Expressão de dupla coloração de p16/ki-67 em citologia líquida em amostras de câncer cervical: uma revisão de escopo
This review aims to present an overview of p16/Ki-67 dual-staining (DS) expression in Liquid Based Cytology (LBC) in samples from patients with cervical cancer (CC). Material and Methods: This scoping review was developed following the guidelines for systematic reviews and meta-analysesfor scopin...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/55878 |
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| Resumo: | This review aims to present an overview of p16/Ki-67 dual-staining (DS)
expression in Liquid Based Cytology (LBC) in samples from patients with cervical
cancer (CC). Material and Methods: This scoping review was developed
following the guidelines for systematic reviews and meta-analysesfor scoping
reviews (PRISMA-ScR). A literature search using PubMed, Lilacs, Web of
Science and Scopus electronic databases was conducted to identify studies that
used DC for expression of p16/Ki-67 in CC in immunocytochemistry in LCB. The
process of selecting and extracting data in a paired and independent way. The
quality of included studies was assessed using the Joanna Briggs Institute Levels
of Evidence. The review was registered in the Open Science Framework (OSF):
DOI 10.17605/OSF.IO/9MUBQ. Results: Of the 149 studies analyzed, 7 studies,
published between January 2018 and May 2023, were included in the qualitative
synthesis. As expression parameters, p16/Ki-67 has been reported for DS in CBL
in CC. Furthermore, we found that p16/Ki-67 in the CBL sample were expressed
in squamous cell carcinoma(SCC). Conclusions: The study suggested that DC
p16/Ki-67 is more frequently related to the CC group when compared to the HSIL
and NILM group. |
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