Histopathological prognosis of papillary thyroid carcinoma associated with nutritional status of vitamins A and E

Background/Objectives: Experimental and clinical studies have shown that vitamins A and E can inhibit cancer formation and progression. The unfavourable status of these vitamins can represent risk factors for the disease. This study aimed to evaluate the associations between the nutritional status o...

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Asıl Yazarlar: Lyra, Clélia de Oliveira, Antoine, Lara Lima, Neri, Julianna Lys de Sousa Alves, Melo, Thaisa Cristina Tavares de, Leite, Isabela Samária Fernandes, Santos, Diego Marques da Costa, Araújo, Jéssica Nayara Góes de, Silva, Ana Gabriella da Costa Lemos, Araújo, Nathália Kelly de, Ramos, Carlos César de Oliveira, Tarrapp, Sheila Ramos de Miranda Henriques, Luchessi, André Ducati, Ribeira, Karla Danielly da Silva, Silbiger, Vivian Nogueira
Materyal Türü: article
Dil:English
Baskı/Yayın Bilgisi: European Journal of Clinical Nutrition
Konular:
Papillary Thyroid Carcinoma
PTC
Vitamin A
Vitamin E
Histopathological Prognosi
Nutritional Status
Online Erişim:https://repositorio.ufrn.br/handle/123456789/57907
http://dx.doi.org/10.1038/s41430-021-00976-5
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Özet:Background/Objectives: Experimental and clinical studies have shown that vitamins A and E can inhibit cancer formation and progression. The unfavourable status of these vitamins can represent risk factors for the disease. This study aimed to evaluate the associations between the nutritional status of vitamins A and E (serum levels and dietary intake) and histopathological outcomes in Papillary Thyroid Carcinoma (PTC) patients. Subjects/Methods: We applied a cross-sectional study (2017–2018) and quantified retinol (ROH) and α-tocopherol (TOH) serum levels and vitamins dietary intake of 46 PTC patients. Serum vitamins were quantified by high efficiency liquid chromatography and vitamins dietary intake was analyzed by 24‐hr dietary recalls. Results: Patients with lower ROH serum levels were more likely to present lymph node metastasis and/or angiolymphatic invasion (p = 0.025). In addition, higher vitamin A and vitamin E intake are related to the absence of extrathyroidal extension (p = 0.013) and lymph node metastasis (p = 0.007), respectively. Our findings suggest that a ROH serum level greater than 2.65 μmol/L in PTC patients may be a protective factor against the presence of lymph node metastasis and angiolymphatic invasion. In addition, vitamin A and E intake may protect against extrathyroidal extension and lymph node metastasis. Conclusions: A favourable nutritional status (higher serum levels and/or intake) of vitamin A and E may be associated with less aggressive tumours in PTC patients

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