Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil

Purpose This cross-sectional study aimed to estimate the prevalence of Chlamydia trachomatis (CT) infection alone and in combination with human papillomavirus (HPV). Furthermore, the study investigates whether the CT infection increases the risk of contracting HPV and whether the presence of both pa...

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Principais autores:	Magalhães, Paulo André Freire, Miranda, Cleine Aglacy Nunes, Lima, Érika Galvão, Moizéis, Raíza Nara Cunha, Lima, Diego Breno Soares de, Cobucci, Ricardo Ney Oliveira, Fernandes, Thales Allyrio Araújo de Medeiros, Azevedo, Jenner Chrystian Veríssimo de, Azevedo, Paulo Roberto Medeiros de, Araújo, Josélio Maria Galvão de, Fernandes, José Veríssimo
Formato:	article
Idioma:	English
Publicado em:	Springer
Assuntos:	Chlamydia trachomatis Human papillomavirus Risk factors Genital tract infection
Endereço do item:	https://repositorio.ufrn.br/handle/123456789/50970
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spelling	ri-123456789-509702023-01-16T22:04:15Z Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil Magalhães, Paulo André Freire Miranda, Cleine Aglacy Nunes Lima, Érika Galvão Moizéis, Raíza Nara Cunha Lima, Diego Breno Soares de Cobucci, Ricardo Ney Oliveira Fernandes, Thales Allyrio Araújo de Medeiros Azevedo, Jenner Chrystian Veríssimo de Azevedo, Paulo Roberto Medeiros de Araújo, Josélio Maria Galvão de Fernandes, José Veríssimo Chlamydia trachomatis Human papillomavirus Risk factors Genital tract infection Purpose This cross-sectional study aimed to estimate the prevalence of Chlamydia trachomatis (CT) infection alone and in combination with human papillomavirus (HPV). Furthermore, the study investigates whether the CT infection increases the risk of contracting HPV and whether the presence of both pathogens is associated with a higher prevalence of cervical lesions. Methods Cervical samples of 1,134 asymptomatic women enrolled in a screening program for cervical cancer were analyzed. Two cervical specimens were collected from each patient, one for cytologic examination and the other for detection of CT by polymerase chain reaction (PCR), using a primer pair which amplifies a specific sequence of the DNA plasmid. Results The overall prevalence rate infection was 10.9 %, being 10 % in the women with normal cytology, 13.8 % in those with atypical squamous cells of undetermined significance (ASC-US), and 25 % with low-grade squamous intraepithelial lesion (LSIL). The infection by CT did not increase the risk of acquiring HPV infection. The higher prevalence of LSIL in women co-infected with HPV and CT is possibly due to HPV. Conclusion CT infection was more prevalent in younger women aged up to 32 years, who had an early onset of reproductive activity and a history of having had multiple sexual partners lifelong may be at a greater risk of acquiring infection of the genital tract by C. trachomatis. 2023-01-16T22:04:14Z 2023-01-16T22:04:14Z 2014-10 article MAGALHÃES, Paulo André F. et al. Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil. Archives of Gynecology and Obstetrics, v. 2015, p. 1095-1102, 2014. Disponível em: https://link.springer.com/article/10.1007%2Fs00404-014-3514-z. Acesso em: 08 dez. 2017. https://repositorio.ufrn.br/handle/123456789/50970 10.1007/s00404-014-3514-z en Acesso Aberto application/pdf Springer
institution	Repositório Institucional
collection	RI - UFRN
language	English
topic	Chlamydia trachomatis Human papillomavirus Risk factors Genital tract infection
spellingShingle	Chlamydia trachomatis Human papillomavirus Risk factors Genital tract infection Magalhães, Paulo André Freire Miranda, Cleine Aglacy Nunes Lima, Érika Galvão Moizéis, Raíza Nara Cunha Lima, Diego Breno Soares de Cobucci, Ricardo Ney Oliveira Fernandes, Thales Allyrio Araújo de Medeiros Azevedo, Jenner Chrystian Veríssimo de Azevedo, Paulo Roberto Medeiros de Araújo, Josélio Maria Galvão de Fernandes, José Veríssimo Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
description	Purpose This cross-sectional study aimed to estimate the prevalence of Chlamydia trachomatis (CT) infection alone and in combination with human papillomavirus (HPV). Furthermore, the study investigates whether the CT infection increases the risk of contracting HPV and whether the presence of both pathogens is associated with a higher prevalence of cervical lesions. Methods Cervical samples of 1,134 asymptomatic women enrolled in a screening program for cervical cancer were analyzed. Two cervical specimens were collected from each patient, one for cytologic examination and the other for detection of CT by polymerase chain reaction (PCR), using a primer pair which amplifies a specific sequence of the DNA plasmid. Results The overall prevalence rate infection was 10.9 %, being 10 % in the women with normal cytology, 13.8 % in those with atypical squamous cells of undetermined significance (ASC-US), and 25 % with low-grade squamous intraepithelial lesion (LSIL). The infection by CT did not increase the risk of acquiring HPV infection. The higher prevalence of LSIL in women co-infected with HPV and CT is possibly due to HPV. Conclusion CT infection was more prevalent in younger women aged up to 32 years, who had an early onset of reproductive activity and a history of having had multiple sexual partners lifelong may be at a greater risk of acquiring infection of the genital tract by C. trachomatis.
format	article
author	Magalhães, Paulo André Freire Miranda, Cleine Aglacy Nunes Lima, Érika Galvão Moizéis, Raíza Nara Cunha Lima, Diego Breno Soares de Cobucci, Ricardo Ney Oliveira Fernandes, Thales Allyrio Araújo de Medeiros Azevedo, Jenner Chrystian Veríssimo de Azevedo, Paulo Roberto Medeiros de Araújo, Josélio Maria Galvão de Fernandes, José Veríssimo
author_facet	Magalhães, Paulo André Freire Miranda, Cleine Aglacy Nunes Lima, Érika Galvão Moizéis, Raíza Nara Cunha Lima, Diego Breno Soares de Cobucci, Ricardo Ney Oliveira Fernandes, Thales Allyrio Araújo de Medeiros Azevedo, Jenner Chrystian Veríssimo de Azevedo, Paulo Roberto Medeiros de Araújo, Josélio Maria Galvão de Fernandes, José Veríssimo
author_sort	Magalhães, Paulo André Freire
title	Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
title_short	Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
title_full	Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
title_fullStr	Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
title_full_unstemmed	Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
title_sort	genital tract infection with chlamydia trachomatis in women attended at a cervical cancer screening program in northeastern from brazil
publisher	Springer
publishDate	2023
url	https://repositorio.ufrn.br/handle/123456789/50970
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Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil

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