiosis
gut health
microbiota
obesity
polyphenols
spellingShingle Dysbiosis
gut health
microbiota
obesity
polyphenols
Morais, Ana Heloneida de Araujo
Dias, Lêda Karla Monteiro
Medeiros, Gidyenne Christine Bandeira Silva de
Silva, Ana Karolinne Nascimento
Maia, Juliana Kelly da Silva
Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity? a protocol for systematic review and/or meta-analysis
description Introduction: Obesity is characterized as a low-grade inflammation that impairs physiological functions, including intestinal functioning and gut microbiota balance. Dietary polyphenols can be a strategy for obesity management, collaborating to preserve or recover gut health through antioxidant and anti-inflammatory actions, as well as modulators of the microbiota. This study describes a systematic review protocol to elucidate effects of polyphenols on intestinal health of pre-clinical models with diet induced obesity. AIM: Our aim is to evaluate evidence about polyphenols’ effects in the gut microbiota composition and diversity, parameters of the physical and molecular status of the gut barrier in obese models, additionally, understand the possible involved mechanisms. Methodology: A protocol was developed and published on PROSPERO (Registration No: CRD42021262445). Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols is used to outline the protocol. The articles will be selected according to the PICOS strategy (population, interventions, control, outcome, and study design) in the following databases: PubMed, Science Direct, Scopus, Web of Science, and EMBASE. Experimental studies performed on rats and mice with a control group that describes treatment with polyphenols (from food matrix or crude extracts or isolated compounds) at any frequency, time, and dose will be included. Two reviewers will, independently, select the papers, extract data, and evaluate the data quality. The Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool will be used to assess the risk of bias. Expected results:Results will be showed through of native synthesis and, if possible, a metanalysis will be conducted. The review produced with this protocol can show the scientific evidence level about polyphenols’ effects in intestinal health in obesity status. Abbreviations: CFU = colony-forming unit, MeSH = Medical Subject Headings, OTUs = Operational taxonomic units, PICOS = population, interventions, control, outcomes, and study design, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses, PRISMA-P = Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols, PROSPERO = International Prospective Register of Systematic Reviews, SFCA = Short-chain fatty acids, SYRCLE = Systematic Review Center for Laboratory Animal Experimentation
author2 https://orcid.org/0000-0002-6460-911X
author_facet https://orcid.org/0000-0002-6460-911X
Morais, Ana Heloneida de Araujo
Dias, Lêda Karla Monteiro
Medeiros, Gidyenne Christine Bandeira Silva de
Silva, Ana Karolinne Nascimento
Maia, Juliana Kelly da Silva
format article
author Morais, Ana Heloneida de Araujo
Dias, Lêda Karla Monteiro
Medeiros, Gidyenne Christine Bandeira Silva de
Silva, Ana Karolinne Nascimento
Maia, Juliana Kelly da Silva
author_sort Morais, Ana Heloneida de Araujo
title Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity? a protocol for systematic review and/or meta-analysis
title_short Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity? a protocol for systematic review and/or meta-analysis
title_full Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity? a protocol for systematic review and/or meta-analysis
title_fullStr Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity? a protocol for systematic review and/or meta-analysis
title_full_unstemmed Can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity? a protocol for systematic review and/or meta-analysis
title_sort can polyphenols improve the gut health status in pre-clinical study with diet-induced obesity? a protocol for systematic review and/or meta-analysis
publisher Medicine
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/54485
http://dx.doi.org/10.1097/MD.0000000000028162
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