Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation

The safety and bioactive potential of crude carotenoid extract from Cantaloupe melon nanoencapsulated in porcine gelatin (EPG) were evaluated in a chronic inflammatory experimental model. Animals were fed a high glycemic index and high glycemic load (HGLI) diet for 17 weeks and treated for ten day...

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Principais autores: Morais, Ana Heloneida de Araújo, Medeiros, Isaiane, Oliveira, Grazielle Louise Ribeiro de, Queiroz, Jaluza Luana Carvalho de, Gomes, Camila de Carvalho, Carvalho, Fabiana Maria Coimbra de, Lima, Maíra Conceição Jerônimo de Souza, Serquiz, Alexandre Coelho, Santos, Pedro Paulo de Andrade, Camillo, Christina da Silva, Maciel, Bruna Leal Lima, Passos, Thaís Souza
Outros Autores: https://orcid.org/0000-0002-6460-911X
Formato: article
Idioma:English
Publicado em: Elsevier
Assuntos:
β-carotene
curcubitaceae
nanotechnology
toxicity
obesity
Endereço do item:https://repositorio.ufrn.br/handle/123456789/54626
https://doi.org/10.1016/j.btre.2020.e00567
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spelling ri-123456789-546262023-08-28T21:26:46Z Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation Morais, Ana Heloneida de Araújo Medeiros, Isaiane Oliveira, Grazielle Louise Ribeiro de Queiroz, Jaluza Luana Carvalho de Gomes, Camila de Carvalho Carvalho, Fabiana Maria Coimbra de Lima, Maíra Conceição Jerônimo de Souza Serquiz, Alexandre Coelho Santos, Pedro Paulo de Andrade Camillo, Christina da Silva Maciel, Bruna Leal Lima Passos, Thaís Souza https://orcid.org/0000-0002-6460-911X β-carotene curcubitaceae nanotechnology toxicity obesity The safety and bioactive potential of crude carotenoid extract from Cantaloupe melon nanoencapsulated in porcine gelatin (EPG) were evaluated in a chronic inflammatory experimental model. Animals were fed a high glycemic index and high glycemic load (HGLI) diet for 17 weeks and treated for ten days with 1) HGLI diet, 2) standard diet, 3) HGLI diet + crude carotenoid extract (CE) (12.5 mg/kg), and 4) HGLI diet + EPG (50 mg/kg). General toxicity signals were investigated, considering body weight, food intake, hematological, biochemical parameters, relative weight, morphology, and histopathology of organs. The biochemical parameters indicated the low toxicity of EPG. Acute hepatitis was observed in animals' livers, but CE and EPG groups presented improved tissue appearance. Chronic enteritis was observed in animals, with villi and intestinal glands preservation in the EPG group. The results suggest the safety and the bioactive effect of EPG, possibly related to its anti-inflammatory potential 2023-08-28T21:26:46Z 2023-08-28T21:26:46Z 2020 article MEDEIROS, Isaiane et al. Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation. Biotechnology Reports, v. 28, p. e00567, 2020.Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S2215017X20308298. Acesso em: 5 jul. 2023. https://repositorio.ufrn.br/handle/123456789/54626 https://doi.org/10.1016/j.btre.2020.e00567 en Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Elsevier
institution Repositório Institucional
collection RI - UFRN
language English
topic β-carotene
curcubitaceae
nanotechnology
toxicity
obesity
spellingShingle β-carotene
curcubitaceae
nanotechnology
toxicity
obesity
Morais, Ana Heloneida de Araújo
Medeiros, Isaiane
Oliveira, Grazielle Louise Ribeiro de
Queiroz, Jaluza Luana Carvalho de
Gomes, Camila de Carvalho
Carvalho, Fabiana Maria Coimbra de
Lima, Maíra Conceição Jerônimo de Souza
Serquiz, Alexandre Coelho
Santos, Pedro Paulo de Andrade
Camillo, Christina da Silva
Maciel, Bruna Leal Lima
Passos, Thaís Souza
Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation
description The safety and bioactive potential of crude carotenoid extract from Cantaloupe melon nanoencapsulated in porcine gelatin (EPG) were evaluated in a chronic inflammatory experimental model. Animals were fed a high glycemic index and high glycemic load (HGLI) diet for 17 weeks and treated for ten days with 1) HGLI diet, 2) standard diet, 3) HGLI diet + crude carotenoid extract (CE) (12.5 mg/kg), and 4) HGLI diet + EPG (50 mg/kg). General toxicity signals were investigated, considering body weight, food intake, hematological, biochemical parameters, relative weight, morphology, and histopathology of organs. The biochemical parameters indicated the low toxicity of EPG. Acute hepatitis was observed in animals' livers, but CE and EPG groups presented improved tissue appearance. Chronic enteritis was observed in animals, with villi and intestinal glands preservation in the EPG group. The results suggest the safety and the bioactive effect of EPG, possibly related to its anti-inflammatory potential
author2 https://orcid.org/0000-0002-6460-911X
author_facet https://orcid.org/0000-0002-6460-911X
Morais, Ana Heloneida de Araújo
Medeiros, Isaiane
Oliveira, Grazielle Louise Ribeiro de
Queiroz, Jaluza Luana Carvalho de
Gomes, Camila de Carvalho
Carvalho, Fabiana Maria Coimbra de
Lima, Maíra Conceição Jerônimo de Souza
Serquiz, Alexandre Coelho
Santos, Pedro Paulo de Andrade
Camillo, Christina da Silva
Maciel, Bruna Leal Lima
Passos, Thaís Souza
format article
author Morais, Ana Heloneida de Araújo
Medeiros, Isaiane
Oliveira, Grazielle Louise Ribeiro de
Queiroz, Jaluza Luana Carvalho de
Gomes, Camila de Carvalho
Carvalho, Fabiana Maria Coimbra de
Lima, Maíra Conceição Jerônimo de Souza
Serquiz, Alexandre Coelho
Santos, Pedro Paulo de Andrade
Camillo, Christina da Silva
Maciel, Bruna Leal Lima
Passos, Thaís Souza
author_sort Morais, Ana Heloneida de Araújo
title Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation
title_short Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation
title_full Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation
title_fullStr Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation
title_full_unstemmed Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation
title_sort safety and bioactive potential of nanoparticles containing cantaloupe melon (cucumis melo l.) carotenoids in an experimental model of chronic inflammation
publisher Elsevier
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/54626
https://doi.org/10.1016/j.btre.2020.e00567
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