Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial

Background: The relationship between diabetes and oxidative stress has been previously reported. Exercise represents a useful non-pharmacological strategy for the treatment in type 2 diabetic (T2DM) patients, but high intensity exercise can induce a transient inflammatory state and increase oxidativ...

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Principais autores: Fayh, Ana Paula Trussardi, Sapata, Katiuce Borges, Cunha, Giovani Santos, Krause, Mauricio, Rocha, Ricardo, Bittencourt Júnior, Paulo Ivo Homem de, Moreira, José Cláudio Fonseca, Friedman, Rogério, Rossato, Juliane da Silva, Fernandes, Jõao Roberto, Oliveira, Alvaro Reischak de
Formato: article
Idioma:English
Publicado em: Journal of the International Society of Sports Nutrition
Assuntos:
Omega-3
Type 2 diabetes
Acute exercise
Oxidative stress
Inflammation
Endereço do item:https://repositorio.ufrn.br/handle/123456789/55871
https://doi.org/10.1186/s12970-018-0222-2
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spelling ri-123456789-558712023-12-13T17:18:22Z Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial Fayh, Ana Paula Trussardi Sapata, Katiuce Borges Cunha, Giovani Santos Krause, Mauricio Rocha, Ricardo Bittencourt Júnior, Paulo Ivo Homem de Moreira, José Cláudio Fonseca Friedman, Rogério Rossato, Juliane da Silva Fernandes, Jõao Roberto Oliveira, Alvaro Reischak de Omega-3 Type 2 diabetes Acute exercise Oxidative stress Inflammation Background: The relationship between diabetes and oxidative stress has been previously reported. Exercise represents a useful non-pharmacological strategy for the treatment in type 2 diabetic (T2DM) patients, but high intensity exercise can induce a transient inflammatory state and increase oxidative stress. Nutritional strategies that may contribute to the reduction of oxidative stress induced by acute exercise are necessary. The aim of this study was to examine if n-3 PUFA supplementation intervention can attenuate the inflammatory response and oxidative stress associated with high intensity exercise in this population. As a primary outcome, lipoperoxidation measurements (TBARS and F2-isoprostanes) were selected. Methods: Thirty T2DM patients, without chronic complications, were randomly allocated into two groups: placebo (gelatin capsules) or n-3 PUFA (capsules containing 180 mg of eicosapentaenoic acid and 120 mg of docosahexaenoic acid). Blood samples were collected fasting before and after 8 weeks supplementation. In the beginning and at the end of protocol, an acute exercise was performed (treadmill), and new blood samples were collected before and immediately after the exercise for measurements of oxidative stress and high-sensitivity C-reactive protein (hs-CRP). Results: After the supplementation period, a decrease in triglycerides levels was observed only in n-3 PUFA supplementation group (mean difference and 95% CI of 0.002 (0.000–0.004), p = 0.005). Supplementation also significantly reduced TRAP levels after exercise (mean difference and 95% CI to 9641 (− 20,068–39,351) for − 33,884 (− 56,976 - -10,793), p = 0.004, Cohen’s d effect size = 1.12), but no significant difference was observed in n-3 PUFA supplementation group in lipoperoxidation parameters as TBARS (mean difference and 95% CI to − 3.8 (− 10–2.4) for − 2.9 (− 1.6–7.4) or F2-isoprostanes (mean difference and 95% CI -0.05 (− 0.19–0.10) for − 0.02 (− 0.19–0.16), p > 0.05 for both. Conclusion: PUFA n-3 supplementation reduced triglycerides as well as TRAP levels after exercise, without a significant effect on inflammatory and oxidative stress markers 2023-12-13T17:18:21Z 2023-12-13T17:18:21Z 2018-04 article FAYH, Ana Paula Trussardi; SAPATA, Katiuce Borges; CUNHA, Giovani Santos; KRAUSE, Mauricio; ROCHA, Ricardo; BITTENCOURT JÚNIOR, Paulo Ivo Homem de; MOREIRA, José Cláudio Fonseca; FRIEDMAN, Rogério; ROSSATO, Juliane da Silva; FERNANDES, Jõao Roberto; OLIVEIRA, Alvaro Reischak de. Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial. Journal of the International Society of Sports Nutrition, v. 15, p. 1-9, 13 abr. 2018. DOI: 10.1186/s12970-018-0222-2. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914016. Acesso em: 6 dez. 2023. https://repositorio.ufrn.br/handle/123456789/55871 https://doi.org/10.1186/s12970-018-0222-2 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Journal of the International Society of Sports Nutrition
institution Repositório Institucional
collection RI - UFRN
language English
topic Omega-3
Type 2 diabetes
Acute exercise
Oxidative stress
Inflammation
spellingShingle Omega-3
Type 2 diabetes
Acute exercise
Oxidative stress
Inflammation
Fayh, Ana Paula Trussardi
Sapata, Katiuce Borges
Cunha, Giovani Santos
Krause, Mauricio
Rocha, Ricardo
Bittencourt Júnior, Paulo Ivo Homem de
Moreira, José Cláudio Fonseca
Friedman, Rogério
Rossato, Juliane da Silva
Fernandes, Jõao Roberto
Oliveira, Alvaro Reischak de
Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial
description Background: The relationship between diabetes and oxidative stress has been previously reported. Exercise represents a useful non-pharmacological strategy for the treatment in type 2 diabetic (T2DM) patients, but high intensity exercise can induce a transient inflammatory state and increase oxidative stress. Nutritional strategies that may contribute to the reduction of oxidative stress induced by acute exercise are necessary. The aim of this study was to examine if n-3 PUFA supplementation intervention can attenuate the inflammatory response and oxidative stress associated with high intensity exercise in this population. As a primary outcome, lipoperoxidation measurements (TBARS and F2-isoprostanes) were selected. Methods: Thirty T2DM patients, without chronic complications, were randomly allocated into two groups: placebo (gelatin capsules) or n-3 PUFA (capsules containing 180 mg of eicosapentaenoic acid and 120 mg of docosahexaenoic acid). Blood samples were collected fasting before and after 8 weeks supplementation. In the beginning and at the end of protocol, an acute exercise was performed (treadmill), and new blood samples were collected before and immediately after the exercise for measurements of oxidative stress and high-sensitivity C-reactive protein (hs-CRP). Results: After the supplementation period, a decrease in triglycerides levels was observed only in n-3 PUFA supplementation group (mean difference and 95% CI of 0.002 (0.000–0.004), p = 0.005). Supplementation also significantly reduced TRAP levels after exercise (mean difference and 95% CI to 9641 (− 20,068–39,351) for − 33,884 (− 56,976 - -10,793), p = 0.004, Cohen’s d effect size = 1.12), but no significant difference was observed in n-3 PUFA supplementation group in lipoperoxidation parameters as TBARS (mean difference and 95% CI to − 3.8 (− 10–2.4) for − 2.9 (− 1.6–7.4) or F2-isoprostanes (mean difference and 95% CI -0.05 (− 0.19–0.10) for − 0.02 (− 0.19–0.16), p > 0.05 for both. Conclusion: PUFA n-3 supplementation reduced triglycerides as well as TRAP levels after exercise, without a significant effect on inflammatory and oxidative stress markers
format article
author Fayh, Ana Paula Trussardi
Sapata, Katiuce Borges
Cunha, Giovani Santos
Krause, Mauricio
Rocha, Ricardo
Bittencourt Júnior, Paulo Ivo Homem de
Moreira, José Cláudio Fonseca
Friedman, Rogério
Rossato, Juliane da Silva
Fernandes, Jõao Roberto
Oliveira, Alvaro Reischak de
author_facet Fayh, Ana Paula Trussardi
Sapata, Katiuce Borges
Cunha, Giovani Santos
Krause, Mauricio
Rocha, Ricardo
Bittencourt Júnior, Paulo Ivo Homem de
Moreira, José Cláudio Fonseca
Friedman, Rogério
Rossato, Juliane da Silva
Fernandes, Jõao Roberto
Oliveira, Alvaro Reischak de
author_sort Fayh, Ana Paula Trussardi
title Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial
title_short Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial
title_full Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial
title_fullStr Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial
title_full_unstemmed Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial
title_sort effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic: a randomized clinical trial
publisher Journal of the International Society of Sports Nutrition
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/55871
https://doi.org/10.1186/s12970-018-0222-2
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