Obtenção de micropartículas polímericas para veiculação de α, β-amirina: caracterização físico-química e avaliação de atividades biológicas in vitro
Triterpenoids have aroused the interest of the scientific community in recent years due to the use, in popular medicine, of natural complexes that contain these substances in their composition. Among them, there is α, β-amyrin, a pentacyclic triterpene that consists of an isomeric mixture of comp...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/52591 |
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| Resumo: | Triterpenoids have aroused the interest of the scientific community in recent
years due to the use, in popular medicine, of natural complexes that contain
these substances in their composition. Among them, there is α, β-amyrin, a
pentacyclic triterpene that consists of an isomeric mixture of compounds with
ursane and oleonane backbone. Some pharmacological activities have been
reported, however, with no defined pharmacodynamic target. In addition, the
low solubility in water hinders the absorption of the compound. In this work,
polymeric microparticles with hydropropylmethylcellulose (HPMC) were
developed to carry α, β-amyrin and the biological activity of inhibitor of α-
glucosidase and pancreatic lipase, agonist of Liver X Receptor β (LXRβ) and
antioxidant capacity was investigated. In addition, the physical-chemical
characterization of the obtained systems was carried out. In it, the spectra
obtained in the FTIR showed effective interaction between the active principle
and the polymer; in the DR-X diffractograms, it was observed that the isolated
active presents high crystallinity, but, when incorporated into the polymeric
microparticles, this crystallinity reduced; Scanning Electron Microscopy (SEM),
as well as DR-X, showed α, β-amyrin as a highly crystalline structure, with welldefined,
long, needle-shaped crystals. When carried in the microparticles, the
crystals, although still visible, were considerably reduced in size. The results of
the lipase and α-glucosidase inhibition assay showed that the microparticles did
not inhibit such enzymes, however, the agonist activity of the nuclear receptor
LXRβ showed that the active ingredient exerts agonist activity on this receptor.
More studies seeking to elucidate the targets through which α, β-amyrin exerts
its effects must be carried out and other studies delving into its effect on the LXRβ receptor. |
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