Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts

Objective: Receptor activator of nuclear factor-kB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are members of the superfamily of ligands and receptors of tumour necrosis factor family involved in bone metabolism. The formation, differentiation and activity of osteoclasts are regulated b...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Moraes, Maiara de, Lucena, Hévio Freitas de, Azevedo, Paulo Roberto Medeiros de, Queiroz, Lélia Maria Guedes, Costa, Antonio de Lisboa Lopes
Formato: article
Idioma:English
Publicado em: Elsevier
Assuntos:
Radicular cyst
Dentigerous cyst
Receptor activator of nuclear
Factor-kB
RANK ligand and osteoprotegerin
Endereço do item:https://repositorio.ufrn.br/handle/123456789/50964
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id ri-123456789-50964
record_format dspace
spelling ri-123456789-509642023-01-16T20:34:05Z Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts Moraes, Maiara de Lucena, Hévio Freitas de Azevedo, Paulo Roberto Medeiros de Queiroz, Lélia Maria Guedes Costa, Antonio de Lisboa Lopes Radicular cyst Dentigerous cyst Receptor activator of nuclear Factor-kB RANK ligand and osteoprotegerin Objective: Receptor activator of nuclear factor-kB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are members of the superfamily of ligands and receptors of tumour necrosis factor family involved in bone metabolism. The formation, differentiation and activity of osteoclasts are regulated by these proteins. To clarify the roles of osteoclast regulatory factors in cystic expansion of odontogenic cysts, expression of these proteins were analysed in radicular and dentigerous cysts. Design: The immunohistochemistry expression of these biomarkers were evaluated and measured in lining epithelium and fibrous capsule of the radicular (n = 20) and dentigerous cysts (n = 20). Results: A similar expression in lining epithelium was observed in the lesions. The fibrous capsule of dentigerous cyst showed a higher content of RANK-positive and RANKL-positive cells than fibrous capsule of radicular cyst. In the lining epithelium the RANKL/OPG ratio showed higher numbers of OPG-positive than RANKL-positive cells, whereas fibrous capsule of the cysts had a tendency to present a similar expression (OPG = RANKL). Conclusion: Ours findings indicate the presence of RANK, RANKL and OPG in cysts. Moreover, increased expression of OPG compared to RANKL in the lining epithelium could contribute to the differential bone resorption activity in theses lesions. 2023-01-16T20:34:04Z 2023-01-16T20:34:04Z 2011-05 article MORAES, Mayara et al. Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts. Archives of Oral Biology, v. 56, p. 1256-1263, 2011. Disponível em: http://www.sciencedirect.com/science/article/pii/S0003996911001634. Acesso em 08 dez. 2017 https://repositorio.ufrn.br/handle/123456789/50964 10.1016/j.archoralbio.2011.05.009 en Acesso Aberto application/pdf Elsevier
institution Repositório Institucional
collection RI - UFRN
language English
topic Radicular cyst
Dentigerous cyst
Receptor activator of nuclear
Factor-kB
RANK ligand and osteoprotegerin
spellingShingle Radicular cyst
Dentigerous cyst
Receptor activator of nuclear
Factor-kB
RANK ligand and osteoprotegerin
Moraes, Maiara de
Lucena, Hévio Freitas de
Azevedo, Paulo Roberto Medeiros de
Queiroz, Lélia Maria Guedes
Costa, Antonio de Lisboa Lopes
Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts
description Objective: Receptor activator of nuclear factor-kB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are members of the superfamily of ligands and receptors of tumour necrosis factor family involved in bone metabolism. The formation, differentiation and activity of osteoclasts are regulated by these proteins. To clarify the roles of osteoclast regulatory factors in cystic expansion of odontogenic cysts, expression of these proteins were analysed in radicular and dentigerous cysts. Design: The immunohistochemistry expression of these biomarkers were evaluated and measured in lining epithelium and fibrous capsule of the radicular (n = 20) and dentigerous cysts (n = 20). Results: A similar expression in lining epithelium was observed in the lesions. The fibrous capsule of dentigerous cyst showed a higher content of RANK-positive and RANKL-positive cells than fibrous capsule of radicular cyst. In the lining epithelium the RANKL/OPG ratio showed higher numbers of OPG-positive than RANKL-positive cells, whereas fibrous capsule of the cysts had a tendency to present a similar expression (OPG = RANKL). Conclusion: Ours findings indicate the presence of RANK, RANKL and OPG in cysts. Moreover, increased expression of OPG compared to RANKL in the lining epithelium could contribute to the differential bone resorption activity in theses lesions.
format article
author Moraes, Maiara de
Lucena, Hévio Freitas de
Azevedo, Paulo Roberto Medeiros de
Queiroz, Lélia Maria Guedes
Costa, Antonio de Lisboa Lopes
author_facet Moraes, Maiara de
Lucena, Hévio Freitas de
Azevedo, Paulo Roberto Medeiros de
Queiroz, Lélia Maria Guedes
Costa, Antonio de Lisboa Lopes
author_sort Moraes, Maiara de
title Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts
title_short Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts
title_full Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts
title_fullStr Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts
title_full_unstemmed Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts
title_sort comparative immunohistochemical expression of rank, rankl and opg in radicular and dentigerous cysts
publisher Elsevier
publishDate 2023
url https://repositorio.ufrn.br/handle/123456789/50964
work_keys_str_mv AT moraesmaiarade comparativeimmunohistochemicalexpressionofrankranklandopginradicularanddentigerouscysts
AT lucenaheviofreitasde comparativeimmunohistochemicalexpressionofrankranklandopginradicularanddentigerouscysts
AT azevedopaulorobertomedeirosde comparativeimmunohistochemicalexpressionofrankranklandopginradicularanddentigerouscysts
AT queirozleliamariaguedes comparativeimmunohistochemicalexpressionofrankranklandopginradicularanddentigerouscysts
AT costaantoniodelisboalopes comparativeimmunohistochemicalexpressionofrankranklandopginradicularanddentigerouscysts
_version_ 1773966420765310976

Registros relacionados