Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation

The genus Gracilaria synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed Gracilaria birdiae, have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodula...

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Principais autores: Oliveira, Leticia Castelo Branco Peroba, Queiroz, Moacir Fernandes, Fidelis, Gabriel Pereira, Melo, Karoline Rachel Teodosio, Câmara, Rafael Barros Gomes da, Alves, Monique Gabriela das Chagas Faustino, Costa, Leandro Silva, Teixeira, Dárlio Inácio Alves, Melo-Silveira, Raniere Fagundes, Rocha, Hugo Alexandre de Oliveira
Formato: article
Idioma:English
Publicado em: MDPI
Assuntos:
Sulfated galactan
Red seaweed
Antioxidant
Calcium oxalate dihydrate crystals
Urolithiasis
Endereço do item:https://repositorio.ufrn.br/handle/123456789/31189
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spelling ri-123456789-311892021-11-09T19:20:50Z Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation Oliveira, Leticia Castelo Branco Peroba Queiroz, Moacir Fernandes Fidelis, Gabriel Pereira Melo, Karoline Rachel Teodosio Câmara, Rafael Barros Gomes da Alves, Monique Gabriela das Chagas Faustino Costa, Leandro Silva Teixeira, Dárlio Inácio Alves Melo-Silveira, Raniere Fagundes Rocha, Hugo Alexandre de Oliveira Sulfated galactan Red seaweed Antioxidant Calcium oxalate dihydrate crystals Urolithiasis The genus Gracilaria synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed Gracilaria birdiae, have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodulatory effects of sulfated galactans from G. birdiae. In this study, a galactan (GB) was extracted from G. birdiae and evaluated by cell proliferation and antioxidant tests. GB showed no radical hydroxyl (OH) and superoxide (O2−) scavenging ability. However, GB was able to donate electrons in two further different assays and presented iron- and copper-chelating activity. Urolithiasis affects approximately 10% of the world’s population and is strongly associated with calcium oxalate (CaOx) crystals. No efficient compound is currently available for the treatment of this disease. GB appeared to interact with and stabilize calcium oxalate dihydrate crystals, leading to the modification of their morphology, size, and surface charge. These crystals then acquired the same characteristics as those found in healthy individuals. In addition, GB showed no cytotoxic effect against human kidney cells (HEK-293). Taken together, our current findings highlight the potential application of GB as an antiurolithic agent 2021-01-05T16:53:18Z 2021-01-05T16:53:18Z 2020-04-28 article OLIVEIRA, Leticia Castelo Branco Peroba; QUEIROZ, Moacir Fernandes; FIDELIS, Gabriel Pereira; MELO, Karoline Rachel Teodosio; CÂMARA, Rafael Barros Gomes; ALVES, Monique Gabriela Chagas Faustino; COSTA, Leandro Silva; TEIXEIRA, Dárlio Inácio Alves; MELO-SILVEIRA, Raniere Fagundes; ROCHA, Hugo Alexandre Oliveira. Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation. Molecules, [s. l.], v. 25, n. 9, p. 2055-2069, 28 abr. 2020. MDPI AG. Disponível em: https://www.mdpi.com/1420-3049/25/9/2055/htm. Acesso em: 03 ago. 2020. http://dx.doi.org/10.3390/molecules25092055. 1420-3049 (online) https://repositorio.ufrn.br/handle/123456789/31189 10.3390/molecules25092055 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf MDPI
institution Repositório Institucional
collection RI - UFRN
language English
topic Sulfated galactan
Red seaweed
Antioxidant
Calcium oxalate dihydrate crystals
Urolithiasis
spellingShingle Sulfated galactan
Red seaweed
Antioxidant
Calcium oxalate dihydrate crystals
Urolithiasis
Oliveira, Leticia Castelo Branco Peroba
Queiroz, Moacir Fernandes
Fidelis, Gabriel Pereira
Melo, Karoline Rachel Teodosio
Câmara, Rafael Barros Gomes da
Alves, Monique Gabriela das Chagas Faustino
Costa, Leandro Silva
Teixeira, Dárlio Inácio Alves
Melo-Silveira, Raniere Fagundes
Rocha, Hugo Alexandre de Oliveira
Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation
description The genus Gracilaria synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed Gracilaria birdiae, have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodulatory effects of sulfated galactans from G. birdiae. In this study, a galactan (GB) was extracted from G. birdiae and evaluated by cell proliferation and antioxidant tests. GB showed no radical hydroxyl (OH) and superoxide (O2−) scavenging ability. However, GB was able to donate electrons in two further different assays and presented iron- and copper-chelating activity. Urolithiasis affects approximately 10% of the world’s population and is strongly associated with calcium oxalate (CaOx) crystals. No efficient compound is currently available for the treatment of this disease. GB appeared to interact with and stabilize calcium oxalate dihydrate crystals, leading to the modification of their morphology, size, and surface charge. These crystals then acquired the same characteristics as those found in healthy individuals. In addition, GB showed no cytotoxic effect against human kidney cells (HEK-293). Taken together, our current findings highlight the potential application of GB as an antiurolithic agent
format article
author Oliveira, Leticia Castelo Branco Peroba
Queiroz, Moacir Fernandes
Fidelis, Gabriel Pereira
Melo, Karoline Rachel Teodosio
Câmara, Rafael Barros Gomes da
Alves, Monique Gabriela das Chagas Faustino
Costa, Leandro Silva
Teixeira, Dárlio Inácio Alves
Melo-Silveira, Raniere Fagundes
Rocha, Hugo Alexandre de Oliveira
author_facet Oliveira, Leticia Castelo Branco Peroba
Queiroz, Moacir Fernandes
Fidelis, Gabriel Pereira
Melo, Karoline Rachel Teodosio
Câmara, Rafael Barros Gomes da
Alves, Monique Gabriela das Chagas Faustino
Costa, Leandro Silva
Teixeira, Dárlio Inácio Alves
Melo-Silveira, Raniere Fagundes
Rocha, Hugo Alexandre de Oliveira
author_sort Oliveira, Leticia Castelo Branco Peroba
title Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation
title_short Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation
title_full Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation
title_fullStr Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation
title_full_unstemmed Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation
title_sort antioxidant sulfated polysaccharide from edible red seaweed gracilaria birdiae is an inhibitor of calcium oxalate crystal formation
publisher MDPI
publishDate 2021
url https://repositorio.ufrn.br/handle/123456789/31189
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