Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations

Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. Genome-wide association studies (GWASs) have suggested a strong association of genetic factors with the severity of the disease. However, many of these studies have been completed in European populations, and little is known a...

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Principais autores: Coelho, Rita de Cássia Calderaro, Martins, Carlliane Lima e Lins Pinto, Pastana, Lucas Favacho, Rodrigues, Juliana Carla Gomes, Aguiar, Kaio Evandro Cardoso, Paes, Amanda de Nazaré Cohen, Gellen, Laura Patrícia Albarello, Moraes, Francisco Cezar Aquino de, Calderaro, Maria Clara Leite, Assunção, Letícia Almeida de, Silva, Natasha Monte da, Pereira, Esdras Edgar Batista, Santos, André Mauricio Ribeiro dos, Santos, Andrea Kely Campos Ribeiro dos, Burbano, Rommel Mario Rodriguez, Souza, Sandro José de, Guerreiro, João Farias, Assumpção, Paulo Pimentel de, Santos, Sidney Emanuel Batista dos, Fernandes, Marianne Rodrigues, Santos, Ney Pereira Carneiro dos
Formato: article
Idioma:English
Publicado em: MDPI AG
Assuntos:
COVID-19
SARS-CoV-2
Coronavirus
Amazonian indigenous population
SNP
Endereço do item:https://repositorio.ufrn.br/handle/123456789/57905
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Resumo:Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. Genome-wide association studies (GWASs) have suggested a strong association of genetic factors with the severity of the disease. However, many of these studies have been completed in European populations, and little is known about the genetic variability of indigenous peoples’ underlying infection by SARS-CoV-2. The objective of the study is to investigate genetic variants present in the genes AQP3, ARHGAP27, ELF5L, IFNAR2, LIMD1, OAS1 and UPK1A, selected due to their association with the severity of COVID-19, in a sample of indigenous people from the Brazilian Amazon in order to describe potential new and already studied variants. We performed the complete sequencing of the exome of 64 healthy indigenous people from the Brazilian Amazon. The allele frequency data of the population were compared with data from other continental populations. A total of 66 variants present in the seven genes studied were identified, including a variant with a high impact on the ARHGAP27 gene (rs201721078) and three new variants located in the Amazon Indigenous populations (INDG) present in the AQP3, IFNAR2 and LIMD1 genes, with low, moderate and modifier impact, respectively

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