Análise morfológica do tecido pulmonar de animais submetidos a oxigenoterapia hiperbárica
Introduction: Hyperbaric Oxygen Therapy is a medical application characterized by the intermittent inhalation of 100% oxygen under an atmospheric pressure greater than 1 ATM. This elevated partial pressure of oxygen when inspired causes an increase in plasma dissolved oxygen levels. The use of hyper...
Na minha lista:
| Autor principal: | |
|---|---|
| Outros Autores: | |
| Formato: | bachelorThesis |
| Idioma: | pt_BR |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
|
| Assuntos: | |
| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/53897 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
| Resumo: | Introduction: Hyperbaric Oxygen Therapy is a medical application characterized by the intermittent inhalation of 100% oxygen under an atmospheric pressure greater than 1 ATM. This elevated partial pressure of oxygen when inspired causes an increase in plasma dissolved oxygen levels. The use of hyperbaric oxygen currently has 14 indications in different clinical contexts, severe anemia, burn injury, decompression illness, among others. Objective: To evaluate the morphological alterations of the lung tissue of normal Wistar rats submitted to Hyperbaric Oxygen Therapy (HBO). Methodology: 24 Wistar rats were used, manipulated and submitted to hyperbaric oxygen therapy, being divided into two groups: 1) CT - Control group and 2) HBOT - Group submitted to hyperbaric chamber. After seven days of adaptation in the off-chamber, HBOT was performed daily for two weeks. The parameters analyzed in this present study included feed intake, water intake, weight gain and blood glucose, morphological variables such as congestion, inflammation and thickness and morphometric tools of the lung parenchyma: Fraction of the respiratory area and thickness of the septa. Results: Mean feed intake significantly decreased in the group submitted to HBOT, being the only preclinical parameter with significant changes between the two groups. As for the morphological aspect, an increase in congested vessels and inflammatory focus was observed in the captures of the HBOT group. With the use of morphometry tools and observing only the two chosen parameters, there were no significant differences between the two groups. Conclusion: The use of hyperbaric oxygen in healthy rats did not cause significant morphological changes in the lung parenchyma. Thus, there was no interference in the morphology of the respiratory system in the experimental model, which reinforces that HBOT is a safe method for the treatment of other diseases involving the respiratory system. |
|---|