Produção e caracterização físico-química de gel contendo extrato bruto hidroalcoólico de Cenostigma bracteosum (Tul.) Gagnon & G. P. Lewis

Ethnobotanical studies in the Caatinga have made it possible to describe new species that are sources of molecules with potential biological activity, such as Cenostigma bracteosum, which has antibacterial activity leading to its incorporation into a carbopol 940 gel base, a stable, economically acc...

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Autor principal: Fideles, Marília Gabriela Mamédio
Outros Autores: Ferreira, Leandro De Santis
Formato: bachelorThesis
Idioma:English
Publicado em: Universidade Federal do Rio Grande do Norte
Assuntos:
Cenostigma bracteosum
Hydroalcoholic extract
Formulation
Gel
Stability
CNPQ::CIENCIAS DA SAUDE
CNPQ::CIENCIAS BIOLOGICAS
Endereço do item:https://repositorio.ufrn.br/handle/123456789/56458
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spelling ri-123456789-564582023-12-20T15:46:00Z Produção e caracterização físico-química de gel contendo extrato bruto hidroalcoólico de Cenostigma bracteosum (Tul.) Gagnon & G. P. Lewis Production and physicochemical characterization of gel containing hydroalcoholic crude extract of Cenostigma bracteosum (Tul.) Gagnon & G. P. Lewis Fideles, Marília Gabriela Mamédio Ferreira, Leandro De Santis http://lattes.cnpq.br/6622861873027635 Lima, Waldenice de Alencar Morais http://lattes.cnpq.br/2575667613995470 Silva Júnior, Arnóbio Antônio da Chacon, Daisy Sotero Cenostigma bracteosum Hydroalcoholic extract Formulation Gel Stability CNPQ::CIENCIAS DA SAUDE CNPQ::CIENCIAS BIOLOGICAS Ethnobotanical studies in the Caatinga have made it possible to describe new species that are sources of molecules with potential biological activity, such as Cenostigma bracteosum, which has antibacterial activity leading to its incorporation into a carbopol 940 gel base, a stable, economically accessible and long-release pharmaceutical form. The aim of this study was to develop and evaluate the stability of a gel containing hydroalcoholic extract of Catingueira (C. bracteosum) for topical use on the skin. For this study, the stability of the formulation was assessed over 30 days by analyzing the pH, conductivity, viscosity and spreadability of three samples: the base gel and two other samples with 1% and 3% of the extract, all tests being carried out in triplicate. Both samples remained stable during the analysis time, however, the sample with the 3% extract concentration proved to be more suitable, since it had a pH within the skin's pH range and viscosity and spreadability suitable for topical use, proving to be eligible for future investigations into its potential biological activities and possible cosmetic use. Ethnobotanical studies in the Caatinga have made it possible to describe new species that are sources of molecules with potential biological activity, such as Cenostigma bracteosum, which has antibacterial activity leading to its incorporation into a carbopol 940 gel base, a stable, economically accessible and long-release pharmaceutical form. The aim of this study was to develop and evaluate the stability of a gel containing hydroalcoholic extract of Catingueira (C. bracteosum) for topical use on the skin. For this study, the stability of the formulation was assessed over 30 days by analyzing the pH, conductivity, viscosity and spreadability of three samples: the base gel and two other samples with 1% and 3% of the extract, all tests being carried out in triplicate. Both samples remained stable during the analysis time, however, the sample with the 3% extract concentration proved to be more suitable, since it had a pH within the skin's pH range and viscosity and spreadability suitable for topical use, proving to be eligible for future investigations into its potential biological activities and possible cosmetic use. 2023-12-20T15:45:59Z 2023-12-20T15:45:59Z 2023-12-07 bachelorThesis FIDELES, Marília Gabriela Mamédio. Production and physicochemical characterization of gel containing hydroalcoholic crude extract of Cenostigma bracteosum (Tul.) Gagnon & G. P. Lewis. Orientador: Leandro de Santis Ferreira. 2023. 14 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2023. https://repositorio.ufrn.br/handle/123456789/56458 en Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Universidade Federal do Rio Grande do Norte Brasil UFRN Farmácia Departamento de Farmácia
institution Repositório Institucional
collection RI - UFRN
language English
topic Cenostigma bracteosum
Hydroalcoholic extract
Formulation
Gel
Stability
CNPQ::CIENCIAS DA SAUDE
CNPQ::CIENCIAS BIOLOGICAS
spellingShingle Cenostigma bracteosum
Hydroalcoholic extract
Formulation
Gel
Stability
CNPQ::CIENCIAS DA SAUDE
CNPQ::CIENCIAS BIOLOGICAS
Fideles, Marília Gabriela Mamédio
Produção e caracterização físico-química de gel contendo extrato bruto hidroalcoólico de Cenostigma bracteosum (Tul.) Gagnon & G. P. Lewis
description Ethnobotanical studies in the Caatinga have made it possible to describe new species that are sources of molecules with potential biological activity, such as Cenostigma bracteosum, which has antibacterial activity leading to its incorporation into a carbopol 940 gel base, a stable, economically accessible and long-release pharmaceutical form. The aim of this study was to develop and evaluate the stability of a gel containing hydroalcoholic extract of Catingueira (C. bracteosum) for topical use on the skin. For this study, the stability of the formulation was assessed over 30 days by analyzing the pH, conductivity, viscosity and spreadability of three samples: the base gel and two other samples with 1% and 3% of the extract, all tests being carried out in triplicate. Both samples remained stable during the analysis time, however, the sample with the 3% extract concentration proved to be more suitable, since it had a pH within the skin's pH range and viscosity and spreadability suitable for topical use, proving to be eligible for future investigations into its potential biological activities and possible cosmetic use.
author2 Ferreira, Leandro De Santis
author_facet Ferreira, Leandro De Santis
Fideles, Marília Gabriela Mamédio
format bachelorThesis
author Fideles, Marília Gabriela Mamédio
author_sort Fideles, Marília Gabriela Mamédio
title Produção e caracterização físico-química de gel contendo extrato bruto hidroalcoólico de Cenostigma bracteosum (Tul.) Gagnon & G. P. Lewis
title_short Produção e caracterização físico-química de gel contendo extrato bruto hidroalcoólico de Cenostigma bracteosum (Tul.) Gagnon & G. P. Lewis
title_full Produção e caracterização físico-química de gel contendo extrato bruto hidroalcoólico de Cenostigma bracteosum (Tul.) Gagnon & G. P. Lewis
title_fullStr Produção e caracterização físico-química de gel contendo extrato bruto hidroalcoólico de Cenostigma bracteosum (Tul.) Gagnon & G. P. Lewis
title_full_unstemmed Produção e caracterização físico-química de gel contendo extrato bruto hidroalcoólico de Cenostigma bracteosum (Tul.) Gagnon & G. P. Lewis
title_sort produção e caracterização físico-química de gel contendo extrato bruto hidroalcoólico de cenostigma bracteosum (tul.) gagnon & g. p. lewis
publisher Universidade Federal do Rio Grande do Norte
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/56458
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