Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study

BackgroundChemotherapy is an effective treatment with good clinical response in patients with cancer. However, it cancause exacerbated toxicities in patients and consequently change the course of treatment. Some factors may interfere withthis toxicity such as body composition, especially in gastroin...

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Principais autores: Fayh, Ana Paula Trussardi, Rocha, Ilanna Marques Gomes da, Marcadenti, Aline, Medeiros, Galtieri Otávio Cunha de, Bezerra, Ricardo Andrade, Rego, Juliana Florinda de Mendonça, Gonzalez, Maria Cristina
Formato: article
Idioma:English
Publicado em: Journal of Cachexia, Sarcopenia and Muscle
Assuntos:
Sarcopenia
cachexia
muscle attenuation
chemotherapy toxicity
nutritional status
gastrointestinal cancer
Endereço do item:https://repositorio.ufrn.br/handle/123456789/55476
http://dx.doi.org/10.1002/jcsm.12391
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spelling ri-123456789-554762023-11-28T21:56:26Z Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study Fayh, Ana Paula Trussardi Rocha, Ilanna Marques Gomes da Marcadenti, Aline Medeiros, Galtieri Otávio Cunha de Bezerra, Ricardo Andrade Rego, Juliana Florinda de Mendonça Gonzalez, Maria Cristina Sarcopenia cachexia muscle attenuation chemotherapy toxicity nutritional status gastrointestinal cancer BackgroundChemotherapy is an effective treatment with good clinical response in patients with cancer. However, it cancause exacerbated toxicities in patients and consequently change the course of treatment. Some factors may interfere withthis toxicity such as body composition, especially in gastrointestinal cancer. The aim of this study was to evaluate the effectsof body composition, nutritional status, and functional capacity scale in predicting the occurrence of toxicities in gastrointes-tinal cancer patients during chemotherapy treatment.MethodsThis is a prospective study with gastrointestinal cancer patients at the beginning of chemotherapy treatment.Sarcopenia and muscle attenuation were assessed using the skeletal muscle index from computerized tomography by measur-ing cross-sectional areas of the L3tissue (cm2/m2). Cachexia was graded according to involuntary weight loss associated withsarcopenia. Nutritional status was assessed by using anthropometric evaluation and Patient-Generated Subjective Global As-sessment. Functional capacity was evaluated by handgrip strength and Eastern Cooperative Oncology Group (ECOG) Perfor-mance Status scale. Haematological gastrointestinal and dose-limiting toxicities (DLTs) were defined according to NationalCancer Institute Common Toxicity Criteria. The associations among sarcopenia, cachexia, nutritional status, and functional ca-pacity with DLT were assessed by univariate and multivariate Cox regression model.ResultsA total of60patients were evaluated (55% male,60.9±14.0years) and followed up for a mean of55days. Mostpatients had normal weight (44.2%) and good ECOG Performance Status (≤1) at baseline (78%). During the chemotherapy pe-riod, the most prevalent toxicities were diarrhoea, nausea, and anorexia, but the presence of DLT was similar between cycles(P>0.05). Cachexia was associated with a higher toxicity manifested by diarrhoea (P=0.02), nausea (P=0.02), and anorexia(P<0.01andP=0.03at Cycles1and2, respectively). Sarcopenic and cachetic individuals experienced more toxicities and DLTduring chemotherapy. The only factors associated with DLT in the multivariate Cox regression analyses including the presenceof metastasis and the chemotherapy protocol were cachexia and the ECOG scale (P<0.001for both).ConclusionsCachexia and ECOG score may identify patients with an increased risk for developing severe toxicity events dur-ing chemotherapy treatment for gastrointestinal cancer 2023-11-28T21:55:40Z 2023-11-28T21:55:40Z 2019-03 article ROCHA, Ilanna Marques Gomes da; MARCADENTI, Aline; MEDEIROS, Galtieri Otávio Cunha de; BEZERRA, Ricardo Andrade; REGO, Juliana Florinda de Mendonça; GONZALEZ, Maria Cristina; FAYH, Ana Paula Trussardi. Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study. Journal Of Cachexia, Sarcopenia And Muscle, [S.l.], v. 10, n. 2, p. 445-454, 28 mar. 2019. DOI: 10.1002/jcsm.12391. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/jcsm.12391. Acesso em: 28 nov. 2023. https://repositorio.ufrn.br/handle/123456789/55476 http://dx.doi.org/10.1002/jcsm.12391 en Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Journal of Cachexia, Sarcopenia and Muscle
institution Repositório Institucional
collection RI - UFRN
language English
topic Sarcopenia
cachexia
muscle attenuation
chemotherapy toxicity
nutritional status
gastrointestinal cancer
spellingShingle Sarcopenia
cachexia
muscle attenuation
chemotherapy toxicity
nutritional status
gastrointestinal cancer
Fayh, Ana Paula Trussardi
Rocha, Ilanna Marques Gomes da
Marcadenti, Aline
Medeiros, Galtieri Otávio Cunha de
Bezerra, Ricardo Andrade
Rego, Juliana Florinda de Mendonça
Gonzalez, Maria Cristina
Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study
description BackgroundChemotherapy is an effective treatment with good clinical response in patients with cancer. However, it cancause exacerbated toxicities in patients and consequently change the course of treatment. Some factors may interfere withthis toxicity such as body composition, especially in gastrointestinal cancer. The aim of this study was to evaluate the effectsof body composition, nutritional status, and functional capacity scale in predicting the occurrence of toxicities in gastrointes-tinal cancer patients during chemotherapy treatment.MethodsThis is a prospective study with gastrointestinal cancer patients at the beginning of chemotherapy treatment.Sarcopenia and muscle attenuation were assessed using the skeletal muscle index from computerized tomography by measur-ing cross-sectional areas of the L3tissue (cm2/m2). Cachexia was graded according to involuntary weight loss associated withsarcopenia. Nutritional status was assessed by using anthropometric evaluation and Patient-Generated Subjective Global As-sessment. Functional capacity was evaluated by handgrip strength and Eastern Cooperative Oncology Group (ECOG) Perfor-mance Status scale. Haematological gastrointestinal and dose-limiting toxicities (DLTs) were defined according to NationalCancer Institute Common Toxicity Criteria. The associations among sarcopenia, cachexia, nutritional status, and functional ca-pacity with DLT were assessed by univariate and multivariate Cox regression model.ResultsA total of60patients were evaluated (55% male,60.9±14.0years) and followed up for a mean of55days. Mostpatients had normal weight (44.2%) and good ECOG Performance Status (≤1) at baseline (78%). During the chemotherapy pe-riod, the most prevalent toxicities were diarrhoea, nausea, and anorexia, but the presence of DLT was similar between cycles(P>0.05). Cachexia was associated with a higher toxicity manifested by diarrhoea (P=0.02), nausea (P=0.02), and anorexia(P<0.01andP=0.03at Cycles1and2, respectively). Sarcopenic and cachetic individuals experienced more toxicities and DLTduring chemotherapy. The only factors associated with DLT in the multivariate Cox regression analyses including the presenceof metastasis and the chemotherapy protocol were cachexia and the ECOG scale (P<0.001for both).ConclusionsCachexia and ECOG score may identify patients with an increased risk for developing severe toxicity events dur-ing chemotherapy treatment for gastrointestinal cancer
format article
author Fayh, Ana Paula Trussardi
Rocha, Ilanna Marques Gomes da
Marcadenti, Aline
Medeiros, Galtieri Otávio Cunha de
Bezerra, Ricardo Andrade
Rego, Juliana Florinda de Mendonça
Gonzalez, Maria Cristina
author_facet Fayh, Ana Paula Trussardi
Rocha, Ilanna Marques Gomes da
Marcadenti, Aline
Medeiros, Galtieri Otávio Cunha de
Bezerra, Ricardo Andrade
Rego, Juliana Florinda de Mendonça
Gonzalez, Maria Cristina
author_sort Fayh, Ana Paula Trussardi
title Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study
title_short Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study
title_full Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study
title_fullStr Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study
title_full_unstemmed Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study
title_sort is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study
publisher Journal of Cachexia, Sarcopenia and Muscle
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/55476
http://dx.doi.org/10.1002/jcsm.12391
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