Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios
Although the semi-invariant natural killer T cells (iNKT) are a small subpopulation of cells in the peripheral blood, they are presumed to play a role in early stages of infection against various pathogens, including protozoa. This work investigates the activation status and cytokine profile of iNKT...
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ri-123456789-574722024-02-01T17:13:09Z Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios Maciel, Bruna Leal Lima Macêdo, Bruna de Góis Peixoto, Rephany Fonseca Gomes, Julliana de Assis Silva Azevedo, Fátima de Lourdes Assunção Araújo de Veras, Robson Cavalcanti Medeiros, Isac Almeida de Grisi, Teresa Cristina Soares de Lima Araújo, Demétrius Antônio Machado de Amaral, Ian Porto Gurgel do Lima, Tatjana Keesen de Souza Dual immune iNKT cells T cells Visceral leishmaniasis Although the semi-invariant natural killer T cells (iNKT) are a small subpopulation of cells in the peripheral blood, they are presumed to play a role in early stages of infection against various pathogens, including protozoa. This work investigates the activation status and cytokine profile of iNKT cells during human Leishmania infantum and Leishmania braziliensis infection. We studied iNKT cells in patients with symptomatic active visceral leishmaniasis (AVL) (n = 8), patients with symptomatic active cutaneous leishmaniasis (ACL) (n = 13), negative endemic controls (NEC) (n = 6) and non-endemic controls (NonEC) (n = 6), with and without total Leishmania antigen stimulus (TLA). The number of iNKT cells in the peripheral blood of patients with ACL and AVL unaltered in relation to control groups. Moreover, the iNKT cells from ACL showed a hyperactivation profile compared to patients with AVL. Additionally, TLA induced IFN-gamma production in iNKT cells from patients with ACL, while in iNKT of patients with AVL, TLA induced a decrease in this cytokine. Higher IL-17 and IL-10 production by iNKT cells from patients with ACL were also observed compared to all other groups. There were no changes in iNKT IL-10-producing cells in AVL after TLA stimulation. However, TLA induced increase in IL-10 in iNKT cells in patients with ACL. These findings suggest that, although iNKT cells showed distinct profiles in patients with ACL and AVL, they play a dual role in immune modulation in both Leishmania infections 2024-02-01T17:13:09Z 2024-02-01T17:13:09Z 2018-05 article MACÊDO, Bruna de Góis; PEIXOTO, Rephany Fonseca; MACIEL, Bruna Leal Lima; GOMES, Julliana de Assis Silva; AZEVEDO, Fátima de Lourdes Assunção Araújo de; VERAS, Robson Cavalcanti; MEDEIROS, Isac Almeida de; GRISI, Teresa Cristina Soares de Lima; ARAÚJO, Demétrius Antônio Machado de; AMARAL, Ian Porto Gurgel do; LIMA, Tatjana Keesen de Souza. Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios. Scandinavian Journal of Immunology, [S.l.], v. 87, n. 6, p. 1-9, 14 mai. 2018. DOI: 10.1111/sji.12668. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/sji.12668. Acesso em: 30 jan. 2024. https://repositorio.ufrn.br/handle/123456789/57472 http://dx.doi.org/10.1111/sji.12668 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Scandinavian Journal of Immunology |
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Dual immune iNKT cells T cells Visceral leishmaniasis |
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Dual immune iNKT cells T cells Visceral leishmaniasis Maciel, Bruna Leal Lima Macêdo, Bruna de Góis Peixoto, Rephany Fonseca Gomes, Julliana de Assis Silva Azevedo, Fátima de Lourdes Assunção Araújo de Veras, Robson Cavalcanti Medeiros, Isac Almeida de Grisi, Teresa Cristina Soares de Lima Araújo, Demétrius Antônio Machado de Amaral, Ian Porto Gurgel do Lima, Tatjana Keesen de Souza Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios |
| description |
Although the semi-invariant natural killer T cells (iNKT) are a small subpopulation of cells in the peripheral blood, they are presumed to play a role in early stages of infection against various pathogens, including protozoa. This work investigates the activation status and cytokine profile of iNKT cells during human Leishmania infantum and Leishmania braziliensis infection. We studied iNKT cells in patients with symptomatic active visceral leishmaniasis (AVL) (n = 8), patients with symptomatic active cutaneous leishmaniasis (ACL) (n = 13), negative endemic controls (NEC) (n = 6) and non-endemic controls (NonEC) (n = 6), with and without total Leishmania antigen stimulus (TLA). The number of iNKT cells in the peripheral blood of patients with ACL and AVL unaltered in relation to control groups. Moreover, the iNKT cells from ACL showed a hyperactivation profile compared to patients with AVL. Additionally, TLA induced IFN-gamma production in iNKT cells from patients with ACL, while in iNKT of patients with AVL, TLA induced a decrease in this cytokine. Higher IL-17 and IL-10 production by iNKT cells from patients with ACL were also observed compared to all other groups. There were no changes in iNKT IL-10-producing cells in AVL after TLA stimulation. However, TLA induced increase in IL-10 in iNKT cells in patients with ACL. These findings suggest that, although iNKT cells showed distinct profiles in patients with ACL and AVL, they play a dual role in immune modulation in both Leishmania infections |
| format |
article |
| author |
Maciel, Bruna Leal Lima Macêdo, Bruna de Góis Peixoto, Rephany Fonseca Gomes, Julliana de Assis Silva Azevedo, Fátima de Lourdes Assunção Araújo de Veras, Robson Cavalcanti Medeiros, Isac Almeida de Grisi, Teresa Cristina Soares de Lima Araújo, Demétrius Antônio Machado de Amaral, Ian Porto Gurgel do Lima, Tatjana Keesen de Souza |
| author_facet |
Maciel, Bruna Leal Lima Macêdo, Bruna de Góis Peixoto, Rephany Fonseca Gomes, Julliana de Assis Silva Azevedo, Fátima de Lourdes Assunção Araújo de Veras, Robson Cavalcanti Medeiros, Isac Almeida de Grisi, Teresa Cristina Soares de Lima Araújo, Demétrius Antônio Machado de Amaral, Ian Porto Gurgel do Lima, Tatjana Keesen de Souza |
| author_sort |
Maciel, Bruna Leal Lima |
| title |
Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios |
| title_short |
Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios |
| title_full |
Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios |
| title_fullStr |
Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios |
| title_full_unstemmed |
Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios |
| title_sort |
dual immune effect of inkt cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios |
| publisher |
Scandinavian Journal of Immunology |
| publishDate |
2024 |
| url |
https://repositorio.ufrn.br/handle/123456789/57472 http://dx.doi.org/10.1111/sji.12668 |
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| _version_ |
1790055917233897472 |