Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI study

Ethnopharmacological relevance: Ayahuasca is a beverage used in Amazonian traditional medicine and it has been part of the human experience for millennia as well as other different psychoactive plants. Although Ayahuasca has been proposed as potentially therapeutic as an anxiolytic and antidepressan...

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Principais autores: Sanchez, Tiago Arruda, Ramos, Lucas Rego, Araujo, Felipe, Schenberg, Eduardo Ekman, Yonamine, Mauricio, Lobo, Isabela, Araujo, Draulio Barros de, Luna, Luis Eduardo
Formato: article
Idioma:English
Publicado em: Elsevier BV
Assuntos:
ayahuasca
banisteriopsis
dimethyltryptamine
N,N-Dimethyltryptamine
emotion
harmine
psychedelic
hallucinogens
fMRI
magnetic Resonance Imaging
Endereço do item:https://repositorio.ufrn.br/handle/123456789/55426
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spelling ri-123456789-554262023-11-24T15:23:29Z Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI study Sanchez, Tiago Arruda Ramos, Lucas Rego Araujo, Felipe Schenberg, Eduardo Ekman Yonamine, Mauricio Lobo, Isabela Araujo, Draulio Barros de Luna, Luis Eduardo ayahuasca banisteriopsis dimethyltryptamine N,N-Dimethyltryptamine emotion harmine psychedelic hallucinogens fMRI magnetic Resonance Imaging Ethnopharmacological relevance: Ayahuasca is a beverage used in Amazonian traditional medicine and it has been part of the human experience for millennia as well as other different psychoactive plants. Although Ayahuasca has been proposed as potentially therapeutic as an anxiolytic and antidepressant, whilst no studies have been carried out so far investigating their direct effect on brain emotional processing. Aim of the study: This study aimed to measure the emotional acute effect of Ayahuasca on brain response to implicit aversive stimulation using a face recognition task in functional magnetic resonance imaging (fMRI). Materials and methods: Nineteen male experienced Ayahuasca users participated in this study in two fMRI sessions before and after 50 min of the Ayahuasca ingestion. Subjects were presented with pictures of neutral (A) and aversive (B) (fearful or disgusted) faces from the Pictures of Facial Affect Series. Subjects were instructed to identify the gender of the faces (gender discrimination task) while the emotional content was implicit. Subjective mood states were also evaluated before Ayahuasca intake and after the second fMRI session, using a visual analogue mood scale (VAMS). Results: During the aversive stimuli, the activity in the bilateral amygdala was attenuated by Ayahuasca (qFDR<0.05). Furthermore, in an exploratory analysis of the effects after intake, Ayahuasca enhances the activation bilaterally in the insula, as well as in the right dorsolateral prefrontal cortex (qFDR<0.05). In the psychometric VAMS scale, subjects reported attenuation of both anxiety and mental sedation (p < 0.01) during acute effects. Conclusions: Together, all reported results including neuroimaging, behavioral data and psychometric self-report suggest that Ayahuasca can promote an emotion regulation mechanism in response to aversive stimuli with corresponding improved cognition including reduced anxiety and mental sedation 2023-11-24T15:23:10Z 2023-11-24T15:23:10Z 2023-11 article SANCHEZ, Tiago Arruda; RAMOS, Lucas Rego; ARAUJO, Felipe; SCHENBERG, Eduardo Ekman; YONAMINE, Mauricio; LOBO, Isabela; ARAUJO, Draulio Barros de; LUNA, Luis Eduardo. Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: An fmri study. Journal of Ethnopharmacology, [S. l.], p. 117430, nov. 2023. DOI http://dx.doi.org/10.1016/j.jep.2023.117430. Disponível em: https://www.sciencedirect.com/science/article/pii/S0378874123013004?via%3Dihub. Acesso em: 22 nov. 2023. e1872-7573 https://repositorio.ufrn.br/handle/123456789/55426 10.1016/j.jep.2023.117430 en Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Elsevier BV
institution Repositório Institucional
collection RI - UFRN
language English
topic ayahuasca
banisteriopsis
dimethyltryptamine
N,N-Dimethyltryptamine
emotion
harmine
psychedelic
hallucinogens
fMRI
magnetic Resonance Imaging
spellingShingle ayahuasca
banisteriopsis
dimethyltryptamine
N,N-Dimethyltryptamine
emotion
harmine
psychedelic
hallucinogens
fMRI
magnetic Resonance Imaging
Sanchez, Tiago Arruda
Ramos, Lucas Rego
Araujo, Felipe
Schenberg, Eduardo Ekman
Yonamine, Mauricio
Lobo, Isabela
Araujo, Draulio Barros de
Luna, Luis Eduardo
Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI study
description Ethnopharmacological relevance: Ayahuasca is a beverage used in Amazonian traditional medicine and it has been part of the human experience for millennia as well as other different psychoactive plants. Although Ayahuasca has been proposed as potentially therapeutic as an anxiolytic and antidepressant, whilst no studies have been carried out so far investigating their direct effect on brain emotional processing. Aim of the study: This study aimed to measure the emotional acute effect of Ayahuasca on brain response to implicit aversive stimulation using a face recognition task in functional magnetic resonance imaging (fMRI). Materials and methods: Nineteen male experienced Ayahuasca users participated in this study in two fMRI sessions before and after 50 min of the Ayahuasca ingestion. Subjects were presented with pictures of neutral (A) and aversive (B) (fearful or disgusted) faces from the Pictures of Facial Affect Series. Subjects were instructed to identify the gender of the faces (gender discrimination task) while the emotional content was implicit. Subjective mood states were also evaluated before Ayahuasca intake and after the second fMRI session, using a visual analogue mood scale (VAMS). Results: During the aversive stimuli, the activity in the bilateral amygdala was attenuated by Ayahuasca (qFDR<0.05). Furthermore, in an exploratory analysis of the effects after intake, Ayahuasca enhances the activation bilaterally in the insula, as well as in the right dorsolateral prefrontal cortex (qFDR<0.05). In the psychometric VAMS scale, subjects reported attenuation of both anxiety and mental sedation (p < 0.01) during acute effects. Conclusions: Together, all reported results including neuroimaging, behavioral data and psychometric self-report suggest that Ayahuasca can promote an emotion regulation mechanism in response to aversive stimuli with corresponding improved cognition including reduced anxiety and mental sedation
format article
author Sanchez, Tiago Arruda
Ramos, Lucas Rego
Araujo, Felipe
Schenberg, Eduardo Ekman
Yonamine, Mauricio
Lobo, Isabela
Araujo, Draulio Barros de
Luna, Luis Eduardo
author_facet Sanchez, Tiago Arruda
Ramos, Lucas Rego
Araujo, Felipe
Schenberg, Eduardo Ekman
Yonamine, Mauricio
Lobo, Isabela
Araujo, Draulio Barros de
Luna, Luis Eduardo
author_sort Sanchez, Tiago Arruda
title Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI study
title_short Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI study
title_full Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI study
title_fullStr Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI study
title_full_unstemmed Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI study
title_sort emotion regulation effects of ayahuasca in experienced subjects during implicit aversive stimulation: an fmri study
publisher Elsevier BV
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/55426
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