Chemical inhibition of Apurinic-apyrimidinic endonuclease 1 Redox and DNA repair functions affects the inflammatory response via different but overlapping mechanisms

The presence of oxidized DNA lesions, such as 7,8-dihydro-8-oxoguanine (8-oxoG) and apurinic/apyrimidinic sites (AP sites), has been described as epigenetic signals that are involved in gene expression control. In mammals, Apurinic-apyrimidinic endonuclease 1/Redox factor-1 (APE1/Ref-1) is the main...

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Principais autores: Oliveira, Thais Teixeira, Fontes-Dantas, Fabrícia Lima, Oliveira, Rayssa Karla de Medeiros, Pinheiro, Daniele Maria Lopes, Coutinho, Leonam Gomes, Silva, Vandeclecio Lira da, Souza, Sandro José de, Agnez-Lima, Lucymara Fassarella
Formato: article
Idioma:English
Publicado em: Frontiers
Assuntos:
Apurinic/apyrimidinic endonuclease I (APE1)
DNA repair
Transcriptional control
Inflammation
ETS transcription factor
Endereço do item:https://repositorio.ufrn.br/handle/123456789/45094
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