Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo

N-methyl-D-aspartate receptor (NMDAr) antagonists such as ketamine (KET) produce psychotic-like behavior in both humans and animal models. NMDAr hypofunction affects normal oscillatory dynamics and synaptic plasticity in key brain regions related to schizophrenia, particularly in the hippocampus and...

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Principais autores: Lopes-Aguiar, Cleiton, Ruggiero, Rafael N., Rossignoli, Matheus T., Esteves, Ingrid de Miranda, Peixoto-Santos, José Eduardo, Romcy-Pereira, Rodrigo Neves, Leite, João P.
Formato: article
Idioma:English
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Assuntos:
schizophrenia
mental disorders - treatment
ketamine
long-term potentiation
neural circuits
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/28835
https://doi.org/10.1038/s41598-020-63979-5
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https://repositorio.ufrn.br/jspui/handle/123456789/28835
https://doi.org/10.1038/s41598-020-63979-5

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