Effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type I diabetes

Background and aims: Vascular disease is the principal cause of death and disability in patients with diabetes, and endothelial dysfunction seems to be the major cause in its pathogenesis. Since L-arginine levels are diminished in conditions such as type 1 and type 2 diabetes, in this work we aimed...

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Principais autores: Fayh, Ana Paula Trussardi, Krause, Mauricio, Rodrigues-Krause, Josianne, Ribeiro, Jerri Luiz, Ribeiro, Jorge Pinto, Friedman, Rogério, Moreira, José Cláudio Fonseca, Reischak-Oliveira, Alvaro
Formato: article
Idioma:English
Publicado em: European Journal of Nutrition
Assuntos:
L-Arginine
type 1 diabetes
blood flow
oxidative stress
Endereço do item:https://repositorio.ufrn.br/handle/123456789/55963
https://doi.org/10.1007/s00394-012-0404-7
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spelling ri-123456789-559632023-12-14T23:11:17Z Effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type I diabetes Fayh, Ana Paula Trussardi Krause, Mauricio Rodrigues-Krause, Josianne Ribeiro, Jerri Luiz Ribeiro, Jorge Pinto Friedman, Rogério Moreira, José Cláudio Fonseca Reischak-Oliveira, Alvaro L-Arginine type 1 diabetes blood flow oxidative stress Background and aims: Vascular disease is the principal cause of death and disability in patients with diabetes, and endothelial dysfunction seems to be the major cause in its pathogenesis. Since L-arginine levels are diminished in conditions such as type 1 and type 2 diabetes, in this work we aimed to verify the effects of L-arginine supplementation (7 g/day) over the endothelial function and oxidative stress markers in young male adults with uncomplicated type 1 diabetes. We also investigated the influences of L-arginine administration on vascular/oxidative stress responses to an acute bout of exercise. Methods: Ten young adult male subjects with uncomplicated type 1 diabetes and twenty matched controls volunteered for this study. We analysed the influence of L-arginine supplementation (7 g/day during 1 week) over lower limb blood flow (using a venous occlusion plethysmography technique), oxidative stress marker (TBARS, Carbonyls), anti-oxidant parameters (uric acid and TRAP) and total tNOx in rest conditions and after a single bout of submaximal exercise (VO2 at 10 % below the second ventilatory threshold). Data described as mean ± standard error (SE). Alpha level was P < 0.05. Results: Glycaemic control parameters were altered in type 1 diabetic subjects, such as HbA1c (5.5 ± 0.03 vs. 8.3 ± 0.4 %) and fasted glycaemia (94.8 ± 1.4 vs. 183 ± 19 mg/dL). Oxidative stress/damage markers (carbonyls and TBARS) were increased in the diabetic group, while uric acid was decreased. Rest lower limb blood flow was lower in type 1 diabetic subjects than in healthy controls (3.53 ± 0.35 vs. 2.66 ± 0.3 ml 100 ml−¹ min−¹). L-Arginine supplementation completely recovered basal blood flow to normal levels in type 1 diabetics’ subjects (2.66 ± 0.3 to 4.74 ± 0.86 ml 100 ml−¹ min−¹) but did not interfere in any parameter of redox state or exercise. Conclusion: Our findings highlight the importance of L-arginine for the improvement of vascular function in subjects with diabetes, indicating that L-arginine supplementation could be an essential tool for the treatment for the disease complications, at least in non-complicated diabetes. However, based on our data, it is not possible to draw conclusions regarding the mechanisms by which L-arginine therapy is inducing improvements on cardiovascular function, but this important issue requires further investigations 2023-12-14T23:11:02Z 2023-12-14T23:11:02Z 2013 article FAYH, Ana Paula Trussardi; KRAUSE, Mauricio; RODRIGUES-KRAUSE, Josianne; RIBEIRO, Jerri Luiz; RIBEIRO, Jorge Pinto; FRIEDMAN, Rogério; MOREIRA, José Cláudio Fonseca; REISCHAK-OLIVEIRA, Alvaro. Effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type I diabetes. European Journal of Nutrition, [S.l.], v. 52, p. 975-983, 2013. DOI: 10.1007/s00394-012-0404-7. Disponível em: https://link.springer.com/article/10.1007/s00394-012-0404-7. Acesso em: 14 dez. 2023. https://repositorio.ufrn.br/handle/123456789/55963 https://doi.org/10.1007/s00394-012-0404-7 en European Journal of Nutrition
institution Repositório Institucional
collection RI - UFRN
language English
topic L-Arginine
type 1 diabetes
blood flow
oxidative stress
spellingShingle L-Arginine
type 1 diabetes
blood flow
oxidative stress
Fayh, Ana Paula Trussardi
Krause, Mauricio
Rodrigues-Krause, Josianne
Ribeiro, Jerri Luiz
Ribeiro, Jorge Pinto
Friedman, Rogério
Moreira, José Cláudio Fonseca
Reischak-Oliveira, Alvaro
Effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type I diabetes
description Background and aims: Vascular disease is the principal cause of death and disability in patients with diabetes, and endothelial dysfunction seems to be the major cause in its pathogenesis. Since L-arginine levels are diminished in conditions such as type 1 and type 2 diabetes, in this work we aimed to verify the effects of L-arginine supplementation (7 g/day) over the endothelial function and oxidative stress markers in young male adults with uncomplicated type 1 diabetes. We also investigated the influences of L-arginine administration on vascular/oxidative stress responses to an acute bout of exercise. Methods: Ten young adult male subjects with uncomplicated type 1 diabetes and twenty matched controls volunteered for this study. We analysed the influence of L-arginine supplementation (7 g/day during 1 week) over lower limb blood flow (using a venous occlusion plethysmography technique), oxidative stress marker (TBARS, Carbonyls), anti-oxidant parameters (uric acid and TRAP) and total tNOx in rest conditions and after a single bout of submaximal exercise (VO2 at 10 % below the second ventilatory threshold). Data described as mean ± standard error (SE). Alpha level was P < 0.05. Results: Glycaemic control parameters were altered in type 1 diabetic subjects, such as HbA1c (5.5 ± 0.03 vs. 8.3 ± 0.4 %) and fasted glycaemia (94.8 ± 1.4 vs. 183 ± 19 mg/dL). Oxidative stress/damage markers (carbonyls and TBARS) were increased in the diabetic group, while uric acid was decreased. Rest lower limb blood flow was lower in type 1 diabetic subjects than in healthy controls (3.53 ± 0.35 vs. 2.66 ± 0.3 ml 100 ml−¹ min−¹). L-Arginine supplementation completely recovered basal blood flow to normal levels in type 1 diabetics’ subjects (2.66 ± 0.3 to 4.74 ± 0.86 ml 100 ml−¹ min−¹) but did not interfere in any parameter of redox state or exercise. Conclusion: Our findings highlight the importance of L-arginine for the improvement of vascular function in subjects with diabetes, indicating that L-arginine supplementation could be an essential tool for the treatment for the disease complications, at least in non-complicated diabetes. However, based on our data, it is not possible to draw conclusions regarding the mechanisms by which L-arginine therapy is inducing improvements on cardiovascular function, but this important issue requires further investigations
format article
author Fayh, Ana Paula Trussardi
Krause, Mauricio
Rodrigues-Krause, Josianne
Ribeiro, Jerri Luiz
Ribeiro, Jorge Pinto
Friedman, Rogério
Moreira, José Cláudio Fonseca
Reischak-Oliveira, Alvaro
author_facet Fayh, Ana Paula Trussardi
Krause, Mauricio
Rodrigues-Krause, Josianne
Ribeiro, Jerri Luiz
Ribeiro, Jorge Pinto
Friedman, Rogério
Moreira, José Cláudio Fonseca
Reischak-Oliveira, Alvaro
author_sort Fayh, Ana Paula Trussardi
title Effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type I diabetes
title_short Effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type I diabetes
title_full Effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type I diabetes
title_fullStr Effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type I diabetes
title_full_unstemmed Effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type I diabetes
title_sort effects of l-arginine supplementation on blood flow, oxidative stress status and exercise responses in young adults with uncomplicated type i diabetes
publisher European Journal of Nutrition
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/55963
https://doi.org/10.1007/s00394-012-0404-7
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