Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study

Purpose Sarcopenia is a muscle dysfunction that increases negative outcomes in patients with cancer. However, its diagnosis remains uncommon in clinical practice. The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) is a questionnaire to assess the functional status, but it is unknown...

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Principais autores: Fayh, Ana Paula Trussardi, Sousa, Iasmin Matias
Formato: article
Idioma:English
Publicado em: Supportive Care In Cancer
Assuntos:
Sarcopenia
mortality
nutritional assessment
performance status
cancer
Endereço do item:https://repositorio.ufrn.br/handle/123456789/55765
http://dx.doi.org/10.1007/s00520-023-07845-w
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spelling ri-123456789-557652023-12-12T00:12:18Z Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study Fayh, Ana Paula Trussardi Sousa, Iasmin Matias Sarcopenia mortality nutritional assessment performance status cancer Purpose Sarcopenia is a muscle dysfunction that increases negative outcomes in patients with cancer. However, its diagnosis remains uncommon in clinical practice. The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) is a questionnaire to assess the functional status, but it is unknown if is comparable with sarcopenia. We aimed at comparing ECOG-PS with sarcopenia to predict 12-month mortality in patients with cancer. Methods Cohort study including older adult patients with cancer in treatment (any stage of the disease or treatment) at a reference hospital for oncological care. Socio-demographic, clinical, and anthropometric data, muscle mass, and physical function variables (handgrip strength [HGS] and gait speed [GS]) were collected. Skeletal muscle quantity and quality were assessed by computed tomography at the L3. Sarcopenia was diagnosed according to the EWGSP2. ECOG-PS and all-cause mortality were evaluated. The Cox proportional hazards model was calculated. Results We evaluated 159 patients (69 years old, 55% males). Low performance (ECOG-PS≥2) was found in 23.3%, 35.8% presented sarcopenia, and 22.0% severe sarcopenia. ECOG-PS≥2 was not an independent predictor of mortality. Sarcopenia, severe sarcopenia, and probable sarcopenia has increased by 3.25 (confdence interval, CI 95% 1.55–6.80), 2.64 (CI 95% 1.23–5.67), and 2.81 (CI 95% 1.30–6.07) times the risk of mortality, respectively. Conclusion Sarcopenia, but not ECOG-PS, was a predictor of mortality. Therefore, ECOG-PS was not similar to sarcopenia to predict mortality in patients with cancer 2023-12-12T00:10:50Z 2023-12-12T00:10:50Z 2023-06 article SOUSA, Iasmin Matias; FAYH, Ana Paula Trussardi. Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study. Supportive Care In Cancer, [S.l.], v. 31, p. 370, 2 jun. 2023. DOI: 10.1007/s00520-023-07845-w. Disponível em: https://link.springer.com/article/10.1007/s00520-023-07845-w. Acesso em: 11 dez. 2023. https://repositorio.ufrn.br/handle/123456789/55765 http://dx.doi.org/10.1007/s00520-023-07845-w en Supportive Care In Cancer
institution Repositório Institucional
collection RI - UFRN
language English
topic Sarcopenia
mortality
nutritional assessment
performance status
cancer
spellingShingle Sarcopenia
mortality
nutritional assessment
performance status
cancer
Fayh, Ana Paula Trussardi
Sousa, Iasmin Matias
Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study
description Purpose Sarcopenia is a muscle dysfunction that increases negative outcomes in patients with cancer. However, its diagnosis remains uncommon in clinical practice. The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) is a questionnaire to assess the functional status, but it is unknown if is comparable with sarcopenia. We aimed at comparing ECOG-PS with sarcopenia to predict 12-month mortality in patients with cancer. Methods Cohort study including older adult patients with cancer in treatment (any stage of the disease or treatment) at a reference hospital for oncological care. Socio-demographic, clinical, and anthropometric data, muscle mass, and physical function variables (handgrip strength [HGS] and gait speed [GS]) were collected. Skeletal muscle quantity and quality were assessed by computed tomography at the L3. Sarcopenia was diagnosed according to the EWGSP2. ECOG-PS and all-cause mortality were evaluated. The Cox proportional hazards model was calculated. Results We evaluated 159 patients (69 years old, 55% males). Low performance (ECOG-PS≥2) was found in 23.3%, 35.8% presented sarcopenia, and 22.0% severe sarcopenia. ECOG-PS≥2 was not an independent predictor of mortality. Sarcopenia, severe sarcopenia, and probable sarcopenia has increased by 3.25 (confdence interval, CI 95% 1.55–6.80), 2.64 (CI 95% 1.23–5.67), and 2.81 (CI 95% 1.30–6.07) times the risk of mortality, respectively. Conclusion Sarcopenia, but not ECOG-PS, was a predictor of mortality. Therefore, ECOG-PS was not similar to sarcopenia to predict mortality in patients with cancer
format article
author Fayh, Ana Paula Trussardi
Sousa, Iasmin Matias
author_facet Fayh, Ana Paula Trussardi
Sousa, Iasmin Matias
author_sort Fayh, Ana Paula Trussardi
title Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study
title_short Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study
title_full Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study
title_fullStr Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study
title_full_unstemmed Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study
title_sort is the ecog-ps similar to the sarcopenia status for predicting mortality in older adults with cancer? a prospective cohort study
publisher Supportive Care In Cancer
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/55765
http://dx.doi.org/10.1007/s00520-023-07845-w
work_keys_str_mv AT fayhanapaulatrussardi istheecogpssimilartothesarcopeniastatusforpredictingmortalityinolderadultswithcanceraprospectivecohortstudy
AT sousaiasminmatias istheecogpssimilartothesarcopeniastatusforpredictingmortalityinolderadultswithcanceraprospectivecohortstudy
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