NMDARs control object recognition memory destabilization and reconsolidation

Object recognition memory (ORM) allows identification of previously encountered items and is therefore crucial for remembering episodic information. In rodents, reactivation during recall in the presence of a novel object destabilizes ORM and initiates a Zif268 and protein synthesis-dependent recons...

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Principais autores: Rossato, Janine Inez, Radiske, Andressa, Gonzalez, Maria Carolina, Apolinário, Gênedy Karielly da Silva, Araújo, Raquel Lúcia Souto de, Bevilaqua, Lia Rejane Muller, Cammarota, Martín Pablo
Formato: article
Idioma:English
Publicado em: Elsevier BV
Assuntos:
Hippocampus
Recall
TCN201
AP5
RO25–6981
Memory consolidation
Endereço do item:https://repositorio.ufrn.br/handle/123456789/52229
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spelling ri-123456789-522292023-04-25T19:09:11Z NMDARs control object recognition memory destabilization and reconsolidation Rossato, Janine Inez Radiske, Andressa Gonzalez, Maria Carolina Apolinário, Gênedy Karielly da Silva Araújo, Raquel Lúcia Souto de Bevilaqua, Lia Rejane Muller Cammarota, Martín Pablo Hippocampus Recall TCN201 AP5 RO25–6981 Memory consolidation Object recognition memory (ORM) allows identification of previously encountered items and is therefore crucial for remembering episodic information. In rodents, reactivation during recall in the presence of a novel object destabilizes ORM and initiates a Zif268 and protein synthesis-dependent reconsolidation process in the hippocampus that links the memory of this object to the reactivated recognition trace. Hippocampal NMDA receptors (NMDARs) modulate Zif268 expression and protein synthesis and regulate memory stability but their possible involvement in the ORM destabilization/reconsolidation cycle has yet to be analyzed in detail. We found that, in adult male Wistar rats, intra dorsal-CA1 administration of the non-subunit selective NMDAR antagonist AP5, or of the GluN2A subunit-containing NMDAR antagonist TCN201, 5 min after an ORM reactivation session in the presence of a novel object carried out 24 h post-training impaired retention 24 h later. In contrast, pre-reactivation administration of the GluN2B subunit-containing NMDAR antagonist RO25-6981 had no effect on ORM recall or retention but impeded the amnesia caused by Zif268 silencing and protein synthesis inhibition in dorsal CA1. Our results indicate that GluN2B-containing hippocampal NMDARs are necessary for ORM destabilization whereas GluN2A-containing NMDARs are involved in ORM reconsolidation, and suggest that modulation of the relative activity of these receptor subtypes during recall regulates ORM persistence 2023-04-25T19:09:10Z 2023-04-25T19:09:10Z 2023-04 article ROSSATO, Janine I.; RADISKE, Andressa; GONZALEZ, Maria Carolina; APOLINÁRIO, Gênedy; ARAÚJO, Raquel L. S.; BEVILAQUA, Lia R. M.; CAMMAROTA, Martín. NMDARs control object recognition memory destabilization and reconsolidation. Brain Research Bulletin, [S. l.], v. 197, p. 42-48, jun. 2023. Doi: http://dx.doi.org/10.1016/j.brainresbull.2023.03.013. Disponível em: https://www.sciencedirect.com/science/article/pii/S0361923023000692?via%3Dihub. Acesso em: 25 abr. 2023. https://repositorio.ufrn.br/handle/123456789/52229 10.1016/j.brainresbull.2023.03.013 en Atribuição-NãoComercial-SemDerivados 3.0 Brasil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Elsevier BV
institution Repositório Institucional
collection RI - UFRN
language English
topic Hippocampus
Recall
TCN201
AP5
RO25–6981
Memory consolidation
spellingShingle Hippocampus
Recall
TCN201
AP5
RO25–6981
Memory consolidation
Rossato, Janine Inez
Radiske, Andressa
Gonzalez, Maria Carolina
Apolinário, Gênedy Karielly da Silva
Araújo, Raquel Lúcia Souto de
Bevilaqua, Lia Rejane Muller
Cammarota, Martín Pablo
NMDARs control object recognition memory destabilization and reconsolidation
description Object recognition memory (ORM) allows identification of previously encountered items and is therefore crucial for remembering episodic information. In rodents, reactivation during recall in the presence of a novel object destabilizes ORM and initiates a Zif268 and protein synthesis-dependent reconsolidation process in the hippocampus that links the memory of this object to the reactivated recognition trace. Hippocampal NMDA receptors (NMDARs) modulate Zif268 expression and protein synthesis and regulate memory stability but their possible involvement in the ORM destabilization/reconsolidation cycle has yet to be analyzed in detail. We found that, in adult male Wistar rats, intra dorsal-CA1 administration of the non-subunit selective NMDAR antagonist AP5, or of the GluN2A subunit-containing NMDAR antagonist TCN201, 5 min after an ORM reactivation session in the presence of a novel object carried out 24 h post-training impaired retention 24 h later. In contrast, pre-reactivation administration of the GluN2B subunit-containing NMDAR antagonist RO25-6981 had no effect on ORM recall or retention but impeded the amnesia caused by Zif268 silencing and protein synthesis inhibition in dorsal CA1. Our results indicate that GluN2B-containing hippocampal NMDARs are necessary for ORM destabilization whereas GluN2A-containing NMDARs are involved in ORM reconsolidation, and suggest that modulation of the relative activity of these receptor subtypes during recall regulates ORM persistence
format article
author Rossato, Janine Inez
Radiske, Andressa
Gonzalez, Maria Carolina
Apolinário, Gênedy Karielly da Silva
Araújo, Raquel Lúcia Souto de
Bevilaqua, Lia Rejane Muller
Cammarota, Martín Pablo
author_facet Rossato, Janine Inez
Radiske, Andressa
Gonzalez, Maria Carolina
Apolinário, Gênedy Karielly da Silva
Araújo, Raquel Lúcia Souto de
Bevilaqua, Lia Rejane Muller
Cammarota, Martín Pablo
author_sort Rossato, Janine Inez
title NMDARs control object recognition memory destabilization and reconsolidation
title_short NMDARs control object recognition memory destabilization and reconsolidation
title_full NMDARs control object recognition memory destabilization and reconsolidation
title_fullStr NMDARs control object recognition memory destabilization and reconsolidation
title_full_unstemmed NMDARs control object recognition memory destabilization and reconsolidation
title_sort nmdars control object recognition memory destabilization and reconsolidation
publisher Elsevier BV
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/52229
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