Efeitos comparativos da radiofrequência fracionada e do microagulhamento na vulva de mulheres na pós-menopausa: alterações histológicas e clínicas
The period of menopause brings different changes, such as vulvar flaccidity, which interferes with the female quality of life. Fractional radiofrequency and microneedling are non-invasive treatments that act on collagen fibers. The aim of this study was to evaluate the clinical and histological c...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/54338 |
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| Resumo: | The period of menopause brings different changes, such as vulvar flaccidity,
which interferes with the female quality of life. Fractional radiofrequency and
microneedling are non-invasive treatments that act on collagen fibers. The aim of
this study was to evaluate the clinical and histological changes induced by
Fractional Radiofrequency (RFF) and microneedling in vulvar tissue. Thirty
postmenopausal women were randomly divided into groups G1 (RFF) and G2
(microneedling). Subablative RFF was performed with disposable fractional
electrodes with an intensity of 8 mJ. Microneedling was performed with the derma
roller system. Pre- and post-treatment times were evaluated using the Vaginal
Laxity Questionnaire (VLQ), the EQ-5D questionnaire for quality of life, and the
Blatt and Kupperman Menopause Index (BKMI). Biopsies of the labia majora
were taken for histological and immunohistochemical analysis of the proposed
treatments. Data were expressed as mean (± standard deviation). A paired t-test
was used for intragroup comparison (pre- and post-treatment) and an
independent t-test used to compare intergroup data (pre- and post-treatment). In
the G1 group, the VLQ values showed differences from pre-treatment values with
data obtained 60 days after the beginning of sessions (p=0.01). Likewise, the
changes in the data from the G2 group were significant (p=0.001) in the same
time interval. In the comparison between the groups, the VLQ values were not
different (p>0.05). Regarding histological analysis, the RFF showed improvement
regarding the number of fibroblasts, blood vessels and fatty degeneration
(p<0.05) compared to the control. In addition, RFF and microneedling samples
showed higher expression of type III collagen and vimentin in
immunohistochemical analysis (p<0.05). The therapies proved to be effective in
treating flaccidity of the female external genitalia. Furthermore, histological
changes were observed after interventions suggesting collagen remodeling. |
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