Produção de fitas cerâmicas via tape casting para aplicação biomédica
To overcome the shortcomings existing in conventional dosage forms, the targeted drug delivery system was created. The aim was to deliver drugs to site-specific with a reduced dosing frequency and to mitigate the side effects caused by conventional drug delivery systems. Nanoparticles have been u...
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| Formato: | doctoralThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/53344 |
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| Resumo: | To overcome the shortcomings existing in conventional dosage forms, the targeted drug
delivery system was created. The aim was to deliver drugs to site-specific with a reduced
dosing frequency and to mitigate the side effects caused by conventional drug delivery
systems. Nanoparticles have been used as carriers of these drugs, including mesoporous
silica nanoparticles, carbon nanotubes, and polymeric nanoparticles. In addition, the use
of different techniques to produce these systems, such as the tape casting method, is
responsible for producing thin films, and flexible ceramic tapes with good surface quality
and low cost. In this work, studies were carried out regarding the production of ceramic
tapes through the tape casting method, obtaining materials to be used in the biomedical
area. Tricalcium phosphate ceramic tapes with different percentages of chitosan were
produced. Another composition studied was the clay mineral palygorskite, using
neomycin to study drug release. The first step was to study the powders, with X-ray
diffraction analysis (XRD), thermogravimetric analysis (TGA), and scanning electron
microscopy (SEM). The slips were identified through the rheological test and then the
ceramic tape was tape casting. These were characterized through X-ray diffraction
analysis (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry
(DSC), Fourier-transform infrared spectroscopy (FTIR), elemental analysis (CHN-S),
and scanning electron microscopy (SEM). In addition to these, antimicrobial activity tests
were carried out, as well as absorption energy calculations. According to the results
obtained, the pseudoplastic behavior of the suspension was observed, as suitable for the
conformation of ceramic tapes. Reflection peaks referring to the palygorskite phase, with
an orthorhombic structure, and the tricalcium phosphate phase, with an orthorhombic
structure, were detected. DSC analysis identified exothermic peaks characteristic of
neomycin. Therefore, thin films and flexible, biodegradable, biocompatible ceramic tapes
were produced, which presented important characteristics for use in the biomedical area. |
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