Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets

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Chronic low-grade inflammation is present in overweight and obesity, causing changes in several metabolic pathways. It impairs systemic functioning and positively feeds back the accumula tion of more adipose tissue. Studies with hydrolyzed proteins and plant peptides have demonstrated a potential an...

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Principais autores: Morais, Ana Heloneida de Araújo, Medeiros, Amanda Fernandes de, Queiroz, Jaluza Luana Carvalho de, Maciel, Bruna Leal Lima
Outros Autores: http://lattes.cnpq.br/1233944493334651
Formato: article
Idioma:English
Publicado em: Nutrients
Assuntos:
amino acids
peptides and proteins
anti-inflammatory agents
anti-obesity agents
inflammation mediators
Endereço do item:https://repositorio.ufrn.br/handle/123456789/53246
https://doi.org/10.3390/nu14030690
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spelling ri-123456789-532462023-07-11T21:15:55Z Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets Morais, Ana Heloneida de Araújo Medeiros, Amanda Fernandes de Queiroz, Jaluza Luana Carvalho de Maciel, Bruna Leal Lima http://lattes.cnpq.br/1233944493334651 amino acids peptides and proteins anti-inflammatory agents anti-obesity agents inflammation mediators Chronic low-grade inflammation is present in overweight and obesity, causing changes in several metabolic pathways. It impairs systemic functioning and positively feeds back the accumula tion of more adipose tissue. Studies with hydrolyzed proteins and plant peptides have demonstrated a potential anti-inflammatory and immunomodulatory effect of these peptides. However, it is chal lenging and necessary to explore the mechanism of action of such molecules because understanding their effects depends on their structural characterizations. Furthermore, the structure might also give insights into safety, efficacy and efficiency, with a view of a possible health application. Thus, the present narrative review aimed to discuss the mechanisms of action of hydrolyzed proteins and plant peptides as anti-inflammatory agents in obesity. Keywords and related terms were inserted into databases for the search. Based on the studies evaluated, these biomolecules act by different pathways, favoring the reduction of inflammatory cytokines and adipokines and the polarization of macrophages to the M2 phenotype. Finally, as a future perspective, bioinformatics is suggested as a tool to help understand and better use these molecules considering their applicability in pre-clinical and clinical studies 2023-07-11T21:15:54Z 2023-07-11T21:15:54Z 2022 article MEDEIROS, Amanda Fernandes de et al. Hydrolyzed proteins and vegetable Peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets. Nutrients, v. 14, n. 3, p. 690, 2022. https://repositorio.ufrn.br/handle/123456789/53246 https://doi.org/10.3390/nu14030690 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Nutrients
institution Repositório Institucional
collection RI - UFRN
language English
topic amino acids
peptides and proteins
anti-inflammatory agents
anti-obesity agents
inflammation mediators
spellingShingle amino acids
peptides and proteins
anti-inflammatory agents
anti-obesity agents
inflammation mediators
Morais, Ana Heloneida de Araújo
Medeiros, Amanda Fernandes de
Queiroz, Jaluza Luana Carvalho de
Maciel, Bruna Leal Lima
Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
description Chronic low-grade inflammation is present in overweight and obesity, causing changes in several metabolic pathways. It impairs systemic functioning and positively feeds back the accumula tion of more adipose tissue. Studies with hydrolyzed proteins and plant peptides have demonstrated a potential anti-inflammatory and immunomodulatory effect of these peptides. However, it is chal lenging and necessary to explore the mechanism of action of such molecules because understanding their effects depends on their structural characterizations. Furthermore, the structure might also give insights into safety, efficacy and efficiency, with a view of a possible health application. Thus, the present narrative review aimed to discuss the mechanisms of action of hydrolyzed proteins and plant peptides as anti-inflammatory agents in obesity. Keywords and related terms were inserted into databases for the search. Based on the studies evaluated, these biomolecules act by different pathways, favoring the reduction of inflammatory cytokines and adipokines and the polarization of macrophages to the M2 phenotype. Finally, as a future perspective, bioinformatics is suggested as a tool to help understand and better use these molecules considering their applicability in pre-clinical and clinical studies
author2 http://lattes.cnpq.br/1233944493334651
author_facet http://lattes.cnpq.br/1233944493334651
Morais, Ana Heloneida de Araújo
Medeiros, Amanda Fernandes de
Queiroz, Jaluza Luana Carvalho de
Maciel, Bruna Leal Lima
format article
author Morais, Ana Heloneida de Araújo
Medeiros, Amanda Fernandes de
Queiroz, Jaluza Luana Carvalho de
Maciel, Bruna Leal Lima
author_sort Morais, Ana Heloneida de Araújo
title Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
title_short Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
title_full Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
title_fullStr Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
title_full_unstemmed Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
title_sort hydrolyzed proteins and vegetable peptides: anti-inflammatory mechanisms in obesity and potential therapeutic targets
publisher Nutrients
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/53246
https://doi.org/10.3390/nu14030690
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AT medeirosamandafernandesde hydrolyzedproteinsandvegetablepeptidesantiinflammatorymechanismsinobesityandpotentialtherapeutictargets
AT queirozjaluzaluanacarvalhode hydrolyzedproteinsandvegetablepeptidesantiinflammatorymechanismsinobesityandpotentialtherapeutictargets
AT macielbrunaleallima hydrolyzedproteinsandvegetablepeptidesantiinflammatorymechanismsinobesityandpotentialtherapeutictargets
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