Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors

Gross Chromosomal Rearrangements (GCRs) play an important role in human diseases, including cancer. Although most of the nonessential Genome Instability Suppressing (GIS) genes in Saccharomyces cerevisiae are known, the essential genes in which mutations can cause increased GCR rates are not well un...

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Principais autores:	Srivatsan, Anjana, Li, Binzhong, Sanchez, Dafne N., Somach, Steven B., Silva, Vandeclecio L. da, Souza, Sandro José de, Putnam, Christopher D., Kolodner, Richard D.
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Idioma:	English
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Assuntos:	Genome instability chromosome dynamics and replication cancer
Endereço do item:	https://repositorio.ufrn.br/jspui/handle/123456789/27645 https://doi.org/10.1073/pnas.1906921116
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spelling	ri-123456789-276452019-09-08T05:16:58Z Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors Srivatsan, Anjana Li, Binzhong Sanchez, Dafne N. Somach, Steven B. Silva, Vandeclecio L. da Souza, Sandro José de Putnam, Christopher D. Kolodner, Richard D. Genome instability chromosome dynamics and replication cancer Gross Chromosomal Rearrangements (GCRs) play an important role in human diseases, including cancer. Although most of the nonessential Genome Instability Suppressing (GIS) genes in Saccharomyces cerevisiae are known, the essential genes in which mutations can cause increased GCR rates are not well understood. Here 2 S. cerevisiae GCR assays were used to screen a targeted collection of temperature-sensitive mutants to identify mutations that caused increased GCR rates. This identified 94 essential GIS (eGIS) genes in which mutations cause increased GCR rates and 38 candidate eGIS genes that encode eGIS1 protein-interacting or family member proteins. Analysis of TCGA data using the human genes predicted to encode the proteins and protein complexes implicated by the S. cerevisiae eGIS genes revealed a significant enrichment of mutations affecting predicted human eGIS genes in 10 of the 16 cancers analyzed. 2019-09-05T16:57:11Z 2019-09-05T16:57:11Z 2019-08 article SRIVATSAN, A.; LI, B.; SANCHEZ, D. N.; SOMACH, S. B.; SILVA, V. L.; SOUZA, S. J.; PUTNAM, C. D.; KOLODNER, R. D. Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors. Proceedings of the National Academy of Sciences, [s. l.], v. 116, n. 35, p. 17377-17382, ago. 2019. DOI: https://doi.org/10.1073/pnas.1906921116. Disponível em: https://www.pnas.org/content/116/35/17377.long. Acesso em: 05 set. 2019. https://repositorio.ufrn.br/jspui/handle/123456789/27645 https://doi.org/10.1073/pnas.1906921116 en application/pdf
institution	Repositório Institucional
collection	RI - UFRN
language	English
topic	Genome instability chromosome dynamics and replication cancer
spellingShingle	Genome instability chromosome dynamics and replication cancer Srivatsan, Anjana Li, Binzhong Sanchez, Dafne N. Somach, Steven B. Silva, Vandeclecio L. da Souza, Sandro José de Putnam, Christopher D. Kolodner, Richard D. Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors
description	Gross Chromosomal Rearrangements (GCRs) play an important role in human diseases, including cancer. Although most of the nonessential Genome Instability Suppressing (GIS) genes in Saccharomyces cerevisiae are known, the essential genes in which mutations can cause increased GCR rates are not well understood. Here 2 S. cerevisiae GCR assays were used to screen a targeted collection of temperature-sensitive mutants to identify mutations that caused increased GCR rates. This identified 94 essential GIS (eGIS) genes in which mutations cause increased GCR rates and 38 candidate eGIS genes that encode eGIS1 protein-interacting or family member proteins. Analysis of TCGA data using the human genes predicted to encode the proteins and protein complexes implicated by the S. cerevisiae eGIS genes revealed a significant enrichment of mutations affecting predicted human eGIS genes in 10 of the 16 cancers analyzed.
format	article
author	Srivatsan, Anjana Li, Binzhong Sanchez, Dafne N. Somach, Steven B. Silva, Vandeclecio L. da Souza, Sandro José de Putnam, Christopher D. Kolodner, Richard D.
author_facet	Srivatsan, Anjana Li, Binzhong Sanchez, Dafne N. Somach, Steven B. Silva, Vandeclecio L. da Souza, Sandro José de Putnam, Christopher D. Kolodner, Richard D.
author_sort	Srivatsan, Anjana
title	Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors
title_short	Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors
title_full	Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors
title_fullStr	Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors
title_full_unstemmed	Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors
title_sort	essential saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors
publishDate	2019
url	https://repositorio.ufrn.br/jspui/handle/123456789/27645 https://doi.org/10.1073/pnas.1906921116
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Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors

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