Antileishmanial effects of 4-phenyl-1-[2-(phthalimido-2-yl)ethyl]-1H-1,2,3-triazole (PT4) derivative on Leishmania amazonensis and Leishmania braziliensis: In silico ADMET, in vitro activity, docking and molecular dynamic simulations

Organic compounds obtained by the click chemistry reactions have demonstrated a broad spectrum of biological activities being widely applied for the development of molecules against pathogens of medical and veterinary importance. Cutaneous leishmaniasis (CL), caused by intracellular protozoa parasit...

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Detalhes bibliográficos
Principais autores: Holanda, Vanderlan Nogueira, Silva, Welson Vicente da, Nascimento, Pedro Henrique do, Silva, Sérgio Ruschi Bergamachi, Cabral Filho, Paulo Euzébio, Assis, Shalom Porto de Oliveira, Silva, César Augusto da, Oliveira, Ronaldo Nascimento de, Figueiredo, Regina Celia Bressan Queiroz de, Lima, Vera Lucia de Menezes
Formato: article
Idioma:English
Publicado em: Elsevier
Assuntos:
Leishmaniasis
Click chemistry
Chemotherapy
Phthalimides
Phthalimide-1,2,3-triazole
Endereço do item:https://repositorio.ufrn.br/handle/123456789/30497
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