Os efeitos terapêuticos da família anacardiaceae na diabetes mellitus experimental: uma revisão de escopo
Introduction: Diabetes mellitus (DM) is a heterogeneous metabolic disease that affects a large part of the world's population. It has a variable origin but is mainly characterized by changes in the plasma glucose rate due to an autoimmune body response, leading to the degeneration of pancreatic...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/53908 |
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| Resumo: | Introduction: Diabetes mellitus (DM) is a heterogeneous metabolic disease that affects a large part of the world's population. It has a variable origin but is mainly characterized by changes in the plasma glucose rate due to an autoimmune body response, leading to the degeneration of pancreatic beta cells, thus characterizing type 1 diabetes mellitus. Alternatively, it can be caused by the reduced responsiveness of pancreatic beta cell receptors to the hormone insulin, resulting in type 2 diabetes mellitus. The demand for therapy options for this disease is continuously increasing. Objectives: To conduct a qualitative investigation into the potential therapeutic and pharmacological effects of plant species belonging to the Anacardiaceae family in experimental diabetes mellitus. Eligibility criteria: Studies conducted with rodents (in vivo and ex vivo) using species from the Anacardiaceae family as an alternative treatment in an experimental model of diabetes mellitus were included. Studies involving invertebrate animals, birds, amphibians, reptiles, fish, and non-rodent mammals were excluded. Additionally, studies that did not simultaneously involve the Anacardiaceae family and experimental diabetes mellitus, or studies that solely utilized synthetic drugs available on the market as treatment without any association with the natural product in question, were also excluded. Methodology: This scoping review was conducted by employing suitable combinations and word truncations that were specifically selected and adapted for each electronic database, namely PubMed/MEDLINE, Scopus, Web of Science, and EMBASE. In addition, a supplementary bibliographic search was conducted using Google Scholar and ProQuest, with no restrictions on language or publication date. Results: Out of the total of 45 articles evaluated, it was observed that the year 2004 marked the first instance of a relationship between the Anacardiaceae family and experimental Diabetes Mellitus. Within the last 10 years, 33% of these articles were published. Among the articles, 74% utilized Wistar rats as the primary experimental model, with a preference for male subjects. Streptozotocin was the chosen method for inducing experimental Diabetes Mellitus in 60% of the studies. Several species, including Anacardium occidentale (cashew), Semecarpus anacardium (cashew), and Mangifera indica (mango), were predominant in the studies. Additionally, 76% of the evaluated articles demonstrated that natural extracts derived from plant species belonging to the Anacardiaceae family exhibited antihyperglycemic activity. Histological evaluations were performed in 42% of the articles, while 89% of them conducted biochemical research. Conclusion: The Anacardiaceae family encompasses several plant species with medicinal characteristics, such as anti-hyperglycemic properties, demonstrated in 76% of the extracts from the species evaluated in this review. This highlights their tremendous potential as an alternative, cost-effective, and easily accessible therapy in the treatment of experimental Diabetes Mellitus due to their natural origin. Consequently, this review summarizes the therapeutic effects provided by plant species belonging to the Anacardiaceae family, classifying it as a significant source for phytotherapy. |
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