Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations
Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. Genome-wide association studies (GWASs) have suggested a strong association of genetic factors with the severity of the disease. However, many of these studies have been completed in European populations, and little is known a...
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ri-123456789-579052024-03-20T16:13:41Z Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations Coelho, Rita de Cássia Calderaro Martins, Carlliane Lima e Lins Pinto Pastana, Lucas Favacho Rodrigues, Juliana Carla Gomes Aguiar, Kaio Evandro Cardoso Paes, Amanda de Nazaré Cohen Gellen, Laura Patrícia Albarello Moraes, Francisco Cezar Aquino de Calderaro, Maria Clara Leite Assunção, Letícia Almeida de Silva, Natasha Monte da Pereira, Esdras Edgar Batista Santos, André Mauricio Ribeiro dos Santos, Andrea Kely Campos Ribeiro dos Burbano, Rommel Mario Rodriguez Souza, Sandro José de Guerreiro, João Farias Assumpção, Paulo Pimentel de Santos, Sidney Emanuel Batista dos Fernandes, Marianne Rodrigues Santos, Ney Pereira Carneiro dos COVID-19 SARS-CoV-2 Coronavirus Amazonian indigenous population SNP Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. Genome-wide association studies (GWASs) have suggested a strong association of genetic factors with the severity of the disease. However, many of these studies have been completed in European populations, and little is known about the genetic variability of indigenous peoples’ underlying infection by SARS-CoV-2. The objective of the study is to investigate genetic variants present in the genes AQP3, ARHGAP27, ELF5L, IFNAR2, LIMD1, OAS1 and UPK1A, selected due to their association with the severity of COVID-19, in a sample of indigenous people from the Brazilian Amazon in order to describe potential new and already studied variants. We performed the complete sequencing of the exome of 64 healthy indigenous people from the Brazilian Amazon. The allele frequency data of the population were compared with data from other continental populations. A total of 66 variants present in the seven genes studied were identified, including a variant with a high impact on the ARHGAP27 gene (rs201721078) and three new variants located in the Amazon Indigenous populations (INDG) present in the AQP3, IFNAR2 and LIMD1 genes, with low, moderate and modifier impact, respectively 2024-03-20T16:13:41Z 2024-03-20T16:13:41Z 2024-02 article COELHO, Rita de Cássia Calderaro; MARTINS, Carlliane Lima e Lins Pinto; PASTANA, Lucas Favacho; RODRIGUES, Juliana Carla Gomes; AGUIAR, Kaio Evandro Cardoso; COHEN-PAES, Amanda de Nazaré; GELLEN, Laura Patrícia Albarello; MORAES, Francisco Cezar Aquino de; CALDERARO, Maria Clara Leite; ASSUNÇÃO, Letícia Almeida de; MONTE, Natasha; PEREIRA, Esdras Edgar Batista; RIBEIRO-DOS-SANTOS, André Maurício; RIBEIRO-DO-SANTOS, BURBANO, Ândrea; RODRIGUEZ, Rommel Mario; SOUZA, Sandro José de; GUERREIRO, João Farias; ASSUMPÇÃO, Paulo Pimentel de; SANTOS, Sidney Emanuel Batista dos; FERNANDES, Marianne Rodrigues; SANTOS, Ney Pereira Carneiro dos. Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations. Viruses, [S. l.], v. 16, n. 3, p. 359, fev. 2024. Doi: http://dx.doi.org/10.3390/v16030359. Disponível em: https://www.mdpi.com/1999-4915/16/3/359. Acesso em: 20 mar. 2024 https://repositorio.ufrn.br/handle/123456789/57905 10.3390/v16030359 en application/pdf MDPI AG |
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RI - UFRN |
| language |
English |
| topic |
COVID-19 SARS-CoV-2 Coronavirus Amazonian indigenous population SNP |
| spellingShingle |
COVID-19 SARS-CoV-2 Coronavirus Amazonian indigenous population SNP Coelho, Rita de Cássia Calderaro Martins, Carlliane Lima e Lins Pinto Pastana, Lucas Favacho Rodrigues, Juliana Carla Gomes Aguiar, Kaio Evandro Cardoso Paes, Amanda de Nazaré Cohen Gellen, Laura Patrícia Albarello Moraes, Francisco Cezar Aquino de Calderaro, Maria Clara Leite Assunção, Letícia Almeida de Silva, Natasha Monte da Pereira, Esdras Edgar Batista Santos, André Mauricio Ribeiro dos Santos, Andrea Kely Campos Ribeiro dos Burbano, Rommel Mario Rodriguez Souza, Sandro José de Guerreiro, João Farias Assumpção, Paulo Pimentel de Santos, Sidney Emanuel Batista dos Fernandes, Marianne Rodrigues Santos, Ney Pereira Carneiro dos Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations |
| description |
Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. Genome-wide association studies (GWASs) have suggested a strong association of genetic factors with the severity of the disease. However, many of these studies have been completed in European populations, and little is known about the genetic variability of indigenous peoples’ underlying infection by SARS-CoV-2. The objective of the study is to investigate genetic variants present in the genes AQP3, ARHGAP27, ELF5L, IFNAR2, LIMD1, OAS1 and UPK1A, selected due to their association with the severity of COVID-19, in a sample of indigenous people from the Brazilian Amazon in order to describe potential new and already studied variants. We performed the complete sequencing of the exome of 64 healthy indigenous people from the Brazilian Amazon. The allele frequency data of the population were compared with data from other continental populations. A total of 66 variants present in the seven genes studied were identified, including a variant with a high impact on the ARHGAP27 gene (rs201721078) and three new variants located in the Amazon Indigenous populations (INDG) present in the AQP3, IFNAR2 and LIMD1 genes, with low, moderate and modifier impact, respectively |
| format |
article |
| author |
Coelho, Rita de Cássia Calderaro Martins, Carlliane Lima e Lins Pinto Pastana, Lucas Favacho Rodrigues, Juliana Carla Gomes Aguiar, Kaio Evandro Cardoso Paes, Amanda de Nazaré Cohen Gellen, Laura Patrícia Albarello Moraes, Francisco Cezar Aquino de Calderaro, Maria Clara Leite Assunção, Letícia Almeida de Silva, Natasha Monte da Pereira, Esdras Edgar Batista Santos, André Mauricio Ribeiro dos Santos, Andrea Kely Campos Ribeiro dos Burbano, Rommel Mario Rodriguez Souza, Sandro José de Guerreiro, João Farias Assumpção, Paulo Pimentel de Santos, Sidney Emanuel Batista dos Fernandes, Marianne Rodrigues Santos, Ney Pereira Carneiro dos |
| author_facet |
Coelho, Rita de Cássia Calderaro Martins, Carlliane Lima e Lins Pinto Pastana, Lucas Favacho Rodrigues, Juliana Carla Gomes Aguiar, Kaio Evandro Cardoso Paes, Amanda de Nazaré Cohen Gellen, Laura Patrícia Albarello Moraes, Francisco Cezar Aquino de Calderaro, Maria Clara Leite Assunção, Letícia Almeida de Silva, Natasha Monte da Pereira, Esdras Edgar Batista Santos, André Mauricio Ribeiro dos Santos, Andrea Kely Campos Ribeiro dos Burbano, Rommel Mario Rodriguez Souza, Sandro José de Guerreiro, João Farias Assumpção, Paulo Pimentel de Santos, Sidney Emanuel Batista dos Fernandes, Marianne Rodrigues Santos, Ney Pereira Carneiro dos |
| author_sort |
Coelho, Rita de Cássia Calderaro |
| title |
Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations |
| title_short |
Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations |
| title_full |
Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations |
| title_fullStr |
Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations |
| title_full_unstemmed |
Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations |
| title_sort |
molecular profile of variants potentially associated with severe forms of covid-19 in amazonian indigenous populations |
| publisher |
MDPI AG |
| publishDate |
2024 |
| url |
https://repositorio.ufrn.br/handle/123456789/57905 |
| work_keys_str_mv |
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