Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features
AIM To investigate the association between 16 insertion-deletions (INDEL) polymorphisms, colorectal cancer (CRC) risk and clinical features in an admixed population. Methodos: One hundred and forty patients with CRC and 140 cancer-free subjects were examined. Genomic DNA was extracted from periphera...
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World Journal Of Gastroenterology
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ri-123456789-531022023-07-06T18:19:51Z Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features Correa, Romualdo da Silva Marques, Diego Costa, Layse Raynara Ferreira Costa, Lorenna Larissa Ferreira Borges, Aline Maciel Pinheiro Ito, Fernanda Ribeiro Ramos, Carlos Cesar de Oliveira Bortolin, Raul Hernandes Luchessi, André Ducati Santos, Ândrea Ribeiro dos Santos, Sidney Silbiger, Vivian Nogueira colorectal cancer ins-del polymorphism admixed population potential biomarker diagnostic risk stratification prognostic clinical features AIM To investigate the association between 16 insertion-deletions (INDEL) polymorphisms, colorectal cancer (CRC) risk and clinical features in an admixed population. Methodos: One hundred and forty patients with CRC and 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on GeneMapper ID v3.2. Clinicopathological data were obtained by consulting the patients’ clinical charts, intra-operative documentation, and pathology scoring. Rerults: Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis (TNM) stage risk, the Ins alleles of ACE, HLAG and TP53 (6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death risk. Conclusion: The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings. 2023-07-06T18:19:33Z 2023-07-06T18:19:33Z 2017-10-07 article CORREA, Romualdo da Silva; MARQUES, Diego; FERREIRA-COSTA, Layse Raynara; FERREIRA-COSTA, Lorenna Larissa; BORGES, Aline Maciel Pinheiro; ITO, Fernanda Ribeiro; RAMOS, Carlos Cesar de Oliveira; BORTOLIN, Raul Hernandes; LUCHESSI, André Ducati; RIBEIRO-DOS-SANTOS, Ândrea. Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features. World Journal Of Gastroenterology, [S.L.], v. 23, n. 37, p. 6854-6867, 7 out. 2017. Baishideng Publishing Group Inc.. http://dx.doi.org/10.3748/wjg.v23.i37.6854. Disponível em: https://www.wjgnet.com/1007-9327/full/v23/i37/6854.htm. Acesso em: 05 jul. 2023. https://repositorio.ufrn.br/handle/123456789/53102 https://dx.doi.org/10.3748/wjg.v23.i37.6854 en Attribution-NonCommercial-NoDerivs 3.0 Brazil Attribution-NonCommercial 3.0 Brazil http://creativecommons.org/licenses/by-nc/3.0/br/ application/pdf World Journal Of Gastroenterology |
| institution |
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| collection |
RI - UFRN |
| language |
English |
| topic |
colorectal cancer ins-del polymorphism admixed population potential biomarker diagnostic risk stratification prognostic clinical features |
| spellingShingle |
colorectal cancer ins-del polymorphism admixed population potential biomarker diagnostic risk stratification prognostic clinical features Correa, Romualdo da Silva Marques, Diego Costa, Layse Raynara Ferreira Costa, Lorenna Larissa Ferreira Borges, Aline Maciel Pinheiro Ito, Fernanda Ribeiro Ramos, Carlos Cesar de Oliveira Bortolin, Raul Hernandes Luchessi, André Ducati Santos, Ândrea Ribeiro dos Santos, Sidney Silbiger, Vivian Nogueira Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features |
| description |
AIM To investigate the association between 16 insertion-deletions (INDEL) polymorphisms, colorectal cancer (CRC) risk and clinical features in an admixed population. Methodos: One hundred and forty patients with CRC and 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on GeneMapper ID v3.2. Clinicopathological data were obtained by consulting the patients’ clinical charts, intra-operative documentation, and pathology scoring. Rerults: Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis (TNM) stage risk, the Ins alleles of ACE, HLAG and TP53 (6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death risk.
Conclusion: The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings. |
| format |
article |
| author |
Correa, Romualdo da Silva Marques, Diego Costa, Layse Raynara Ferreira Costa, Lorenna Larissa Ferreira Borges, Aline Maciel Pinheiro Ito, Fernanda Ribeiro Ramos, Carlos Cesar de Oliveira Bortolin, Raul Hernandes Luchessi, André Ducati Santos, Ândrea Ribeiro dos Santos, Sidney Silbiger, Vivian Nogueira |
| author_facet |
Correa, Romualdo da Silva Marques, Diego Costa, Layse Raynara Ferreira Costa, Lorenna Larissa Ferreira Borges, Aline Maciel Pinheiro Ito, Fernanda Ribeiro Ramos, Carlos Cesar de Oliveira Bortolin, Raul Hernandes Luchessi, André Ducati Santos, Ândrea Ribeiro dos Santos, Sidney Silbiger, Vivian Nogueira |
| author_sort |
Correa, Romualdo da Silva |
| title |
Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features |
| title_short |
Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features |
| title_full |
Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features |
| title_fullStr |
Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features |
| title_full_unstemmed |
Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features |
| title_sort |
association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features |
| publisher |
World Journal Of Gastroenterology |
| publishDate |
2023 |
| url |
https://repositorio.ufrn.br/handle/123456789/53102 https://dx.doi.org/10.3748/wjg.v23.i37.6854 |
| work_keys_str_mv |
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| _version_ |
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