Derivados prenilados e geranilados de acilfloroglucinois monoméricos de origem natural: ocorrência, propriedades biológicas e dados espectroscópicos
Derivatives of acylated monomeric phloroglucinols are predominant secondary metabolites in the genus Hypericum and have an acyl group directly connected to the THB core (1,3,5- trihydroxy-benzene), in addition to very commonly also having prenyl and geranyl substituents. The origin of these compo...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/52602 |
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| Resumo: | Derivatives of acylated monomeric phloroglucinols are predominant secondary metabolites in
the genus Hypericum and have an acyl group directly connected to the THB core (1,3,5-
trihydroxy-benzene), in addition to very commonly also having prenyl and geranyl substituents.
The origin of these compounds shows that the carbonyl unit is bioenergetically favored, this is
because phloroglucinols come from a biosynthetic route where the THB core is biosynthesized
via the acetate-malonate pathway, being susceptible to cyclization and oxidation. Due to its
structural variability associated with diverse biological activities and the presence of
unprecedented phloroglucinois in Harpalyce brasiliana isolated by our research group, the
interest in carrying out this review arose, aiming to explore the theme more specifically. For
this, data from the period between 1965 at 2022 were collected on the Google Scholar,
Periodicals CAPES, Science Direct and ScienceFinder platforms, considering as inclusion
criteria compounds from the class of monomeric acylfloroglucinols, also known as
acetophenones, from the mentioned biosynthesis, that occurs in different species of plants,
being isolated from their extracts and cataloged structurally and biologically. Among the main
biological activities found, the following stand out: anti-inflammatory, antibacterial and
cytotoxic. 1H and 13C NMR (nuclear magnetic resonance) data served as a basis for the chemical
analysis of the compounds and their grouping into monocyclic and polycyclic monomeric
classes with prenyl and geranyl substitutions. |
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