Clinical presentation, outcomes, and treatment of membranous nephropathy after transplantation

There are scarce data about clinical presentation and outcomes of posttransplant membranous nephropathy (MN), and few reports include a large number of patients. This was a retrospective cohort including adult patients with posttransplant MN transplanted between 1983 and 2015 in a single center (n=4...

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Principais autores: Silva, Artur Quintiliano Bezerra da, Sandes-Freitas, Taina V. de, Mansur, Juliana B., Medicina-Pestana, Jose Osmar, Mastroianni-Kirsztajn, Gianna
Formato: article
Idioma:English
Publicado em: International Journal Of Nephrology
Assuntos:
membranous nephropathy
transplantation
posttransplant
Endereço do item:https://repositorio.ufrn.br/handle/123456789/52490
https://doi.org/10.1155/2018/3720591
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spelling ri-123456789-524902023-05-19T16:44:58Z Clinical presentation, outcomes, and treatment of membranous nephropathy after transplantation Silva, Artur Quintiliano Bezerra da Sandes-Freitas, Taina V. de Mansur, Juliana B. Medicina-Pestana, Jose Osmar Mastroianni-Kirsztajn, Gianna membranous nephropathy transplantation posttransplant There are scarce data about clinical presentation and outcomes of posttransplant membranous nephropathy (MN), and few reports include a large number of patients. This was a retrospective cohort including adult patients with posttransplant MN transplanted between 1983 and 2015 in a single center (n=41). Only patients with histological diagnosis of MN in kidney grafts were included. Clinical and laboratory presentation, histological findings, treatment, and outcomes were detailed. Patients were predominantly male (58.5%), with a mean age of 49.4 ± 13.2 years; 15 were considered as recurrent primary MN; 3 were class V lupus nephritis; 14 were considered as de novo cases, 7 secondary and 7 primary MN; and 9 cases were considered primary but it was not possible to distinguish between de novo MN and recurrence. Main clinical presentations were proteinuria (75.6%) and graft dysfunction (34.1%). Most patients with primary recurrent and de novo primary MN were submitted to changes in maintenance immunosuppressive regimen, but no standard strategy was identified; 31 patients presented partial or complete remission, and glomerulopathy appeared not to impact graft and patient survival. 2023-05-19T16:44:26Z 2023-05-19T16:44:26Z 2018-07-05 article SILVA, Artur Quintiliano Bezerra da; et al. Clinical Presentation, Outcomes, and Treatment of Membranous Nephropathy after Transplantation. International Journal Of Nephrology, [S.L.], v. 2018, p. 1-6, 5 jul. 2018. Hindawi Limited. http://dx.doi.org/10.1155/2018/3720591. Acesso em: 19 maio 2022. https://repositorio.ufrn.br/handle/123456789/52490 https://doi.org/10.1155/2018/3720591 en application/pdf International Journal Of Nephrology
institution Repositório Institucional
collection RI - UFRN
language English
topic membranous nephropathy
transplantation
posttransplant
spellingShingle membranous nephropathy
transplantation
posttransplant
Silva, Artur Quintiliano Bezerra da
Sandes-Freitas, Taina V. de
Mansur, Juliana B.
Medicina-Pestana, Jose Osmar
Mastroianni-Kirsztajn, Gianna
Clinical presentation, outcomes, and treatment of membranous nephropathy after transplantation
description There are scarce data about clinical presentation and outcomes of posttransplant membranous nephropathy (MN), and few reports include a large number of patients. This was a retrospective cohort including adult patients with posttransplant MN transplanted between 1983 and 2015 in a single center (n=41). Only patients with histological diagnosis of MN in kidney grafts were included. Clinical and laboratory presentation, histological findings, treatment, and outcomes were detailed. Patients were predominantly male (58.5%), with a mean age of 49.4 ± 13.2 years; 15 were considered as recurrent primary MN; 3 were class V lupus nephritis; 14 were considered as de novo cases, 7 secondary and 7 primary MN; and 9 cases were considered primary but it was not possible to distinguish between de novo MN and recurrence. Main clinical presentations were proteinuria (75.6%) and graft dysfunction (34.1%). Most patients with primary recurrent and de novo primary MN were submitted to changes in maintenance immunosuppressive regimen, but no standard strategy was identified; 31 patients presented partial or complete remission, and glomerulopathy appeared not to impact graft and patient survival.
format article
author Silva, Artur Quintiliano Bezerra da
Sandes-Freitas, Taina V. de
Mansur, Juliana B.
Medicina-Pestana, Jose Osmar
Mastroianni-Kirsztajn, Gianna
author_facet Silva, Artur Quintiliano Bezerra da
Sandes-Freitas, Taina V. de
Mansur, Juliana B.
Medicina-Pestana, Jose Osmar
Mastroianni-Kirsztajn, Gianna
author_sort Silva, Artur Quintiliano Bezerra da
title Clinical presentation, outcomes, and treatment of membranous nephropathy after transplantation
title_short Clinical presentation, outcomes, and treatment of membranous nephropathy after transplantation
title_full Clinical presentation, outcomes, and treatment of membranous nephropathy after transplantation
title_fullStr Clinical presentation, outcomes, and treatment of membranous nephropathy after transplantation
title_full_unstemmed Clinical presentation, outcomes, and treatment of membranous nephropathy after transplantation
title_sort clinical presentation, outcomes, and treatment of membranous nephropathy after transplantation
publisher International Journal Of Nephrology
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/52490
https://doi.org/10.1155/2018/3720591
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