Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis

The intestinal anti-inflammatory effect of goat milk and goat yoghurt with addition of Lactobacillus acidophilus, with or without native bee honey, was evaluated in rats with 10% acetic acid-induced colitis. The pre-treatment with goat milk, goat yoghurt or sulfasalazine significantly improved the m...

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Principais autores: Araújo, Aurigena Antunes de, Assis, Paloma Oliveira Antonino de, Guerra, Gerlane Coelho Bernardo, Araújo, Daline Fernandes de Souza, Araújo Júnior, Raimundo Fernandes de, Machado, Tamires Alcântara Dourado Gomes, Lima, Tamires Alcoforado Sena de, Garcia, Hugo Enrique Mendez, Andrade, Leylliane de Fátima Leal Interaminense de, Queiroga, Rita de Cássia Ramos do Egypto
Formato: article
Idioma:por
Publicado em: Elsevier
Assuntos:
goat milk-Intestinal anti-inflammatory activity
goat yoghurt-Intestinal anti-inflammatory
functional foods
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/25426
https://doi.org/10.1016/j.idairyj.2015.11.002
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spelling ri-123456789-254262023-02-07T19:36:18Z Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis Araújo, Aurigena Antunes de Assis, Paloma Oliveira Antonino de Guerra, Gerlane Coelho Bernardo Araújo, Daline Fernandes de Souza Araújo Júnior, Raimundo Fernandes de Machado, Tamires Alcântara Dourado Gomes Lima, Tamires Alcoforado Sena de Garcia, Hugo Enrique Mendez Andrade, Leylliane de Fátima Leal Interaminense de Queiroga, Rita de Cássia Ramos do Egypto goat milk-Intestinal anti-inflammatory activity goat yoghurt-Intestinal anti-inflammatory functional foods The intestinal anti-inflammatory effect of goat milk and goat yoghurt with addition of Lactobacillus acidophilus, with or without native bee honey, was evaluated in rats with 10% acetic acid-induced colitis. The pre-treatment with goat milk, goat yoghurt or sulfasalazine significantly improved the myeloperoxidase activity, levels of leukotriene B4 (LTB4), interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α). It also promoted a significant reduction in oxidative stress that could be seen by the reduction in malondialdehyde and the increase in glutathione. The benefit of the pre-treatments was also demonstrated in the preservation of colonic cytoarchitecture and the decreased expression of cyclooxygenase-2 and inducible nitric oxide synthase. These results suggest that goat milk and goat yoghurt exert protective effects similar to those of sulfasalazine on intestinal damage induced by acetic acid and that goat milk and goat yoghurt may act as functional foods in inflammatory bowel disease. 2018-06-16T12:23:41Z 2018-06-16T12:23:41Z 2016-05 article ARAÚJO, Aurigena Antunes de et al. Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis. International Dairy Journal, v. 56, p. 45-54, 2016. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0958694615002137?via%3Dihub>. Acesso em: 19 mar. 2018. 0958-6946 https://repositorio.ufrn.br/jspui/handle/123456789/25426 https://doi.org/10.1016/j.idairyj.2015.11.002 por Elsevier
institution Repositório Institucional
collection RI - UFRN
language por
topic goat milk-Intestinal anti-inflammatory activity
goat yoghurt-Intestinal anti-inflammatory
functional foods
spellingShingle goat milk-Intestinal anti-inflammatory activity
goat yoghurt-Intestinal anti-inflammatory
functional foods
Araújo, Aurigena Antunes de
Assis, Paloma Oliveira Antonino de
Guerra, Gerlane Coelho Bernardo
Araújo, Daline Fernandes de Souza
Araújo Júnior, Raimundo Fernandes de
Machado, Tamires Alcântara Dourado Gomes
Lima, Tamires Alcoforado Sena de
Garcia, Hugo Enrique Mendez
Andrade, Leylliane de Fátima Leal Interaminense de
Queiroga, Rita de Cássia Ramos do Egypto
Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis
description The intestinal anti-inflammatory effect of goat milk and goat yoghurt with addition of Lactobacillus acidophilus, with or without native bee honey, was evaluated in rats with 10% acetic acid-induced colitis. The pre-treatment with goat milk, goat yoghurt or sulfasalazine significantly improved the myeloperoxidase activity, levels of leukotriene B4 (LTB4), interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α). It also promoted a significant reduction in oxidative stress that could be seen by the reduction in malondialdehyde and the increase in glutathione. The benefit of the pre-treatments was also demonstrated in the preservation of colonic cytoarchitecture and the decreased expression of cyclooxygenase-2 and inducible nitric oxide synthase. These results suggest that goat milk and goat yoghurt exert protective effects similar to those of sulfasalazine on intestinal damage induced by acetic acid and that goat milk and goat yoghurt may act as functional foods in inflammatory bowel disease.
format article
author Araújo, Aurigena Antunes de
Assis, Paloma Oliveira Antonino de
Guerra, Gerlane Coelho Bernardo
Araújo, Daline Fernandes de Souza
Araújo Júnior, Raimundo Fernandes de
Machado, Tamires Alcântara Dourado Gomes
Lima, Tamires Alcoforado Sena de
Garcia, Hugo Enrique Mendez
Andrade, Leylliane de Fátima Leal Interaminense de
Queiroga, Rita de Cássia Ramos do Egypto
author_facet Araújo, Aurigena Antunes de
Assis, Paloma Oliveira Antonino de
Guerra, Gerlane Coelho Bernardo
Araújo, Daline Fernandes de Souza
Araújo Júnior, Raimundo Fernandes de
Machado, Tamires Alcântara Dourado Gomes
Lima, Tamires Alcoforado Sena de
Garcia, Hugo Enrique Mendez
Andrade, Leylliane de Fátima Leal Interaminense de
Queiroga, Rita de Cássia Ramos do Egypto
author_sort Araújo, Aurigena Antunes de
title Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis
title_short Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis
title_full Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis
title_fullStr Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis
title_full_unstemmed Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis
title_sort intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis
publisher Elsevier
publishDate 2018
url https://repositorio.ufrn.br/jspui/handle/123456789/25426
https://doi.org/10.1016/j.idairyj.2015.11.002
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