Estudo de Desreplicação do Extrato das Sementes de Aspidosperma Pyrifolium, com o uso de CG-EM
The species Aspidosperma pyrifolium (apocynaceae), known as "pereiro", is used in popular medicine as a potential antimalarial, gastroprotective, contraceptive and anti-inflammatory agent, among other activities. Such properties are correlated to the fact that the species contains indolic...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
| Publicado em: |
Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/51876 |
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| Resumo: | The species Aspidosperma pyrifolium (apocynaceae), known as "pereiro", is used in popular medicine as a potential antimalarial, gastroprotective, contraceptive and anti-inflammatory agent, among other activities. Such properties are correlated to the fact that the species contains indolic alkaloids, substances of great chemical and biological interest, due to the numerous properties demonstrated in the literature. In view of this, the study aims to apply the method of disentanglement through GC-MS analysis (Gas Chromatography Coupled to Mass
Spectrometry) from fractions of the seeds of this species in order to make notes of the indolic alkaloids, present that may be responsible for such biological activities. The species was chosen because it is common in the northeast region, being easily found in the state of Rio Grande do Norte, especially in the caatinga biome. The analyses obtained from GC-MS allowed the annotation of indolic alkaloids of the aspidospermate core type, already known from the species. As well as the alkaloid 4,4'-diphenyl-2,2'-dipyridyl and the steroid
gamma-sitosterol, so far not reported in the literature of the species, by comparison of NIST Lybrary (National Institute of Standards and Technology Lybrary data. Through this study, it was confirmed the need to stimulate the development of techniques for the extraction, isolation and identification of substances, especially the indolic alkaloids present in A. pyrifolium. |
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