Hemoglobina Glicada A1c (HbA1c) e desempenho físico em idosos de diferentes contextos epidemiológicos de envelhecimento - resultados longitudinais do International Mobility in Aging Study (IMIAS)
Introduction: Glycated Hemoglobin A1c refers to a blood marker that reflects glucose levels in the body for up to 3 months prior to assessment. The relationship between Hemoglobin A1c (HbA1c) and physical performance in older people has been discussed but has not yet been clearly established. The...
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| Formato: | Dissertação |
| Lenguaje: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Acceso en línea: | https://repositorio.ufrn.br/handle/123456789/50811 |
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| Sumario: | Introduction: Glycated Hemoglobin A1c refers to a blood marker that reflects glucose
levels in the body for up to 3 months prior to assessment. The relationship between
Hemoglobin A1c (HbA1c) and physical performance in older people has been discussed
but has not yet been clearly established. The evaluation of some measures becomes
fundamental in the global assessment of the health of the older people, especially
regarding physical functioning. The International Mobility in Aging Study (IMIAS) offers a
valuable opportunity to analyze the relationship between HbA1c levels and physical
performance in older people, as it holds a range of information obtained from biochemical
and functional analyses. Objectives and Hypotheses: This study aimed to evaluate the
longitudinal relationship between HbA1c and physical performance scores in different
epidemiological contexts of aging. Our hypothesis is that high levels of HbA1c may cause
decreased physical performance in this population, considering possible influences of
gender and sociodemographic aspects. Methods: Longitudinal data of 1,337 older
people from three countries (Canada, Brazil, and Colombia) from IMIAS were used to
assess the relationship between HbA1c and Short Physical Performance Battery (SPPB)
scores between 2012 and 2016. Linear Mixed Models grouped by sex and adjusted by
Age, Study site, Chronic Conditions, Anthropometric Measures, and Inflammatory Level
were used to estimate the influence of HbA1c on SPPB scores, adjusted by covariates.
Results: At the IMIAS baseline, Latin American (LA) cities had higher HbA1c averages
compared to Canadian cities, with Natal (Brazil) being the city with the highest HbA1c
averages in men and women (6.32 ± 1.49; 6,56 ± 1.70 respectively). SPPB scores were
significantly lower in LA cities, and older people in Natal had lower SPPB averages in
men (9.67 ± 2.38; p-value < 0.05) and women (8.52 ± 2.33; p-value <0.05). In the
multivariate mixed linear models of longitudinal analyses, HbA1c was significantly
associated with lower SPPB scores in men (β = -0.25, 95% CI: -0.39 to -0.12, p-value =
0.02) but not in women. Conclusions: High HbA1c levels at IMIAS baseline were
longitudinally associated with reductions in SPPB scores of older people from different
countries, however this association was observed only in men and not in women in the fully adjusted regression models. This study highlights a possible influence of gender on
this relationship. |
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