Identification of variants (rs11571707, rs144848, and rs11571769) in the BRCA2 gene associated with hereditary breast cancer in indigenous populations of the brazilian Amazon

Estimates show that 5–10% of breast cancer cases are hereditary, caused by genetic variants in autosomal dominant genes; of these, 16% are due to germline mutations in the BRCA1 and BRCA2 genes. The comprehension of the mutation profile of these genes in the Brazilian population, particularly in...

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Principais autores: Dobbin, Elizabeth Ayres Fragoso, Medeiros, Jéssyca Amanda Gomes, Costa, Marta Solange Camarinha Ramos, Rodrigues, Juliana Carla Gomes, Guerreiro, João Farias, Kroll, José Eduardo, Souza, Sandro José de, Assumpção, Paulo Pimentel de, Ribeiro-dos-Santos, Ândrea, Santos, Sidney Emanuel Batista dos, Burbano, Rommel Mario Rodríguez, Fernandes, Marianne Rodrigues, Santos, Ney Pereira Carneiro dos
Formato: article
Idioma:English
Publicado em: MDPI AG
Assuntos:
Hereditary breast cancer
BRCA1
BRCA2
Indigenous populations
Native americans
Brazil
Endereço do item:https://repositorio.ufrn.br/handle/123456789/32797
https://doi.org/10.3390/genes12020142
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https://repositorio.ufrn.br/handle/123456789/32797
https://doi.org/10.3390/genes12020142

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