Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study

Aim: This study aims to evaluate the effect of early nutritional intervention on adverse clinical events in women with breast cancer undergoing neoadjuvant chemotherapy. Design and settings: This is a randomized clinical trial performed at the beginning of neoadjuvant chemotherapy for women with bre...

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Principais autores: Fayh, Ana Paula Trussardi, Bezerra, Agnes Denise de Lima, Sousa, Iasmin Matias de, Souza, Ana Priscilla Silva de, Carvalho, Ana Lúcia Miranda de
Formato: article
Idioma:English
Publicado em: Clinical Nutrition ESPEN
Assuntos:
Neoplasm
toxicity
diet
nutrition
body weight
disease-free survival
Endereço do item:https://repositorio.ufrn.br/handle/123456789/55832
http://dx.doi.org/10.1016/j.clnesp.2022.12.013
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spelling ri-123456789-558322023-12-13T00:32:15Z Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study Fayh, Ana Paula Trussardi Bezerra, Agnes Denise de Lima Sousa, Iasmin Matias de Souza, Ana Priscilla Silva de Carvalho, Ana Lúcia Miranda de Neoplasm toxicity diet nutrition body weight disease-free survival Aim: This study aims to evaluate the effect of early nutritional intervention on adverse clinical events in women with breast cancer undergoing neoadjuvant chemotherapy. Design and settings: This is a randomized clinical trial performed at the beginning of neoadjuvant chemotherapy for women with breast cancer treated at an oncology referral center (Brazil) and followed until the end of radiotherapy period, at least. Registered under ClinicalTrials.gov Identifier no. RBR3SHHXS. Methods: Participants were allocated to a control group - CG (nutritional guidance on healthy eating practices) or an intervention group - IC (nutritional guidance and individualized food plan). Chemotherapy toxicity (primary endpoint) was considered a precocious adverse clinical event and it was evaluated by self-reported gastrointestinal symptoms observed at any time during the first three cycles of treatment. Post-surgical complications, radiotherapy toxicity, and weight change were considered long-term adverse events. Results: 34 women (19 in the IG and 15 in the CG) were evaluated. The early nutritional intervention was associated with low gastrointestinal chemotoxicity (nausea, vomiting, and constipation, p < 0.001, p < 0.048, and p < 0.024, respectively). However, there were no statically significant differences between both groups in the presence of long-term adverse events (radiotherapy toxicity-88.2% vs 76.9%, weight loss-21.1% vs 26.7% for IC and CG respectively, p > 0.05 for both). Conclusion: The early nutritional intervention was associated with a low frequency of precocious events, but not with long-term adverse events in women with breast cancer during treatment 2023-12-13T00:31:57Z 2023-12-13T00:31:57Z 2023-02 article BEZERRA, Agnes Denise de Lima; SOUSA, Iasmin Matias de; SOUZA, Ana Priscilla Silva de; CARVALHO, Ana Lúcia Miranda de; FAYH, Ana Paula Trussardi. Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study. Clinical Nutrition Espen, [S.l.], v. 53, p. 268-273, fev. 2023. DOI: 10.1016/j.clnesp.2022.12.013. Disponível em: https://www.sciencedirect.com/science/article/pii/S2405457722014231?via%3Dihub. Acesso em: 12 dez. 2023. https://repositorio.ufrn.br/handle/123456789/55832 http://dx.doi.org/10.1016/j.clnesp.2022.12.013 en Clinical Nutrition ESPEN
institution Repositório Institucional
collection RI - UFRN
language English
topic Neoplasm
toxicity
diet
nutrition
body weight
disease-free survival
spellingShingle Neoplasm
toxicity
diet
nutrition
body weight
disease-free survival
Fayh, Ana Paula Trussardi
Bezerra, Agnes Denise de Lima
Sousa, Iasmin Matias de
Souza, Ana Priscilla Silva de
Carvalho, Ana Lúcia Miranda de
Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study
description Aim: This study aims to evaluate the effect of early nutritional intervention on adverse clinical events in women with breast cancer undergoing neoadjuvant chemotherapy. Design and settings: This is a randomized clinical trial performed at the beginning of neoadjuvant chemotherapy for women with breast cancer treated at an oncology referral center (Brazil) and followed until the end of radiotherapy period, at least. Registered under ClinicalTrials.gov Identifier no. RBR3SHHXS. Methods: Participants were allocated to a control group - CG (nutritional guidance on healthy eating practices) or an intervention group - IC (nutritional guidance and individualized food plan). Chemotherapy toxicity (primary endpoint) was considered a precocious adverse clinical event and it was evaluated by self-reported gastrointestinal symptoms observed at any time during the first three cycles of treatment. Post-surgical complications, radiotherapy toxicity, and weight change were considered long-term adverse events. Results: 34 women (19 in the IG and 15 in the CG) were evaluated. The early nutritional intervention was associated with low gastrointestinal chemotoxicity (nausea, vomiting, and constipation, p < 0.001, p < 0.048, and p < 0.024, respectively). However, there were no statically significant differences between both groups in the presence of long-term adverse events (radiotherapy toxicity-88.2% vs 76.9%, weight loss-21.1% vs 26.7% for IC and CG respectively, p > 0.05 for both). Conclusion: The early nutritional intervention was associated with a low frequency of precocious events, but not with long-term adverse events in women with breast cancer during treatment
format article
author Fayh, Ana Paula Trussardi
Bezerra, Agnes Denise de Lima
Sousa, Iasmin Matias de
Souza, Ana Priscilla Silva de
Carvalho, Ana Lúcia Miranda de
author_facet Fayh, Ana Paula Trussardi
Bezerra, Agnes Denise de Lima
Sousa, Iasmin Matias de
Souza, Ana Priscilla Silva de
Carvalho, Ana Lúcia Miranda de
author_sort Fayh, Ana Paula Trussardi
title Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study
title_short Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study
title_full Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study
title_fullStr Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study
title_full_unstemmed Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study
title_sort early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study
publisher Clinical Nutrition ESPEN
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/55832
http://dx.doi.org/10.1016/j.clnesp.2022.12.013
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