Preliminary evidence of links between ayahuasca use and the corpus callosum

Background: Recent research suggests that ayahuasca and its alkaloid-containing ingredients may be helpful in the treatment and prevention of certain movement and neurodegenerative disorders. However, such research is still in its infancy and more studies in normative samples seem necessary to explo...

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Principais autores: Simonsson, Otto, Bouso, José Carlos, Kurth, Florian, Araujo, Draulio Barros de, Gaser, Christian, Riba, Jordi, Luders, Eileen
Formato: article
Idioma:English
Publicado em: Frontiers Media SA
Assuntos:
Hallucinogens
Psychedelics
Banisteriopsis
Ayahuasca
Alkaloids
Corpus callosum - Drug effects
Nerve degeneration - Prevention & control
Endereço do item:https://repositorio.ufrn.br/handle/123456789/50277
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spelling ri-123456789-502772022-12-19T19:09:03Z Preliminary evidence of links between ayahuasca use and the corpus callosum Simonsson, Otto Bouso, José Carlos Kurth, Florian Araujo, Draulio Barros de Gaser, Christian Riba, Jordi Luders, Eileen Hallucinogens Psychedelics Banisteriopsis Ayahuasca Alkaloids Corpus callosum - Drug effects Nerve degeneration - Prevention & control Background: Recent research suggests that ayahuasca and its alkaloid-containing ingredients may be helpful in the treatment and prevention of certain movement and neurodegenerative disorders. However, such research is still in its infancy and more studies in normative samples seem necessary to explore effects of ayahuasca on clinically relevant brain structures, such as the corpus callosum. Aims: The purpose of the present study was to investigate links between ayahuasca use and callosal structure in a normative sample. Methods: Using structural imaging data from 22 ayahuasca users and 22 matched controls we compared the thickness of the corpus callosum between both groups at 100 equidistant points across the entire midsagittal surface. In addition, we investigated point-wise correlations between callosal thickness and the number of past ayahuasca sessions. Results: The corpus callosum was significantly thicker within the isthmus in the ayahuasca group than in the control group. There was also a significant positive correlation between callosal thickness and the number of past ayahuasca sessions within the rostral body, albeit none of these effects survived corrections for multiple comparisons. No region was significantly thicker in the control than in the ayahuasca group, and no callosal region was negatively linked to ayahuasca use, even at uncorrected significance thresholds. Conclusion: This study provides preliminary evidence of links between ayahuasca use and the corpus callosum. However, future studies need to replicate these findings, preferably using larger sample sizes and ideally also utilizing longitudinal research designs, to draw any practical conclusion and offer implications for follow-up clinical research 2022-12-19T19:09:03Z 2022-12-19T19:09:03Z 2022-10 article SIMONSSON, Otto; BOUSO, José Carlos; KURTH, Florian; ARAUJO, Draulio B.; GASER, Christian; RIBA, Jordi; LUDERS, Eileen. Preliminary evidence of links between ayahuasca use and the corpus callosum. Frontiers In Psychiatry, [S. l.], v. 13, p. 1002455, out. 2022. Doi: http://dx.doi.org/10.3389/fpsyt.2022.1002455. Disponível em: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1002455/full. Acesso em: 14 dez. 2022 https://repositorio.ufrn.br/handle/123456789/50277 10.3389/fpsyt.2022.1002455 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Frontiers Media SA
institution Repositório Institucional
collection RI - UFRN
language English
topic Hallucinogens
Psychedelics
Banisteriopsis
Ayahuasca
Alkaloids
Corpus callosum - Drug effects
Nerve degeneration - Prevention & control
spellingShingle Hallucinogens
Psychedelics
Banisteriopsis
Ayahuasca
Alkaloids
Corpus callosum - Drug effects
Nerve degeneration - Prevention & control
Simonsson, Otto
Bouso, José Carlos
Kurth, Florian
Araujo, Draulio Barros de
Gaser, Christian
Riba, Jordi
Luders, Eileen
Preliminary evidence of links between ayahuasca use and the corpus callosum
description Background: Recent research suggests that ayahuasca and its alkaloid-containing ingredients may be helpful in the treatment and prevention of certain movement and neurodegenerative disorders. However, such research is still in its infancy and more studies in normative samples seem necessary to explore effects of ayahuasca on clinically relevant brain structures, such as the corpus callosum. Aims: The purpose of the present study was to investigate links between ayahuasca use and callosal structure in a normative sample. Methods: Using structural imaging data from 22 ayahuasca users and 22 matched controls we compared the thickness of the corpus callosum between both groups at 100 equidistant points across the entire midsagittal surface. In addition, we investigated point-wise correlations between callosal thickness and the number of past ayahuasca sessions. Results: The corpus callosum was significantly thicker within the isthmus in the ayahuasca group than in the control group. There was also a significant positive correlation between callosal thickness and the number of past ayahuasca sessions within the rostral body, albeit none of these effects survived corrections for multiple comparisons. No region was significantly thicker in the control than in the ayahuasca group, and no callosal region was negatively linked to ayahuasca use, even at uncorrected significance thresholds. Conclusion: This study provides preliminary evidence of links between ayahuasca use and the corpus callosum. However, future studies need to replicate these findings, preferably using larger sample sizes and ideally also utilizing longitudinal research designs, to draw any practical conclusion and offer implications for follow-up clinical research
format article
author Simonsson, Otto
Bouso, José Carlos
Kurth, Florian
Araujo, Draulio Barros de
Gaser, Christian
Riba, Jordi
Luders, Eileen
author_facet Simonsson, Otto
Bouso, José Carlos
Kurth, Florian
Araujo, Draulio Barros de
Gaser, Christian
Riba, Jordi
Luders, Eileen
author_sort Simonsson, Otto
title Preliminary evidence of links between ayahuasca use and the corpus callosum
title_short Preliminary evidence of links between ayahuasca use and the corpus callosum
title_full Preliminary evidence of links between ayahuasca use and the corpus callosum
title_fullStr Preliminary evidence of links between ayahuasca use and the corpus callosum
title_full_unstemmed Preliminary evidence of links between ayahuasca use and the corpus callosum
title_sort preliminary evidence of links between ayahuasca use and the corpus callosum
publisher Frontiers Media SA
publishDate 2022
url https://repositorio.ufrn.br/handle/123456789/50277
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