Formulação de nanoemulsão contendo o óleo de andiroba

Antimicrobials were and continue to be very important for humanity, since they managed to reduce deaths caused by diseases caused by microorganisms. However, the use of these drugs was inadequate, which generated resistance on the part of these living beings and made the use of some drugs unfe...

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Autor principal: Pires, Pedro Vinícius Matias
Outros Autores: Silva Júnior, Arnóbio Antônio da
Formato: bachelorThesis
Idioma:pt_BR
Publicado em: Universidade Federal do Rio Grande do Norte
Assuntos:
Antimicrobiano
Nanotecnologia
Óleo de andiroba
Nanoemulsão
Inversão de fases
CNPQ::CIENCIAS DA SAUDE
Endereço do item:https://repositorio.ufrn.br/handle/123456789/50426
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spelling ri-123456789-504262022-12-21T21:49:12Z Formulação de nanoemulsão contendo o óleo de andiroba Pires, Pedro Vinícius Matias Silva Júnior, Arnóbio Antônio da http://lattes.cnpq.br/4688178238600771 Pereira, Eron Lincoln Alves Antimicrobiano Nanotecnologia Óleo de andiroba Nanoemulsão Inversão de fases CNPQ::CIENCIAS DA SAUDE Antimicrobials were and continue to be very important for humanity, since they managed to reduce deaths caused by diseases caused by microorganisms. However, the use of these drugs was inadequate, which generated resistance on the part of these living beings and made the use of some drugs unfeasible at present, hence the importance of developing new drug therapies against these organisms. The andiroba is a tree that is very present in the Amazon region and was already used by the indigenous people of that town for various therapeutic purposes. Some studies sought to investigate part of these medicinal properties. However, these studies had not worked with the fixed oil of the plant, and few addressed the antimicrobial effect. Because of this, the use of nanotechnology was considered to develop a nanoemulsion with andiroba oil. Therefore, the objective of this work was to develop and characterize a nanoemulsion formulation containing fixed andiroba oil filtered by a low shear technique, through phase inversion. The prepared formulation was characterized by analyzing the particle diameter, the Polydispersion Index, the Zeta Potential and the Hydrogen Ionic Potential. In fact, it was possible to develop a stable nanoemulsion, in addition to characterizing the concentration of oil and the proportion of surfactants suitable for its use. Os antimicrobianos foram e ainda são muito importantes para a humanidade, pois conseguiram reduzir a morte provocada por doenças ocasionadas por microrganismos. Porém, o uso desses medicamentos foi inadequado, o que ocasionou a resistência de parte desses seres vivos e inviabilizou o uso de alguns fármacos na atualidade, por isso a importância do desenvolvimento de novas terapias farmacológicas contra esses organismos. A andiroba é uma árvore bastante presente na região amazônica e já era usada por nativos da daquela localidade para diversos fins terapêuticos. Alguns trabalhos buscaram averiguar parte dessas propriedades medicinais. Porém, esses estudos não haviam trabalhado com o óleo fixo da planta, além de poucos abordarem sobre o efeito antimicrobiano. Por causa disso, foi pensado no uso da nanotecnologia para desenvolver uma nanoemulsão com o óleo de andiroba. Desse modo, o objetivo do trabalho foi desenvolver e caracterizar uma formulação de nanoemulsão contendo o óleo fixo filtrado de andiroba por técnica de baixo cisalhamento, através da inversão de fases. A formulação preparada foi caracterizada analisando-se o diâmetro das partículas, o Índice de Polidispersão, o Potencial Zeta e o Potencial Hidrogeniônico. De fato, foi possível desenvolver uma nanoemulsão estável, além de ter sido caracterizado qual a concentração de óleo e a proporção de tensoativos adequadas para o uso. 2022-12-21T21:49:12Z 2022-12-21T21:49:12Z 2022-11-22 bachelorThesis PIRES, Pedro Vinícius Matias. Formulação de Nanoemulsão Contendo o Óleo de Andiroba. 2022. 50f. Trabalho de Conclusão de Curso (Graduação em Farmácia), Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2022. https://repositorio.ufrn.br/handle/123456789/50426 pt_BR application/pdf Universidade Federal do Rio Grande do Norte Brasil UFRN Farmácia. Departamento de Farmácia
institution Repositório Institucional
collection RI - UFRN
language pt_BR
topic Antimicrobiano
Nanotecnologia
Óleo de andiroba
Nanoemulsão
Inversão de fases
CNPQ::CIENCIAS DA SAUDE
spellingShingle Antimicrobiano
Nanotecnologia
Óleo de andiroba
Nanoemulsão
Inversão de fases
CNPQ::CIENCIAS DA SAUDE
Pires, Pedro Vinícius Matias
Formulação de nanoemulsão contendo o óleo de andiroba
description Antimicrobials were and continue to be very important for humanity, since they managed to reduce deaths caused by diseases caused by microorganisms. However, the use of these drugs was inadequate, which generated resistance on the part of these living beings and made the use of some drugs unfeasible at present, hence the importance of developing new drug therapies against these organisms. The andiroba is a tree that is very present in the Amazon region and was already used by the indigenous people of that town for various therapeutic purposes. Some studies sought to investigate part of these medicinal properties. However, these studies had not worked with the fixed oil of the plant, and few addressed the antimicrobial effect. Because of this, the use of nanotechnology was considered to develop a nanoemulsion with andiroba oil. Therefore, the objective of this work was to develop and characterize a nanoemulsion formulation containing fixed andiroba oil filtered by a low shear technique, through phase inversion. The prepared formulation was characterized by analyzing the particle diameter, the Polydispersion Index, the Zeta Potential and the Hydrogen Ionic Potential. In fact, it was possible to develop a stable nanoemulsion, in addition to characterizing the concentration of oil and the proportion of surfactants suitable for its use.
author2 Silva Júnior, Arnóbio Antônio da
author_facet Silva Júnior, Arnóbio Antônio da
Pires, Pedro Vinícius Matias
format bachelorThesis
author Pires, Pedro Vinícius Matias
author_sort Pires, Pedro Vinícius Matias
title Formulação de nanoemulsão contendo o óleo de andiroba
title_short Formulação de nanoemulsão contendo o óleo de andiroba
title_full Formulação de nanoemulsão contendo o óleo de andiroba
title_fullStr Formulação de nanoemulsão contendo o óleo de andiroba
title_full_unstemmed Formulação de nanoemulsão contendo o óleo de andiroba
title_sort formulação de nanoemulsão contendo o óleo de andiroba
publisher Universidade Federal do Rio Grande do Norte
publishDate 2022
url https://repositorio.ufrn.br/handle/123456789/50426
work_keys_str_mv AT pirespedroviniciusmatias formulacaodenanoemulsaocontendoooleodeandiroba
_version_ 1773960036923473920

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