Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study
Introduction: low 25-hydroxyvitamin D [25(OH)D] levels occur after kidney transplantation (KTx), and can be associated with increase the risk of graft loss. This longitudinal study aimed to evaluate the vitamin D status and association with biomarkers of the renal graft function after KTx. Methods:...
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ri-123456789-542942023-07-31T15:26:25Z Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study Estado de la vitamina D y biomarcadores de función del injerto renal después del trasplante de riñón: un estudio longitudinal Medeiros, Paulo José de Lima, Mabelle Alves Ferreira de Souza, Karla Simone Costa de Andrade, César Endrigo Silva de Ururahy, Marcela Abbott Galvão Almeida, José Bruno de Pereira, Maurício Galvão Evangelista, Karine Cavalcanti Maurício Sena Rezende, Adriana Augusto de kidney transplantation 25-Hydroxyvitamin D hypovitaminosis D albuminuria urinary albumin/creatinine ratio Introduction: low 25-hydroxyvitamin D [25(OH)D] levels occur after kidney transplantation (KTx), and can be associated with increase the risk of graft loss. This longitudinal study aimed to evaluate the vitamin D status and association with biomarkers of the renal graft function after KTx. Methods: this longitudinal study included 42 patients evaluated at baseline, 3 and 6 months after KTx. Biodemographic, clinical, and biochemical parameters such as 25(OH)D and parathyroid hormone (PTH), and biomarkers of renal graft function, such as creatinine, estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR), were assessed. Sun exposure was also evaluated. Patients were categorized according to their 25(OH)D levels. Results: at baseline, 25(OH)D levels < 30 ng/mL were found in 43 % patients, and 38 % of these patients failed to improve their 25(OH)D levels by 6 months after KTx. Low 25(OH)D levels occurred regardless of sun exposure. Further, 44 % patients developed albuminuria at 6 months. An increased ACR was observed in patients with 25(OH)D levels < 30 ng/mL (p = 0.002) compared to that in patients with 25(OH)D > 30 ng/ mL. Additionally, 25(OH)D levels were negatively correlated with ACR at 6 months post-KTx (r = -0.444; p = 0.003). Twelve (28.6 %) patients with 25(OH)D levels < 30 ng/mL showed no eGFR recovery until 6 months after KTx. Conclusion: low vitamin D levels and increased albuminuria were observed at 6 months after KTx, even in a region with high sun exposure. The association between vitamin D status and biomarkers of renal graft function after KTx should be explored in further studies. 2023-07-31T15:26:24Z 2023-07-31T15:26:24Z 2023 article REZENDE, Adriana Augusto de; LIMA, Mabelle Alves Ferreira de; SOUZA, Karla Simone Costa de; ANDRADE, César Endrigo Silva de; URURAHY, Marcela Abbott Galvão; MEDEIROS, Paulo José de; PEREIRA, Maurício Galvão; ALMEIDA, José Bruno de; EVANGELISTA, Karine Cavalcanti Maurício Sena. Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study. Nutrición Hospitalaria, [S.L.], p. 1, 2023. ARAN Ediciones. http://dx.doi.org/10.20960/nh.04024. Disponível em: https://www.nutricionhospitalaria.org/articles/04024/show. Acesso em: 11 jul. 2023. https://repositorio.ufrn.br/handle/123456789/54294 http://dx.doi.org/10.20960/nh.04024 en Attribution-NonCommercial-ShareAlike 3.0 Brazil http://creativecommons.org/licenses/by-nc-sa/3.0/br/ application/pdf Nutrición Hospitalaria |
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kidney transplantation 25-Hydroxyvitamin D hypovitaminosis D albuminuria urinary albumin/creatinine ratio |
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kidney transplantation 25-Hydroxyvitamin D hypovitaminosis D albuminuria urinary albumin/creatinine ratio Medeiros, Paulo José de Lima, Mabelle Alves Ferreira de Souza, Karla Simone Costa de Andrade, César Endrigo Silva de Ururahy, Marcela Abbott Galvão Almeida, José Bruno de Pereira, Maurício Galvão Evangelista, Karine Cavalcanti Maurício Sena Rezende, Adriana Augusto de Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
| description |
Introduction: low 25-hydroxyvitamin D [25(OH)D] levels occur after kidney transplantation (KTx), and can be associated with increase the risk of graft loss. This longitudinal study aimed to evaluate the vitamin D status and association with biomarkers of the renal graft function after KTx. Methods: this longitudinal study included 42 patients evaluated at baseline, 3 and 6 months after KTx. Biodemographic, clinical, and biochemical
parameters such as 25(OH)D and parathyroid hormone (PTH), and biomarkers of renal graft function, such as creatinine, estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR), were assessed. Sun exposure was also evaluated. Patients were categorized according to their 25(OH)D levels.
Results: at baseline, 25(OH)D levels < 30 ng/mL were found in 43 % patients, and 38 % of these patients failed to improve their 25(OH)D levels by 6 months after KTx. Low 25(OH)D levels occurred regardless of sun exposure. Further, 44 % patients developed albuminuria at 6 months. An increased ACR was observed in patients with 25(OH)D levels < 30 ng/mL (p = 0.002) compared to that in patients with 25(OH)D > 30 ng/
mL. Additionally, 25(OH)D levels were negatively correlated with ACR at 6 months post-KTx (r = -0.444; p = 0.003). Twelve (28.6 %) patients with 25(OH)D levels < 30 ng/mL showed no eGFR recovery until 6 months after KTx. Conclusion: low vitamin D levels and increased albuminuria were observed at 6 months after KTx, even in a region with high sun exposure. The association between vitamin D status and biomarkers of renal graft function after KTx should be explored in further studies. |
| format |
article |
| author |
Medeiros, Paulo José de Lima, Mabelle Alves Ferreira de Souza, Karla Simone Costa de Andrade, César Endrigo Silva de Ururahy, Marcela Abbott Galvão Almeida, José Bruno de Pereira, Maurício Galvão Evangelista, Karine Cavalcanti Maurício Sena Rezende, Adriana Augusto de |
| author_facet |
Medeiros, Paulo José de Lima, Mabelle Alves Ferreira de Souza, Karla Simone Costa de Andrade, César Endrigo Silva de Ururahy, Marcela Abbott Galvão Almeida, José Bruno de Pereira, Maurício Galvão Evangelista, Karine Cavalcanti Maurício Sena Rezende, Adriana Augusto de |
| author_sort |
Medeiros, Paulo José de |
| title |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
| title_short |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
| title_full |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
| title_fullStr |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
| title_full_unstemmed |
Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
| title_sort |
vitamin d status and biomarkers of renal graft function after kidney transplantation: a longitudinal study |
| publisher |
Nutrición Hospitalaria |
| publishDate |
2023 |
| url |
https://repositorio.ufrn.br/handle/123456789/54294 http://dx.doi.org/10.20960/nh.04024 |
| work_keys_str_mv |
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