In a Methotrexate-Induced Model of Intestinal Mucositis, Olmesartan Reduced Inflammation and Induced Enteropathy Characterized by Severe Diarrhea, Weight Loss, and Reduced Sucrose Activity

The aim of this study was to evaluate the effect of olmesartan (OLME), an angiotensin II receptor antagonist, on an intestinal mucositis model. Briefly, daily intraperitoneal (i.p.) injections of methotrexate (MTX) 7 mg/kg were administered to rats on 3 consecutive days. A subset of these rats was a...

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Detalhes bibliográficos
Principais autores: Araújo, Aurigena Antunes de, Borba, Pedro Brito, Souza, Fernando Henrique Destefani de, Nogueira, Anália Cristina, Saldanha, Taís Suassuna, Araújo, Thayse Emanuele Franklin, Silva, Aldemara Ingrid da, Araújo Júnior, Raimundo Fernandes de
Formato: article
Idioma:eng
Publicado em: The Pharmaceutical Society of Japan
Assuntos:
intestinal mucositis model
olmesartan
inflammation
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/25429
https://doi.org/10.1248/bpb.b14-00847
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https://repositorio.ufrn.br/jspui/handle/123456789/25429
https://doi.org/10.1248/bpb.b14-00847

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