Problemas relacionados a medicamentos nas síndromes hipertensivas gestacionais.
Introduction: Hypertensive syndromes during pregnancy are frequent and antihypertensive therapy is impacted by physiological changes related to pregnancy, which increases the risk of drug-related problems (DRP). Objective: to characterize the main DRPs and their causes related to antihypertensive th...
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Problemas relacionados a medicamentos anti-hipertensivos gestação problemas relacionados a medicamentos; reações adversas inefetividade ineffectiveness antihypertensives drug-related problems; Adverse reactions Adverse reactions CNPQ::CIENCIAS DA SAUDE |
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Problemas relacionados a medicamentos anti-hipertensivos gestação problemas relacionados a medicamentos; reações adversas inefetividade ineffectiveness antihypertensives drug-related problems; Adverse reactions Adverse reactions CNPQ::CIENCIAS DA SAUDE Silva, Anny Laryssa Ferreira da Problemas relacionados a medicamentos nas síndromes hipertensivas gestacionais. |
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Introduction: Hypertensive syndromes during pregnancy are frequent and antihypertensive therapy is impacted by physiological changes related to pregnancy, which increases the risk of drug-related problems (DRP). Objective: to characterize the main DRPs and their causes related to antihypertensive therapy in hospitalized pregnant women. Methods: prospective cohort approved by the institutional Research Ethics Committee. All patients consented to participate. Data collection was carried out at the Januário Cicco Maternity School, in the city of Natal-RN, through daily interviews with 547 patients from the high-risk ward, during the months of August 2019 to August 2021. The descriptive analysis with the Stata software version 13. Results: during the study, 33.6% (184) patients had arterial hypertension, 34.2% (187) had gestational hypertension and 12.8% (70) had preeclampsia. The mean treatment time for patients was 5.6 ± 4.2 days, with approximately 7.4 ± 2.9 medications being used per pregnant woman. The most prescribed antihypertensives were hydralazine 20 mg/mL AMP with 38.3% (374), followed by methyldopa 250 mg WITH 28.9% (282), methyldopa 500 mg WITH 16.3% (159) and nifedipine 20 mg COM 12.2% (119). In the MRP profile, the non-ideal drug treatment of nifedipine 20mg presented 63.4%, followed by methyldopa 500mg, 58.9% and methyldopa 250mg, 57.7%. Hydralazine 20mg/mL presented a distinct profile, with a predominance of adverse events among its DRPs, with 88.9%. Conclusion: Of the antihypertensive drugs analyzed, methyldopa 250mg and nifedipine 20mg stood out for their therapeutic ineffectiveness. Regarding the occurrence of adverse reactions, all analyzed drugs had at least one event. These facts occurred mainly during the first two days of hospitalization. |
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Martins, Rand Rand Randall |
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Martins, Rand Rand Randall Silva, Anny Laryssa Ferreira da |
| format |
bachelorThesis |
| author |
Silva, Anny Laryssa Ferreira da |
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Silva, Anny Laryssa Ferreira da |
| title |
Problemas relacionados a medicamentos nas síndromes hipertensivas gestacionais. |
| title_short |
Problemas relacionados a medicamentos nas síndromes hipertensivas gestacionais. |
| title_full |
Problemas relacionados a medicamentos nas síndromes hipertensivas gestacionais. |
| title_fullStr |
Problemas relacionados a medicamentos nas síndromes hipertensivas gestacionais. |
| title_full_unstemmed |
Problemas relacionados a medicamentos nas síndromes hipertensivas gestacionais. |
| title_sort |
problemas relacionados a medicamentos nas síndromes hipertensivas gestacionais. |
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Universidade Federal do Rio Grande do Norte |
| publishDate |
2022 |
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https://repositorio.ufrn.br/handle/123456789/50041 |
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AT silvaannylaryssaferreirada problemasrelacionadosamedicamentosnassindromeshipertensivasgestacionais AT silvaannylaryssaferreirada drugrelatedproblemsingestationalhypertensivesyndromes |
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ri-123456789-500412022-12-08T18:44:01Z Problemas relacionados a medicamentos nas síndromes hipertensivas gestacionais. Drug-related problems in gestational hypertensive syndromes. Silva, Anny Laryssa Ferreira da Martins, Rand Rand Randall Bezerra, Priscilla Karilline Do Vale Bezerra Diniz, Rodrigo Rodrigo dos Santos Bitencourt, Mariana Mariana Angélica Oliveira Problemas relacionados a medicamentos anti-hipertensivos gestação problemas relacionados a medicamentos; reações adversas inefetividade ineffectiveness antihypertensives drug-related problems; Adverse reactions Adverse reactions CNPQ::CIENCIAS DA SAUDE Introduction: Hypertensive syndromes during pregnancy are frequent and antihypertensive therapy is impacted by physiological changes related to pregnancy, which increases the risk of drug-related problems (DRP). Objective: to characterize the main DRPs and their causes related to antihypertensive therapy in hospitalized pregnant women. Methods: prospective cohort approved by the institutional Research Ethics Committee. All patients consented to participate. Data collection was carried out at the Januário Cicco Maternity School, in the city of Natal-RN, through daily interviews with 547 patients from the high-risk ward, during the months of August 2019 to August 2021. The descriptive analysis with the Stata software version 13. Results: during the study, 33.6% (184) patients had arterial hypertension, 34.2% (187) had gestational hypertension and 12.8% (70) had preeclampsia. The mean treatment time for patients was 5.6 ± 4.2 days, with approximately 7.4 ± 2.9 medications being used per pregnant woman. The most prescribed antihypertensives were hydralazine 20 mg/mL AMP with 38.3% (374), followed by methyldopa 250 mg WITH 28.9% (282), methyldopa 500 mg WITH 16.3% (159) and nifedipine 20 mg COM 12.2% (119). In the MRP profile, the non-ideal drug treatment of nifedipine 20mg presented 63.4%, followed by methyldopa 500mg, 58.9% and methyldopa 250mg, 57.7%. Hydralazine 20mg/mL presented a distinct profile, with a predominance of adverse events among its DRPs, with 88.9%. Conclusion: Of the antihypertensive drugs analyzed, methyldopa 250mg and nifedipine 20mg stood out for their therapeutic ineffectiveness. Regarding the occurrence of adverse reactions, all analyzed drugs had at least one event. These facts occurred mainly during the first two days of hospitalization. Introdução: as síndromes hipertensivas na gestação são frequentes e terapêutica anti-hipertensiva é impactada por alterações fisiológicas relacionadas a gravidez o que eleva o risco de problemas relacionados a medicamentos (PRM). Objetivo: caracterizar os principais PRMs e suas causas relacionadas a terapia anti-hipertensiva de gestantes hospitalizadas. Métodos: coorte prospectiva aprovada por Comitê de Ética e Pesquisa institucional. Todas as pacientes consentiram em participar. A coleta de dados foi realizada na Maternidade Escola Januário Cicco, no município de Natal-RN, por meio de entrevistas diárias com 547 pacientes da ala de alto risco, durante os meses de agosto de 2019 a agosto de 2021. A análise descritiva com o programa Stata versão 13. Resultados: durante o estudo, 33,6% (184) pacientes apresentavam hipertensão arterial, 34,2% (187) hipertensão gestacional e 12,8% (70) quadro de pré-eclampsia. A média de tempo de tratamento das pacientes foi de 5,6 ± 4,2 dias, sendo utilizados cerca de 7,4 ± 2,9 medicamentos por gestante. Os anti-hipertensivos mais prescritos foram hidralazina 20 mg/mL AMP com 38,3% (374), seguido por metildopa 250 mg COM 28,9% (282), metildopa 500 mg COM 16,3% (159) e nifedipino 20 mg COM 12,2% (119). No perfil de PRM, o tratamento medicamentoso não ideal do nifedipino 20mg apresentou 63,4%, seguido de metildopa 500mg 58,9% e metildopa 250mg, 57,7%. A hidralazina 20mg/mL apresentou um perfil distinto, tendo um predomínio de eventos adversos entre seus PRMs, com 88,9%. Conclusão: Dos anti-hipertensivos analisados, metildopa 250mg e nifedipino 20mg se destacaram pela inefetividade terapêutica. Sobre a ocorrência de reações adversas, todos os medicamentos analisados obtiveram pelo menos um evento. Esses fatos ocorreram principalmente durante os dois primeiros dias de internação. 2022-12-08T18:44:00Z 2022-12-08T18:44:00Z 2022-11-25 bachelorThesis SILVA, Anny Laryssa Ferreira da. Problemas relacionados a medicamentos nas síndromes hipertensivas gestacionais.2022. 29f. Trabalho de Conclusão de Curso (Graduação em Farmácia), Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2022. https://repositorio.ufrn.br/handle/123456789/50041 pt_BR Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Universidade Federal do Rio Grande do Norte Brasil UFRN Farmácia Farmácia |