Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats

Objective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats. Methods: Three groups of obese rats were fed 10 days one of the following diets: Standa...

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Principais autores: Maciel, Bruna Leal Lima, Costa, Izael De Souza, Medeiros, Amanda Fernandes de, Carvalho, Fabiana Maria Coimbra de, Lima, Vanessa Cristina Oliveira de, Serquiz, Raphael Paschoal, Serquiz, Alexandre Coelho, Silbiger, Vivian Nogueira, Bortolin, Raul Hernandes, Santos, Elizeu Antunes dos
Formato: article
Idioma:English
Publicado em: Obesity Facts
Assuntos:
Cholecystokinin
Tamarindus indica L.
CCK-2R gene
PCSK1 gene
Pre-Pro-CCK gene
Ob gene
Endereço do item:https://repositorio.ufrn.br/handle/123456789/57482
http://dx.doi.org/10.1159/000492733
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spelling ri-123456789-574822024-02-02T12:44:15Z Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats Maciel, Bruna Leal Lima Costa, Izael De Souza Medeiros, Amanda Fernandes de Carvalho, Fabiana Maria Coimbra de Lima, Vanessa Cristina Oliveira de Serquiz, Raphael Paschoal Serquiz, Alexandre Coelho Silbiger, Vivian Nogueira Bortolin, Raul Hernandes Santos, Elizeu Antunes dos Cholecystokinin Tamarindus indica L. CCK-2R gene PCSK1 gene Pre-Pro-CCK gene Ob gene Objective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats. Methods: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Lean animals were fed the standard diet for the 10 days. Food intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of intestinal CCK-related genes, and expression of the ob gene in subcutaneous adipose tissue were assessed. Results: TTI decreased food intake but did not increase plasma CCK in obese animals. On the other hand, TTI treatment decreased CCK-1R gene expression in obese animals compared with the obese group with no treatment (p = 0.027). Obese animals treated with TTI presented lower plasma leptin than the non-treated obese animals. Conclusion: We suggest that TTI by decreasing plasma leptin may improve CCK action, regardless of its increase in plasma from obese rats, since food intake was lowest 2024-02-02T12:44:14Z 2024-02-02T12:44:14Z 2018 article COSTA, Izael De Souza; MEDEIROS, Amanda Fernandes de; CARVALHO, Fabiana Maria Coimbra de; LIMA, Vanessa Cristina Oliveira de; SERQUIZ, Raphael Paschoal; SERQUIZ, Alexandre Coelho; SILBIGER, Vivian Nogueira; BORTOLIN, Raul Hernandes; MACIEL, Bruna Leal Lima; SANTOS, Elizeu Antunes dos. Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats. Obesity Facts, [S.l.], v. 11, n. 6, p. 440-453, 2018. DOI: 10.1159/000492733. Disponível em: https://karger.com/ofa/article/11/6/440/239548/Satietogenic-Protein-from-Tamarind-Seeds-Decreases. Acesso em: 31 jan. 2024. https://repositorio.ufrn.br/handle/123456789/57482 http://dx.doi.org/10.1159/000492733 en Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Obesity Facts
institution Repositório Institucional
collection RI - UFRN
language English
topic Cholecystokinin
Tamarindus indica L.
CCK-2R gene
PCSK1 gene
Pre-Pro-CCK gene
Ob gene
spellingShingle Cholecystokinin
Tamarindus indica L.
CCK-2R gene
PCSK1 gene
Pre-Pro-CCK gene
Ob gene
Maciel, Bruna Leal Lima
Costa, Izael De Souza
Medeiros, Amanda Fernandes de
Carvalho, Fabiana Maria Coimbra de
Lima, Vanessa Cristina Oliveira de
Serquiz, Raphael Paschoal
Serquiz, Alexandre Coelho
Silbiger, Vivian Nogueira
Bortolin, Raul Hernandes
Santos, Elizeu Antunes dos
Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats
description Objective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats. Methods: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Lean animals were fed the standard diet for the 10 days. Food intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of intestinal CCK-related genes, and expression of the ob gene in subcutaneous adipose tissue were assessed. Results: TTI decreased food intake but did not increase plasma CCK in obese animals. On the other hand, TTI treatment decreased CCK-1R gene expression in obese animals compared with the obese group with no treatment (p = 0.027). Obese animals treated with TTI presented lower plasma leptin than the non-treated obese animals. Conclusion: We suggest that TTI by decreasing plasma leptin may improve CCK action, regardless of its increase in plasma from obese rats, since food intake was lowest
format article
author Maciel, Bruna Leal Lima
Costa, Izael De Souza
Medeiros, Amanda Fernandes de
Carvalho, Fabiana Maria Coimbra de
Lima, Vanessa Cristina Oliveira de
Serquiz, Raphael Paschoal
Serquiz, Alexandre Coelho
Silbiger, Vivian Nogueira
Bortolin, Raul Hernandes
Santos, Elizeu Antunes dos
author_facet Maciel, Bruna Leal Lima
Costa, Izael De Souza
Medeiros, Amanda Fernandes de
Carvalho, Fabiana Maria Coimbra de
Lima, Vanessa Cristina Oliveira de
Serquiz, Raphael Paschoal
Serquiz, Alexandre Coelho
Silbiger, Vivian Nogueira
Bortolin, Raul Hernandes
Santos, Elizeu Antunes dos
author_sort Maciel, Bruna Leal Lima
title Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats
title_short Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats
title_full Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats
title_fullStr Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats
title_full_unstemmed Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats
title_sort satietogenic protein from tamarind seeds decreases food intake, leptin plasma and cck-1r gene expression in obese wistar rats
publisher Obesity Facts
publishDate 2024
url https://repositorio.ufrn.br/handle/123456789/57482
http://dx.doi.org/10.1159/000492733
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