Revisão de literatura: análise de métodos de diagnóstico e de tratamento para pacientes com trombocitopenia imune primária
Within the set of diseases characterized by an individual's hemostatic alteration, there is immune thrombocytopenia (ITP), a disorder marked by an insufficient number of platelets due to autoimmune processes. The damage caused ranges from the appearance of petechiae to even, in more extreme cas...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/50923 |
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| Resumo: | Within the set of diseases characterized by an individual's hemostatic alteration, there is immune thrombocytopenia (ITP), a disorder marked by an insufficient number of platelets due to autoimmune processes. The damage caused ranges from the appearance of petechiae to even, in more extreme cases, the death of the patient. Although there are studies with new perspectives on the diagnosis and treatment of the disease, there is still no cure for all existing types of ITP and the diagnosis is often costly, since it is a rare and silent condition. This work consists of a bibliographic review regarding the methods of diagnosis and treatment of immune thrombocytopenia in its primary form, using the descriptors “autoimmune thrombocytopenia”; “pseudothrombocytopenia”; “treatment”; “diagnosis”; “splenectomy”; “intravenous immunoglobulin”; “corticosteroid”, in addition to the PubMed and Google Scholar indexes. After associating the mechanisms of action of the drugs with the pathophysiology of the disease, it was observed that certain treatments, especially the prolonged use of corticosteroids and intravenous immunoglobulins, can bring even more complications to the patient, in addition to those already caused by the disease itself. The differential diagnosis of ITP requires the patient's platelet count, in addition to an accurate anamnesis to exclude other diseases also characterized by thrombocytopenia. In conclusion, we highlight the need to shorten the time for a conclusive diagnosis and the development of new therapeutic platforms characteristically with limited adverse effects. |
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