Desenvolvimento e estudo de nanoemulsões para incorporação de triancinolona acetonida
Recurrent aphthous stomatitis (RAS) is the most common condition of the oral mucosa. Some local and systemic factors may be associated to the disease and there is evidence that an immunogenetic basis may be present. Disease control depends on its clinical presentation and includes immunosuppre...
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| Formato: | bachelorThesis |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/handle/123456789/50284 |
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| Resumo: | Recurrent aphthous stomatitis (RAS) is the most common condition of the oral mucosa.
Some local and systemic factors may be associated to the disease and there is
evidence that an immunogenetic basis may be present. Disease control depends on
its clinical presentation and includes immunosuppressive drugs, topical and systemic
corticosteroids, anesthetic and antimicrobial solutions. Triamcinolone acetonide (TA)
is an organic compound, defined as a synthetic corticosteroid used topically for the
treatment and relief of dermatopathies and oral inflammatory lesions, such as mouth
ulcers. As it is a low solubility compound in aqueous medium, it’s incorporation into
hydrophilic films is hampered, the nanoemulsion becomes a solution to develop a new
pharmaceutical form. Therefore, it was aimed to obtain a stable nanoemulsion with TA
incorporation. In this work, a prototype of TA was incorporated into nanoemulsion, the
aqueous phase (FA) being composed of glycerin, soybean oil, Tween 80® and Span
80® and the oil phase (FO) being composed of polaxamer 407 (P407) and water, by
phase inversion method. The characterization was carried out in terms of droplet size,
polydispersity index (PDI), hydrogenion potential (pH), zeta potential and standard
deviation, and these same parameters were used to evaluate the stability of the
system.The incorporations of 1%, 2.5% and 5% of triamcinolone in the nanoemulsions
were sustained droplet sizes < 200 nm and PDI < 0.3. However, due to the drug
sedimentation during the study, new possibilities for maintaining stability were tested,
with the incorporation of a cream gel being one of them. The cream gel consists of an
aqueous phase, composed of a gel former, such as carbomer or hydroxyethylcellulose,
and an oil phase, composed of waxes and light emollients. The gelling process
contributed greatly to increase the viscosity of the samples, may contribute to prevent
drug-leakage. The nanoemulsion systems incorporated with TA were successfully
obtained and characterized, showcasing significant and relevant results for the
development of this current formulation as an alternative treatment for aphthosis,
allowing, consequently, the continuation of the study, aiming to improve it, with the
development of new tests. |
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