In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus a protocol for systematic review and meta analysis
Background: In silico studies using dynamic simulation or molecular docking have boosted the screening and identification of molecules and/or targets in studies aimed at treating diseases such as obesity and diabetes mellitus, optimizing the development of new drugs. This study aims to describe a s...
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ri-123456789-524922023-11-06T17:39:57Z In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus a protocol for systematic review and meta analysis Medeiros, Isaiane Aguiar, Ana Júlia Felipe Camelo Fortunato, Wendjilla Medeiros Teixeira, Ana Francisca Gomes Silva, Emilly Guedes Oliveira e Bezerra, Ingrid Wilza Leal Maia, Juliana Kelly da Silva Piuvezam, Grasiela Morais, Ana Heloneida de Araújo diabetes molecular docking simulation overweight peptides protein systematic review Background: In silico studies using dynamic simulation or molecular docking have boosted the screening and identification of molecules and/or targets in studies aimed at treating diseases such as obesity and diabetes mellitus, optimizing the development of new drugs. This study aims to describe a systematic review protocol on peptides and proteins evaluated in silico as potential therapeutic agents for obesity or diabetes mellitus. Methods: This protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols and was registered in the International Prospective Register of Systematic Reviews database (number: CRD42022355540). The databases to be searched will be PubMed, ScienceDirect, Scopus, Web of Science, virtual health library, and EMBASE. It will be included in silico studies that evaluate the simulation by dynamics or molecular docking of proteins or peptides involved in treating obesity or diabetes mellitus. Two independent reviewers will select studies, extract data, and assess methodological quality using the adapted Strengthening the reporting of empirical simulation studies. A narrative synthesis of the included studies will be performed for the systematic reviews. Results: This protocol contemplates the production of 2 systematic reviews to be developed focusing on obesity or diabetes mellitus. Conclusion: The reviews will enable knowledge of peptides and proteins involved in research treating these diseases and will emphasize the importance of in silico studies in this context and for the development of future studies 2023-05-19T21:35:10Z 2023-05-19T21:35:10Z 2023 article MEDEIROS, Isaiane et al. In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus: A protocol for systematic review and meta analysis. Medicine, v. 102, n. 15, 2023. Disponível em: https://journals.lww.com/md-journal/fulltext/2023/04140/in_silico_structure_based_design_of_peptides_or.1.aspx. Acesso em: 18 de mai. de 2023 1536-5964 https://repositorio.ufrn.br/handle/123456789/52492 en application/pdf Medicine |
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diabetes molecular docking simulation overweight peptides protein systematic review |
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diabetes molecular docking simulation overweight peptides protein systematic review Medeiros, Isaiane Aguiar, Ana Júlia Felipe Camelo Fortunato, Wendjilla Medeiros Teixeira, Ana Francisca Gomes Silva, Emilly Guedes Oliveira e Bezerra, Ingrid Wilza Leal Maia, Juliana Kelly da Silva Piuvezam, Grasiela Morais, Ana Heloneida de Araújo In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus a protocol for systematic review and meta analysis |
| description |
Background: In silico studies using dynamic simulation or molecular docking have boosted the screening and identification of molecules and/or targets in studies aimed at treating diseases such as obesity and diabetes mellitus, optimizing the development of new drugs. This study aims to describe a systematic review protocol on peptides and proteins evaluated in silico as potential therapeutic agents for obesity or diabetes mellitus.
Methods: This protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols and was registered in the International Prospective Register of Systematic Reviews database (number: CRD42022355540). The databases to be searched will be PubMed, ScienceDirect, Scopus, Web of Science, virtual health library, and EMBASE. It will be included in silico studies that evaluate the simulation by dynamics or molecular docking of proteins or peptides involved in treating obesity or diabetes mellitus. Two independent reviewers will select studies, extract data, and assess methodological quality using the
adapted Strengthening the reporting of empirical simulation studies. A narrative synthesis of the included studies will be performed for the systematic reviews. Results: This protocol contemplates the production of 2 systematic reviews to be developed focusing on obesity or diabetes mellitus. Conclusion: The reviews will enable knowledge of peptides and proteins involved in research treating these diseases and will emphasize the importance of in silico studies in this context and for the development of future studies |
| format |
article |
| author |
Medeiros, Isaiane Aguiar, Ana Júlia Felipe Camelo Fortunato, Wendjilla Medeiros Teixeira, Ana Francisca Gomes Silva, Emilly Guedes Oliveira e Bezerra, Ingrid Wilza Leal Maia, Juliana Kelly da Silva Piuvezam, Grasiela Morais, Ana Heloneida de Araújo |
| author_facet |
Medeiros, Isaiane Aguiar, Ana Júlia Felipe Camelo Fortunato, Wendjilla Medeiros Teixeira, Ana Francisca Gomes Silva, Emilly Guedes Oliveira e Bezerra, Ingrid Wilza Leal Maia, Juliana Kelly da Silva Piuvezam, Grasiela Morais, Ana Heloneida de Araújo |
| author_sort |
Medeiros, Isaiane |
| title |
In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus a protocol for systematic review and meta analysis |
| title_short |
In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus a protocol for systematic review and meta analysis |
| title_full |
In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus a protocol for systematic review and meta analysis |
| title_fullStr |
In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus a protocol for systematic review and meta analysis |
| title_full_unstemmed |
In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus a protocol for systematic review and meta analysis |
| title_sort |
in silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus a protocol for systematic review and meta analysis |
| publisher |
Medicine |
| publishDate |
2023 |
| url |
https://repositorio.ufrn.br/handle/123456789/52492 |
| work_keys_str_mv |
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