On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory

c-Jun N-terminal kinase (JNK) phosphorylates the transcription factor c-Jun in response to stress stimuli and contributes to both hippocampal synaptic plasticity and memory processing in mammals. Object recognition memory (ORM) is essential for remembering facts and events. In rodents, ORM consolida...

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Principais autores: Rossato, Janine Inez, Radiske, Andressa, Gonzalez, Maria Carolina, Bevilaqua, Lia Rejane Muller, Cammarota, Martín Pablo
Formato: article
Idioma:English
Publicado em: Frontiers Media SA
Assuntos:
Memory - Consolidation
Memory - Reconsolidation
Object recognition memory (ORM)
JNK mitogen-activated protein kinases
Memory, short-term
Hippocampus
SP600125
Endereço do item:https://repositorio.ufrn.br/handle/123456789/51230
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spelling ri-123456789-512302023-02-08T11:55:36Z On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory Rossato, Janine Inez Radiske, Andressa Gonzalez, Maria Carolina Bevilaqua, Lia Rejane Muller Cammarota, Martín Pablo Memory - Consolidation Memory - Reconsolidation Object recognition memory (ORM) JNK mitogen-activated protein kinases Memory, short-term Hippocampus SP600125 c-Jun N-terminal kinase (JNK) phosphorylates the transcription factor c-Jun in response to stress stimuli and contributes to both hippocampal synaptic plasticity and memory processing in mammals. Object recognition memory (ORM) is essential for remembering facts and events. In rodents, ORM consolidation and reconsolidation require a functional hippocampus. However, the possible involvement of hippocampal JNK on ORM processing has not yet been studied. Here we show that when injected into dorsal CA1 5 min, but not 6 h, after training adult male rats in the novel object recognition learning task, the JNK inhibitor SP600125 impaired ORM for at least 7 days without affecting exploratory activity, short-term ORM retention, or the functional integrity of the hippocampus. SP600125 did not hinder ORM retention when given in CA1 after a memory reactivation session carried out 24 h post-training in the presence of the same two objects presented during the training session, but caused time-dependent amnesia when one of the objects presented at training was replaced by a different but behaviorally equivalent novel one. Taken together, our results indicate that hippocampal JNK activity is necessary for ORM consolidation and reconsolidation but not for ORM recall or short-term retention 2023-02-08T11:55:35Z 2023-02-08T11:55:35Z 2022-12 article ROSSATO, Janine I.; RADISKE, Andressa; GONZALEZ, Maria Carolina; BEVILAQUA, Lia R. M.; CAMMAROTA, Martín. On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory. Frontiers In Behavioral Neuroscience, [S. l.], v. 16, p. 1052124, dez. 2022. Doi: http://dx.doi.org/10.3389/fnbeh.2022.1052124. Disponível em: https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1052124/full. Acesso em: 06 fev. 2023. https://repositorio.ufrn.br/handle/123456789/51230 10.3389/fnbeh.2022.1052124 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Frontiers Media SA
institution Repositório Institucional
collection RI - UFRN
language English
topic Memory - Consolidation
Memory - Reconsolidation
Object recognition memory (ORM)
JNK mitogen-activated protein kinases
Memory, short-term
Hippocampus
SP600125
spellingShingle Memory - Consolidation
Memory - Reconsolidation
Object recognition memory (ORM)
JNK mitogen-activated protein kinases
Memory, short-term
Hippocampus
SP600125
Rossato, Janine Inez
Radiske, Andressa
Gonzalez, Maria Carolina
Bevilaqua, Lia Rejane Muller
Cammarota, Martín Pablo
On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
description c-Jun N-terminal kinase (JNK) phosphorylates the transcription factor c-Jun in response to stress stimuli and contributes to both hippocampal synaptic plasticity and memory processing in mammals. Object recognition memory (ORM) is essential for remembering facts and events. In rodents, ORM consolidation and reconsolidation require a functional hippocampus. However, the possible involvement of hippocampal JNK on ORM processing has not yet been studied. Here we show that when injected into dorsal CA1 5 min, but not 6 h, after training adult male rats in the novel object recognition learning task, the JNK inhibitor SP600125 impaired ORM for at least 7 days without affecting exploratory activity, short-term ORM retention, or the functional integrity of the hippocampus. SP600125 did not hinder ORM retention when given in CA1 after a memory reactivation session carried out 24 h post-training in the presence of the same two objects presented during the training session, but caused time-dependent amnesia when one of the objects presented at training was replaced by a different but behaviorally equivalent novel one. Taken together, our results indicate that hippocampal JNK activity is necessary for ORM consolidation and reconsolidation but not for ORM recall or short-term retention
format article
author Rossato, Janine Inez
Radiske, Andressa
Gonzalez, Maria Carolina
Bevilaqua, Lia Rejane Muller
Cammarota, Martín Pablo
author_facet Rossato, Janine Inez
Radiske, Andressa
Gonzalez, Maria Carolina
Bevilaqua, Lia Rejane Muller
Cammarota, Martín Pablo
author_sort Rossato, Janine Inez
title On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
title_short On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
title_full On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
title_fullStr On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
title_full_unstemmed On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
title_sort on the effect of hippocampal c-jun n-terminal kinase inhibition on object recognition memory
publisher Frontiers Media SA
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/51230
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AT gonzalezmariacarolina ontheeffectofhippocampalcjunnterminalkinaseinhibitiononobjectrecognitionmemory
AT bevilaqualiarejanemuller ontheeffectofhippocampalcjunnterminalkinaseinhibitiononobjectrecognitionmemory
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