Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction

The increasing prevalence of obesity and, consequently, chronic inflammation and its complications has increased the search for new treatment methods. The effect of the purified tamarind seed trypsin inhibitor (TTIp) on metabolic alterations in Wistar rats with obesity and dyslipidemia was evaluated...

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Principais autores: Morais, Ana Heloneida de Araújo, Carvalho, Fabiana Maria Coimbra de, Lima, Vanessa Cristina Oliveira de, Costa, Izael Souza, Luz, Anna Beatriz Santana, Ladd, Fernando Vagner Lobo, Serquiz, Alexandre Coelho, Bortolin, Raul Hernandes, Silbiger, Vivian Nogueira, Maciel, Bruna Leal Lima, Santos, Elizeu Antunes dos
Outros Autores: https://orcid.org/0000-0002-6460-911X
Formato: article
Idioma:English
Publicado em: Nutrients
Assuntos:
Inflammation
tamarindus indica L.
triglycerides
VLDL
Endereço do item:https://repositorio.ufrn.br/handle/123456789/54665
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spelling ri-123456789-546652023-09-01T21:27:45Z Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction Morais, Ana Heloneida de Araújo Carvalho, Fabiana Maria Coimbra de Lima, Vanessa Cristina Oliveira de Costa, Izael Souza Luz, Anna Beatriz Santana Ladd, Fernando Vagner Lobo Serquiz, Alexandre Coelho Bortolin, Raul Hernandes Silbiger, Vivian Nogueira Maciel, Bruna Leal Lima Santos, Elizeu Antunes dos https://orcid.org/0000-0002-6460-911X Inflammation tamarindus indica L. triglycerides VLDL The increasing prevalence of obesity and, consequently, chronic inflammation and its complications has increased the search for new treatment methods. The effect of the purified tamarind seed trypsin inhibitor (TTIp) on metabolic alterations in Wistar rats with obesity and dyslipidemia was evaluated. Three groups of animals with obesity and dyslipidemia were formed, consuming a high glycemic index and glycemic load (HGLI) diet, for 10 days: Obese/HGLI diet; Obese/standard diet; Obese/HGLI diet + TTIp (730 µg/kg); and one eutrophic group of animals was fed a standard diet. Rats were evaluated daily for food intake and weight gain. On the 11th day, animals were anesthetized and sacrificed for blood and visceral adipose tissue collection. TTIp treated animals presented significantly lower food intake than the untreated group (p = 0.0065), TG (76.20 ± 18.73 mg/dL) and VLDL-C (15.24 ± 3.75 mg/dL). Plasma concentrations and TNF-α mRNA expression in visceral adipose tissue also decreased in obese animals treated with TTIp (p < 0.05 and p = 0.025, respectively) with a negative immunostaining. We conclude that TTIp presented anti-TNF-α activity and an improved lipid profile of Wistar rats with dyslipidemia and obesity induced by a high glycemic index and load diet regardless of PPAR-γ induction. 2023-09-01T21:27:45Z 2023-09-01T21:27:45Z 2019 article CARVALHO, Fabiana Maria Coimbra de. Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction. Nutrients, v. 11, n. 3, p. 512, 2019. Disponível em: https://www.mdpi.com/2072-6643/11/3/512. Acesso em: 5 jul. 2023 https://repositorio.ufrn.br/handle/123456789/54665 10.3390/nu11030512 en application/pdf Nutrients
institution Repositório Institucional
collection RI - UFRN
language English
topic Inflammation
tamarindus indica L.
triglycerides
VLDL
spellingShingle Inflammation
tamarindus indica L.
triglycerides
VLDL
Morais, Ana Heloneida de Araújo
Carvalho, Fabiana Maria Coimbra de
Lima, Vanessa Cristina Oliveira de
Costa, Izael Souza
Luz, Anna Beatriz Santana
Ladd, Fernando Vagner Lobo
Serquiz, Alexandre Coelho
Bortolin, Raul Hernandes
Silbiger, Vivian Nogueira
Maciel, Bruna Leal Lima
Santos, Elizeu Antunes dos
Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction
description The increasing prevalence of obesity and, consequently, chronic inflammation and its complications has increased the search for new treatment methods. The effect of the purified tamarind seed trypsin inhibitor (TTIp) on metabolic alterations in Wistar rats with obesity and dyslipidemia was evaluated. Three groups of animals with obesity and dyslipidemia were formed, consuming a high glycemic index and glycemic load (HGLI) diet, for 10 days: Obese/HGLI diet; Obese/standard diet; Obese/HGLI diet + TTIp (730 µg/kg); and one eutrophic group of animals was fed a standard diet. Rats were evaluated daily for food intake and weight gain. On the 11th day, animals were anesthetized and sacrificed for blood and visceral adipose tissue collection. TTIp treated animals presented significantly lower food intake than the untreated group (p = 0.0065), TG (76.20 ± 18.73 mg/dL) and VLDL-C (15.24 ± 3.75 mg/dL). Plasma concentrations and TNF-α mRNA expression in visceral adipose tissue also decreased in obese animals treated with TTIp (p < 0.05 and p = 0.025, respectively) with a negative immunostaining. We conclude that TTIp presented anti-TNF-α activity and an improved lipid profile of Wistar rats with dyslipidemia and obesity induced by a high glycemic index and load diet regardless of PPAR-γ induction.
author2 https://orcid.org/0000-0002-6460-911X
author_facet https://orcid.org/0000-0002-6460-911X
Morais, Ana Heloneida de Araújo
Carvalho, Fabiana Maria Coimbra de
Lima, Vanessa Cristina Oliveira de
Costa, Izael Souza
Luz, Anna Beatriz Santana
Ladd, Fernando Vagner Lobo
Serquiz, Alexandre Coelho
Bortolin, Raul Hernandes
Silbiger, Vivian Nogueira
Maciel, Bruna Leal Lima
Santos, Elizeu Antunes dos
format article
author Morais, Ana Heloneida de Araújo
Carvalho, Fabiana Maria Coimbra de
Lima, Vanessa Cristina Oliveira de
Costa, Izael Souza
Luz, Anna Beatriz Santana
Ladd, Fernando Vagner Lobo
Serquiz, Alexandre Coelho
Bortolin, Raul Hernandes
Silbiger, Vivian Nogueira
Maciel, Bruna Leal Lima
Santos, Elizeu Antunes dos
author_sort Morais, Ana Heloneida de Araújo
title Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction
title_short Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction
title_full Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction
title_fullStr Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction
title_full_unstemmed Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction
title_sort anti-tnf-α agent tamarind kunitz trypsin inhibitor improves lipid profile of wistar rats presenting dyslipidemia and diet-induced obesity regardless of ppar-γ induction
publisher Nutrients
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/54665
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