O risco do uso inadequado das plantas medicinais
Phytotherapy is widely used worldwide, especially in Brazil, which has a rich botanical and cultural diversity. However, it is important to recognize that phytotherapeutic products are medicines and not food. Often, proponents of phytotherapy propagate the idea that it is natural, free from toxins a...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/53549 |
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| Resumo: | Phytotherapy is widely used worldwide, especially in Brazil, which has a rich botanical and cultural diversity. However, it is important to recognize that phytotherapeutic products are medicines and not food. Often, proponents of phytotherapy propagate the idea that it is natural, free from toxins and adverse effects, and can be used in the long term. However, this can lead to serious adverse events due to the improper use of medicinal plants. This study aims to investigate the risks associated with the improper use of medicinal plants and highlight the importance of informed and responsible practice. The adopted methodology is exploratory with a bibliographic procedure. The literature review was narrative in nature. Books on the subject were consulted, and a search was conducted in the SciELO and BVS databases. Phytotherapeutic medicines are often used concurrently with conventional drugs, making potential pharmacokinetic interactions a cause for concern. The coadministration of phytotherapeutic medicines with drugs with narrow therapeutic indices raises even deeper safety concerns. Therefore, knowledge of the potential of phytotherapeutics to inhibit and/or induce the expression of key drug-metabolizing enzymes is of utmost importance for safety in these situations. The severity of drug-induced liver injury (DILI) ranges from mild dysfunction to jaundice and evident liver failure, which can culminate in liver transplantation or death. Long-term carcinogenicity studies have rarely been conducted with phytotherapeutic products. The notion that herbal medicines require less rigorous and comprehensive safety and efficacy evaluation is questionable. The fact that several hepatotoxic or potentially carcinogenic plants have long been used in traditional medicine also demonstrates that traditional use alone does not guarantee the safety of a phytotherapeutic product. In general, it can be concluded that a regulatory framework for medicinal plants can provide greater assurance to consumers. Additionally, clinical monitoring, spontaneous reporting systems, or active pharmacovigilance are necessary to identify safety issues from a therapeutic perspective. |
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