Moderators of ayahuasca’s biological antidepressant action

Introduction: The understanding of biological responses to psychedelics with antidepressant potential is imperative. Here we report how a set of acute parameters, namely emotional (depressive symptoms), cognitive (psychedelic experience), and physiological (salivary cortisol), recorded during an aya...

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Principais autores: Sousa Júnior, Geovan Menezes de, Tavares, Vagner Deuel de Oliveira, Galvão, Ana Cecília de Menezes, Almeida, Raíssa Nóbrega de, Fontes, Fernanda Palhano Xavier de, Soares, Bruno Lobão, Freire, Fúlvio Aurélio de Morais, Nunes, Emerson Arcoverde, Oliveira, João Paulo Maia de, Perkins, Daniel, Sarris, Jerome, Araujo, Draulio Barros de, Coelho, Nicole Leite Galvão
Formato: article
Idioma:English
Publicado em: Frontiers Media SA
Assuntos:
Brain-derived neurotrophic factor
Hydrocortisone
Cortisol
Depression
Hallucinogens
Psychedelics
Banisteriopsis
Ayahuasca
Endereço do item:https://repositorio.ufrn.br/handle/123456789/51078
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spelling ri-123456789-510782023-01-30T13:01:27Z Moderators of ayahuasca’s biological antidepressant action Sousa Júnior, Geovan Menezes de Tavares, Vagner Deuel de Oliveira Galvão, Ana Cecília de Menezes Almeida, Raíssa Nóbrega de Fontes, Fernanda Palhano Xavier de Soares, Bruno Lobão Freire, Fúlvio Aurélio de Morais Nunes, Emerson Arcoverde Oliveira, João Paulo Maia de Perkins, Daniel Sarris, Jerome Araujo, Draulio Barros de Coelho, Nicole Leite Galvão Brain-derived neurotrophic factor Hydrocortisone Cortisol Depression Hallucinogens Psychedelics Banisteriopsis Ayahuasca Introduction: The understanding of biological responses to psychedelics with antidepressant potential is imperative. Here we report how a set of acute parameters, namely emotional (depressive symptoms), cognitive (psychedelic experience), and physiological (salivary cortisol), recorded during an ayahuasca dosing session, modulated serum brain-derived neurotrophic factor (BDNF), serum cortisol (SC), serum interleukin 6 (IL-6), plasma C-reactive protein (CRP), and salivary cortisol awakening response (CAR). Methods: Results were analyzed 2 days after the psychedelic intervention (ayahuasca) versus placebo in both patients with treatment-resistant depression and healthy volunteers. These measures were assessed as part of a randomized double-blinded, placebo-controlled trial (n = 72). Results: Results revealed that larger reductions of depressive symptoms during the dosing session significantly moderated higher levels of SC in patients. Whereas lesser changes in salivary cortisol levels during the ayahuasca intervention were related to higher BDNF levels in patients with a larger clinical response in the reduction in depressive symptoms. No moderator was found for patient's CAR, IL-6, and CRP responses to ayahuasca and for all biomarker responses to ayahuasca in healthy controls and in the placebo group. Discussion: In summary, some specific emotional and physiological parameters during experimental ayahuasca session were revealed as critical moderators of the improvement of major depression biomarkers, mainly BDNF and SC two days after ayahuasca intake. These findings contribute to paving the way for future studies investigating the biological antidepressant response to psychedelic therapy 2023-01-30T13:01:22Z 2023-01-30T13:01:22Z 2022-12 article SOUSA, Geovan Menezes de; TAVARES, Vagner Deuel de Oliveira; GALVÃO, Ana Cecília de Menezes; ALMEIDA, Raíssa Nóbrega de; PALHANO-FONTES, Fernanda; LOBÃO-SOARES, Bruno; FREIRE, Fúlvio Aurélio de Morais; NUNES, Emerson Arcoverde; MAIA-DE-OLIVEIRA, João Paulo; PERKINS, Daniel; SARRIS, Jerome; ARAUJO, Draulio Barros de; GALVÃO-COELHO, Nicole Leite. Moderators of ayahuasca’s biological antidepressant action. Frontiers In Psychiatry, [S. l.], v. 13, p. 1033816, dez. 2022. Doi: http://dx.doi.org/10.3389/fpsyt.2022.1033816. Disponível em: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1033816/full. Acesso em: 30 jan. 2023 https://repositorio.ufrn.br/handle/123456789/51078 10.3389/fpsyt.2022.1033816 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Frontiers Media SA
institution Repositório Institucional
collection RI - UFRN
language English
topic Brain-derived neurotrophic factor
Hydrocortisone
Cortisol
Depression
Hallucinogens
Psychedelics
Banisteriopsis
Ayahuasca
spellingShingle Brain-derived neurotrophic factor
Hydrocortisone
Cortisol
Depression
Hallucinogens
Psychedelics
Banisteriopsis
Ayahuasca
Sousa Júnior, Geovan Menezes de
Tavares, Vagner Deuel de Oliveira
Galvão, Ana Cecília de Menezes
Almeida, Raíssa Nóbrega de
Fontes, Fernanda Palhano Xavier de
Soares, Bruno Lobão
Freire, Fúlvio Aurélio de Morais
Nunes, Emerson Arcoverde
Oliveira, João Paulo Maia de
Perkins, Daniel
Sarris, Jerome
Araujo, Draulio Barros de
Coelho, Nicole Leite Galvão
Moderators of ayahuasca’s biological antidepressant action
description Introduction: The understanding of biological responses to psychedelics with antidepressant potential is imperative. Here we report how a set of acute parameters, namely emotional (depressive symptoms), cognitive (psychedelic experience), and physiological (salivary cortisol), recorded during an ayahuasca dosing session, modulated serum brain-derived neurotrophic factor (BDNF), serum cortisol (SC), serum interleukin 6 (IL-6), plasma C-reactive protein (CRP), and salivary cortisol awakening response (CAR). Methods: Results were analyzed 2 days after the psychedelic intervention (ayahuasca) versus placebo in both patients with treatment-resistant depression and healthy volunteers. These measures were assessed as part of a randomized double-blinded, placebo-controlled trial (n = 72). Results: Results revealed that larger reductions of depressive symptoms during the dosing session significantly moderated higher levels of SC in patients. Whereas lesser changes in salivary cortisol levels during the ayahuasca intervention were related to higher BDNF levels in patients with a larger clinical response in the reduction in depressive symptoms. No moderator was found for patient's CAR, IL-6, and CRP responses to ayahuasca and for all biomarker responses to ayahuasca in healthy controls and in the placebo group. Discussion: In summary, some specific emotional and physiological parameters during experimental ayahuasca session were revealed as critical moderators of the improvement of major depression biomarkers, mainly BDNF and SC two days after ayahuasca intake. These findings contribute to paving the way for future studies investigating the biological antidepressant response to psychedelic therapy
format article
author Sousa Júnior, Geovan Menezes de
Tavares, Vagner Deuel de Oliveira
Galvão, Ana Cecília de Menezes
Almeida, Raíssa Nóbrega de
Fontes, Fernanda Palhano Xavier de
Soares, Bruno Lobão
Freire, Fúlvio Aurélio de Morais
Nunes, Emerson Arcoverde
Oliveira, João Paulo Maia de
Perkins, Daniel
Sarris, Jerome
Araujo, Draulio Barros de
Coelho, Nicole Leite Galvão
author_facet Sousa Júnior, Geovan Menezes de
Tavares, Vagner Deuel de Oliveira
Galvão, Ana Cecília de Menezes
Almeida, Raíssa Nóbrega de
Fontes, Fernanda Palhano Xavier de
Soares, Bruno Lobão
Freire, Fúlvio Aurélio de Morais
Nunes, Emerson Arcoverde
Oliveira, João Paulo Maia de
Perkins, Daniel
Sarris, Jerome
Araujo, Draulio Barros de
Coelho, Nicole Leite Galvão
author_sort Sousa Júnior, Geovan Menezes de
title Moderators of ayahuasca’s biological antidepressant action
title_short Moderators of ayahuasca’s biological antidepressant action
title_full Moderators of ayahuasca’s biological antidepressant action
title_fullStr Moderators of ayahuasca’s biological antidepressant action
title_full_unstemmed Moderators of ayahuasca’s biological antidepressant action
title_sort moderators of ayahuasca’s biological antidepressant action
publisher Frontiers Media SA
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/51078
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