Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets

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Chronic low-grade inflammation is present in overweight and obesity, causing changes in several metabolic pathways. It impairs systemic functioning and positively feeds back the accumula tion of more adipose tissue. Studies with hydrolyzed proteins and plant peptides have demonstrated a potential an...

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Principais autores: Medeiros, Amanda Fernandes de, Queiroz, Jaluza Luana Carvalho de, Maciel, Bruna Leal Lima, Morais, Ana Heloneida de Araújo
Outros Autores: https://orcid.org/0000-0002-6460-911X
Formato: article
Idioma:English
Publicado em: Nutrients
Assuntos:
aminoacids
peptides and proteins
anti-obesity agents
anti-inflammatory agents
inflammation mediators
Endereço do item:https://repositorio.ufrn.br/handle/123456789/52530
https://doi.org/10.3390/nu14030690
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spelling ri-123456789-525302023-05-25T20:34:40Z Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets Medeiros, Amanda Fernandes de Queiroz, Jaluza Luana Carvalho de Maciel, Bruna Leal Lima Morais, Ana Heloneida de Araújo https://orcid.org/0000-0002-6460-911X aminoacids peptides and proteins anti-obesity agents anti-inflammatory agents inflammation mediators Chronic low-grade inflammation is present in overweight and obesity, causing changes in several metabolic pathways. It impairs systemic functioning and positively feeds back the accumula tion of more adipose tissue. Studies with hydrolyzed proteins and plant peptides have demonstrated a potential anti-inflammatory and immunomodulatory effect of these peptides. However, it is chal lenging and necessary to explore the mechanism of action of such molecules because understanding their effects depends on their structural characterizations. Furthermore, the structure might also give insights into safety, efficacy and efficiency, with a view of a possible health application. Thus, the present narrative review aimed to discuss the mechanisms of action of hydrolyzed proteins and plant peptides as anti-inflammatory agents in obesity. Keywords and related terms were inserted into databases for the search. Based on the studies evaluated, these biomolecules act by different pathways, favoring the reduction of inflammatory cytokines and adipokines and the polarization of macrophages to the M2 phenotype. Finally, as a future perspective, bioinformatics is suggested as a tool to help understand and better use these molecules considering their applicability in pre-clinical and clinical studies. 2023-05-25T20:34:40Z 2023-05-25T20:34:40Z 2022 article MEDEIROS, Amanda Fernandes de et al. Hydrolyzed proteins and vegetable peptides: anti-Inflammatory Mechanisms in obesity and potential therapeutic targets. Nutrients, v. 14, n. 3, p. 690, 2022. https://repositorio.ufrn.br/handle/123456789/52530 https://doi.org/10.3390/nu14030690 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Nutrients
institution Repositório Institucional
collection RI - UFRN
language English
topic aminoacids
peptides and proteins
anti-obesity agents
anti-inflammatory agents
inflammation mediators
spellingShingle aminoacids
peptides and proteins
anti-obesity agents
anti-inflammatory agents
inflammation mediators
Medeiros, Amanda Fernandes de
Queiroz, Jaluza Luana Carvalho de
Maciel, Bruna Leal Lima
Morais, Ana Heloneida de Araújo
Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
description Chronic low-grade inflammation is present in overweight and obesity, causing changes in several metabolic pathways. It impairs systemic functioning and positively feeds back the accumula tion of more adipose tissue. Studies with hydrolyzed proteins and plant peptides have demonstrated a potential anti-inflammatory and immunomodulatory effect of these peptides. However, it is chal lenging and necessary to explore the mechanism of action of such molecules because understanding their effects depends on their structural characterizations. Furthermore, the structure might also give insights into safety, efficacy and efficiency, with a view of a possible health application. Thus, the present narrative review aimed to discuss the mechanisms of action of hydrolyzed proteins and plant peptides as anti-inflammatory agents in obesity. Keywords and related terms were inserted into databases for the search. Based on the studies evaluated, these biomolecules act by different pathways, favoring the reduction of inflammatory cytokines and adipokines and the polarization of macrophages to the M2 phenotype. Finally, as a future perspective, bioinformatics is suggested as a tool to help understand and better use these molecules considering their applicability in pre-clinical and clinical studies.
author2 https://orcid.org/0000-0002-6460-911X
author_facet https://orcid.org/0000-0002-6460-911X
Medeiros, Amanda Fernandes de
Queiroz, Jaluza Luana Carvalho de
Maciel, Bruna Leal Lima
Morais, Ana Heloneida de Araújo
format article
author Medeiros, Amanda Fernandes de
Queiroz, Jaluza Luana Carvalho de
Maciel, Bruna Leal Lima
Morais, Ana Heloneida de Araújo
author_sort Medeiros, Amanda Fernandes de
title Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
title_short Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
title_full Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
title_fullStr Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
title_full_unstemmed Hydrolyzed proteins and vegetable peptides: anti-Inflammatory mechanisms in obesity and potential therapeutic targets
title_sort hydrolyzed proteins and vegetable peptides: anti-inflammatory mechanisms in obesity and potential therapeutic targets
publisher Nutrients
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/52530
https://doi.org/10.3390/nu14030690
work_keys_str_mv AT medeirosamandafernandesde hydrolyzedproteinsandvegetablepeptidesantiinflammatorymechanismsinobesityandpotentialtherapeutictargets
AT queirozjaluzaluanacarvalhode hydrolyzedproteinsandvegetablepeptidesantiinflammatorymechanismsinobesityandpotentialtherapeutictargets
AT macielbrunaleallima hydrolyzedproteinsandvegetablepeptidesantiinflammatorymechanismsinobesityandpotentialtherapeutictargets
AT moraisanaheloneidadearaujo hydrolyzedproteinsandvegetablepeptidesantiinflammatorymechanismsinobesityandpotentialtherapeutictargets
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