Olmesartan Decreased Levels of IL-1β and TNF-α, Down-Regulated MMP-2, MMP-9, COX-2, RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model

Methotrexate (MTX) is a pro-oxidant compound that depletes dihydrofolate pools and is widely used in the treatment of leukaemia and other malignancies. The efficacy of methotrexate is often limited by mucositis and intestinal injury, which are major causes of morbidity in children and adults. The ai...

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Principais autores: Araújo, Aurigena Antunes de, Araújo Júnior, Raimundo Fernandes de, Reinaldo, Maria Patrícia Oliveira da Silva, Brito, Gerly Anne de Castro, Cavalcanti, Pedro de França, Freire, Marco Aurélio de Moura, Medeiros, Caroline Addison Xavier de
Formato: article
Idioma:eng
Publicado em: Innsbruck Medical University, Austria
Assuntos:
Methotrexate
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/25419
https://doi.org/10.1371/journal.pone.0114923
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https://repositorio.ufrn.br/jspui/handle/123456789/25419
https://doi.org/10.1371/journal.pone.0114923

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